Pleconaril, a novel antipicornaviral agent

Pharmacotherapy

Volumn 23, Issue 3, 2003, Pages 339-348

  Florea, Naomi R ^a   Maglio, Dana ^a   Nicolau, David P ^a  

^a HARTFORD HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLACEBO; PLECONARIL;

ABDOMINAL PAIN; ADULT; AREA UNDER THE CURVE; CLINICAL TRIAL; COMPARTMENT MODEL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG INDICATION; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG SAFETY; ENTEROVIRUS; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MENINGITIS; NAUSEA; PICORNAVIRUS; PICORNAVIRUS INFECTION; RESPIRATORY TRACT INFECTION; REVIEW; RHINOVIRUS;

ADOLESCENT; ADULT; AGED; ANTIVIRAL AGENTS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; HALF-LIFE; HUMANS; MIDDLE AGED; OXADIAZOLES; PICORNAVIRIDAE INFECTIONS; RANDOMIZED CONTROLLED TRIALS;

EID: 0037371294     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1592/phco.23.3.339.32099     Document Type: Review

References (46)

1. National Institute of Allergy and Infectious Diseases. Common cold fact sheet. Bethesda, MD: National Institute of Health, 1998.
2. Halonen P, Rocha E, Hierholzer J, et al. Detection of enteroviruses and rhinoviruses in clinical specimens by PCR and liquid-phase hybridization. J Clin Microbiol 1995;33(3):648-53.
3. Chidekel AS, Rosen CL, Buzzy AR. Rhinovirus infection associated with,serious lower respiratory illness in patients with bronchopulmonary dysplasia. Pediatr Infect Dis J 1997;16(1):43-7.
4. Rotbart HA. Meningitis and encephalitis. In: Rotbart HA, ed. Human enterovirus infections. Washington, DC: American Society for Microbiology Press, 1995:271-89.
5. Whitley RJ, Cobbs CG, Alford CA, et al. Diseases that mimic herpes simplex encephalitis. JAMA 1989;262:234-9.
6. Strikas RA, Anderson LJ, Parker RA. Temporal and geographic patterns of isolates of nonpolio enterovirus in the United States, 1970-1983. J Infect Dis 1986;153:346-51.
7. Treanor J. Respiratory infections. In: Richman DD, Whitley RJ, Hayden FG, eds. Clinical virology. New York: Churchill Livingstone, 1997:5-33.
8. Gwaltney JM. Rhinovirus. In: Mandell GL, Bennet JE, Dolin R, eds. Principles and practice of infectious diseases, 5th ed. New York: Churchill Livingstone, 2000:1940-8.
9. Monto AS, Cavallaro JJ. The Tecumseh study of respiratory illness. II. Patterns of occurrence of infection with respiratory pathogens, 1965-1969. Am J Epidemiol 1971;94:280-9.
10. van Kempen M, Bachert C, Van Cauwenberge P. An update on the pathophysiology of rhinovirus upper respiratory tract infections. Rhinology 1999;37:97-103.
11. Winther B, Gwaltney JM Jr, Mygind N, et al. Sites of recovery after point inoculation of the upper airway. JAMA 1986;256:1763-7.
12. Turner RB. The treatment of rhinovirus infections: progress and potential. Antiviral Res 2001;49:1-14.
13. Arola M, Ruuskanen O, Ziegler T, et al. Clinical role of respiratory virus infection in acute otitis media. Pediatrics 1990;86:848-55.
14. Nicholson KG, Kent J, Hammersley V, et al. Risk factors for lower respiratory complications of rhinovirus infections in elderly people living in the community: prospective cohort Study. BMJ 1996;313:1119-23.
15. Wald TG, Shult P, Krause P, et al. A rhinovirus outbreak among residents of a long-term care facility. Ann Intern Med 1995;123:588-93.
16. Schmidt HJ, Fink RJ. Rhinovirus as a lower respiratory pathogen in infants. Pediatr Infect Dis J 1991;10:700-2.
17. Chidekel AS, Bazzy AR, Rosen CL. Rhinovirus infection associated with severe lower respiratory tract illness and worsening lung disease in infants with bronchopulmonary dysplasia. Pediatr Pulmonol 1994;18:261-3.
18. Nicholson KG, Kent J, Ireland DC. Respiratory viruses and exacerbations of asthma in adults. BMJ 1993;307:982-6.
19. Johnston SL, Pattermore PK, Sanderson G, et al. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ 1995;310:1225-9.
20. Johnston SL, Pattermore PK, Sanderson G, et al. The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis. Am J Respir Crit Care Med 1996;154:654-60.
21. Minor TE, Baker JW, Dick E, et al. Greater frequency of viral respiratory infection in asthmatic children as compared with their nonasthmatic siblings. Pediatrics 1974;85:472-7.
22. Stenhouse AC. Rhinovirus infection in acute exacerbations of chronic bronchitis: a controlled prospective study. Br Med J 1967;3:461-3.
23. Cherry JD. Enteroviruses: coxsackieviruses, enteroviruses and polioviruses. In: Feigin RD, Cherry JD, eds. Textbook of pediatric infectious diseases, 4th ed. Philadelphia: WB Saunders, 1998:1787-1839.
24. Wu JM, Wang JN, Tsai YC, et al. Cardiopulmonary manifestations of fulminant enterovirus 71 infection. Pediatrics 2002;109:1-5.
