Relative hydrophobicity of di- to hexapeptides as measured by aqueous two-phase partitioning

Journal of Peptide Research

Volumn 61, Issue 3, 2003, Pages 129-139

  Gulyaeva, N ^a   Zaslavsky, A ^a   Chait, A ^a   Zaslavsky, Boris Y ^a  

^a Analiza Inc   (United States)

Author keywords

Aqueous two phase partitioning; Hydrophobicity; Lipophilicity; Partition coefficient; Peptides; QSAR

Indexed keywords

AMINO ACID; DIPEPTIDE; HEXAPEPTIDE; OLIGOPEPTIDE; POLYMER;

AQUEOUS SOLUTION; ARTICLE; HYDROPHOBICITY; LIPOPHILICITY; PARTITION COEFFICIENT; PEPTIDE ANALYSIS; PH; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

CHEMISTRY; DEXTRANS; HYDROGEN-ION CONCENTRATION; LIPIDS; PEPTIDES; SODIUM CHLORIDE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037372952     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3011.2003.00040.x     Document Type: Article

References (15)

1. Hansch, C. & Leo, A. (1995) Exploring QSAR: Fundamentals and Applications in Chemistry and Biology. American Chemical Society, Washington, DC.
2. Caron, G., Reymond, F., Carrupt, P.-A., Girault, H.H. & Testa, B. (1999) Combined molecular lipophilicity descriptors and their role in understanding intramolecular effects. Pharmac. Sci. Technol. Today 2, 327-335 (1999).
3. Walter, W.P., Ajay & Murcko, M.A. (1999) Recognizing molecules with drug-like properties. Curr. Opin. Chem. Biol. 3, 384-387.
4. Gulyaeva, N., Zaslavsky, A., Chait, A. & Zaslavsky, B. (2002) Relative hydrophobicity of amino acid residues in homo-oligopeptides as measured by aqueous two-phase partitioning. J. Peptide Res. 59, 277-282.
5. van de Waterbeemd, H., Karajiannis, H. & El Tayar, N. (1994) Lipophilicity of amino acids. Amino Acids 7, 129-145.
6. Karplus, P. (1997) Hydrophobicity regained. Protein Sci. 6, 1302-1307.
7. Zaslavsky, B. (1995) Aqueous Two-Phase Partitioning: Physical Chemistry and Bioanalytical Applications. Marcel Dekker, New York.
8. Zaslavsky, B., Borovskaya, A., Gulaeva, N. & Miheeva, L. (1991) Partitioning in aqueous two-phase systems as a method of estimation of the relative hydrophobicity of solutes. J. Chem. Soc., Faraday Trans. 87, 137-140.
9. Gulyaeva, N., Zaslavsky, A., Lechner, P., Chait, A. & Zaslavsky, B. (2000) Relative hydrophobicity of organic compounds measured by partitioning in aqueous two-phase systems. J. Chromatogr B. 743, 187-194.
10. Gulyaeva, N., Zaslavsky, A., Chait, A. & Zaslavsky, B. (2001) Measurement of the relative hydrophobicity of organic compounds without organic solvent effects of salt composition and ph on organic acids and non-ionic compounds. J. Pharm Sci. 90, 1366-1374.
11. Zaslavsky, A., Gulyaeva, N. & Zaslavsky, B. (2000) Peptides partitioning in an aqueous dextran-polyethylene glycol two-phase system. J. Chromatogr. B. 743, 271-279.
12. Akamatsu, M. & Fujita, T. (1992) Quantitative analysis of hydrophobicity of di- to pentapeptides having un-ionizable side chains with substituent and structural parameters. J. Pharm. Sci. 81, 164-174.
13. Akamatsu, M., Yoshida, Y., Nakamura, H., Asao, M., Iwamura, H. & Fujita, T. (1989) Hydrophobicity of di- and tripeptides having unionizable side chains and correlation with substituent and structural parameters. Quant. Struct.-Act. Relat. 8, 195-203.
14. Asao, M., Iwamura, H., Akamatsu, M. & Fujita, T. (1987) Quantitative structure-activity relationships of the bitter thresholds of amino acids, peptides, and their derivatives. J. Med. Chem. 30, 1873-1879.
15. Yunger, L.M. & Cramer, R.D. (1981) Measurement and correlation of partition coefficients of polar amino acids. Mol. Pharmacol. 20, 602-608.