25. Lin TY, Chang LY, Hsia SH, et al. The 1998 enterovirus 71 outbreak in Taiwan: pathogenesis and management. Clin Infect Dis 2000;34(suppl):S52-7.
26. Greve JM, Davis G, Meyer AM, et al. The major rhinovirus receptor is ICAM-1. Cell 1989;56:839-47.
27. Staunton DE, Merluzzi VJ, Rothlein R, et al. A cell adhesion molecule, 1CAM-1 is the major surface receptor for rhinoviruses. Cell 1989;56:849-53.
28. Hofer F, Gruenberger M, Kowlaski H, et al. Members of the low density lipoprotein receptor family mediate cell entry of a minor-group common cold virus. Proc Natl Acad Sci USA 1994;91:1839-42.
29. Pevear DC, Seipel ME, Pallansch M, et al. In vitro activity of VP 63843 against field isolates of non-polio enteroviruses [abstr]. In: Program and abstracts of the 36th interscience conference on antimicrobial agents and chemotherapy. Washington, DC: American Society for Microbiology, 1996:181.
30. Rhodes G, Liu S. Effects of age and gender on pleconaril pharmacokinetics [abstr]. In: Program and abstracts of the 41st interscience conference on antimicrobial agents and chemotherapy. Washington, DC: American Society for Microbiology, 2001:12.
31. Rhodes G, Liu S. Multiple dose pharmacokinetics of pleconaril tablets in healthy adults [abstr]. In: Program and abstracts of the 41st interscience conference on antimicrobial agents and chemotherapy. Washington, DC: American Society for Microbiology, 2001:12.
32. Abdel-Rahman SM, Kearns GL. Single dose pharmacokinetics of pleconaril (VP 63843) oral suspension and effect of food. Antimicrob Agents Chemother 1998;42:2706-9.
33. 14C]-pleconaril in healthy adult males [abstr]. In: Program and abstracts of the 41st interscience conference on antimicrobial agents and chemotherapy. Washington, DC: American Society for Microbiology, 2001:12.
34. Kearns GL, Bradley JS, Jacobs RF, et al. Single dose pharmacokinetics of pleconaril in neonates. Pediatr Infect Dis J 2000;19:833-9.
35. Kearns GL, Abdel-Rahman SM, James LP, et al. Single dose pharmacokinetics of pleconaril (VP63843) oral solution in children and adolescents. Antimicrob Agents Chemother 1999;42(10):634-8.
36. Viropharma, Inc. VP 63843 clinical investigator's brochure. Exton, PA; 2001.
37. Rhodes G, Haughey D, Liu S. Effect of repeat doses of pleconaril on pharmacokinetics of theophylline in healthy adults [abstr]. In: Program and abstracts of the 41st interscience conference on antimicrobial agents and chemotherapy. Washington, DC: American Society for Microbiology, 2001:13.
38. Rhodes G, Harling S, Hincks J. Effect of pleconaril on hepatic levels of CYP450 enzymes in rat and dog liver microsomes following in vivo dosing [abstr]. In: Program and abstracts of the 41st interscience conference on antimicrobial agents and chemotherapy. Washington, DC: American Society for Microbiology, 2001:13.
39. Schiff GM, Sherwood JR. Clinical activity of pleconaril in an experimentally induced coxsackievirus A21 respiratory infection. J Infect Dis 2000;181:20-6.
40. Hayden FG, Coats T, Kim K, et al. Oral pleconaril treatment of picornavirus-associated viral respiratory illness in adults: efficacy and tolerability in phase II clinical trials. Antiviral Ther 2002;7:53-65.
41. Hayden FG, Kim K, Hudson S. Pleconaril treatment reduces duration and severity of viral respiratory infection (common cold) due to picornaviruses [abstr]. In: Program and abstracts of the 41st interscience conference on antimicrobial agents and chemotherapy. Washington, DC: American Society for Microbiology, 2001:288.
42. Shafran SD, Halota W, Gilbert D, et al. Pleconaril is effective for enteroviral meningitis in adolescents and adults: a randomized placebo-controlled multicenter trial [abstr]. In: Program and abstracts of the 39th interscience conference on antimicrobial agents and chemotherapy. Washington, DC: American Society for Microbiology, 1999:436.
43. Sawyer MH, Saez-Llorenz X, Aviles CL, et al. Oral pleconaril reduces the duration and severity of enteroviral meningitis in children. Presented at the annual meeting of the Pediatric Academic Society, San Francisco, CA, May 1-4, 1999.
44. Rotbart HA, Webster AD. Treatment of potentially life-threatening enterovirus infections with pleconaril. Clin Infect Dis 2001;32:228-35.
45. Berger MM, Kopp N, Vital C, et al. Detection and cellular localization of enterovirus RNA sequences in spinal cord of patients with ALS. Neurology 2000;54:20-5.
46. Food and Drug Administration. Antiviral drugs advisory committee report. Available from www.fda.gov/ohrms/dockets/ac/02/transcripts/3847tl.pdf. Accessed November 10, 2002.