A mathematical model for the investigation of the Th1 immune response to Chlamydia trachomatis

Mathematical Biosciences

Volumn 182, Issue 1, 2003, Pages 27-44

  Wilson, D P ^a   Timms, P ^a   McElwain, D L S ^a  

^a QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

Chlamydia; Developmental cycle; Immune; Mathematical model; Th1

Indexed keywords

BACTERIA; CELLS; DISEASES; HEALTH RISKS; MATHEMATICAL MODELS;

SEXUALLY TRANSMITTED DISEASES;

ANTIGEN-ANTIBODY REACTIONS;

BACTERIAL DISEASE;

CELLULAR IMMUNITY; CHLAMYDIA TRACHOMATIS; CHLAMYDIASIS; DISEASE CONTROL; DISEASE COURSE; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; MATHEMATICAL MODEL; NONHUMAN; PATHOGENESIS; PNEUMONIA; PUBLIC HEALTH; REVIEW; SEXUALLY TRANSMITTED DISEASE; TH1 CELL; TRACHOMA;

ANIMALIA; BACTERIA (MICROORGANISMS); CHLAMYDIA; CHLAMYDIA TRACHOMATIS;

EID: 0037367914     PISSN: 00255564     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0025-5564(02)00180-3     Document Type: Article

References (23)

1. K.D.E. Everett, R.M. Bush, A.A. Anderson, Emended description of the order Chlamydiales, proposal of Parachlamydiaceae fam. Nov. and Simkaniaceae fam. Nov., each containing one monotypic genus, revised taxonomy of the family Chlamydiaceae, including a new genus and five new species, and standards for the identification of organisms, Int. J. Syst. Bacteriol. 49 (1999) 415.
2. K.W. Beagley, P. Timms, Chlamydia trachomatis infection: incidence, health costs and prospects for vaccine development, J. Reproduct. Immunol. 48 (2000) 47.
3. J.W. Moulder, Interaction of chlamydiae and host cells in vitro, Microbiol. Rev. 55 (1991) 143.
4. J. Schachter, Opportunistic Intracellular Bacteria and Immunity, Plenum, 1999.
5. X. Yang, R.C. Brunham, T lymphocyte immunity in host defence against Chlamydia trachomatis and its implication for vaccine development, Can. J. Infect. Dis. 9 (1998) 99.
6. J. Debattista, Chlamydia Literature Review, QUT Literature Review, 2001.
7. R. Malinerni, The role of cytokines in chlamydial infections, Curr. Opin. Infect. Dis. 9 (1996) 150.
8. M.A. Tanner, J.K. Harris, N.R. Pace, T.P. Hatch, G. McCarty, T. Hackstadt, J. Schachter, M.E. Ward, R.C. Brunham, R.G. Rank, P.J. Hitchcock, Chlamydia: Intracellular Biology, Pathogenesis and Immunity, American Society for Microbiology, Washington, DC, 1999.
9. M.J. Holland, R.L. Baliey, L.J. Hayes, H.C. Whittle, D.C.W. Mabey, Conjunctival scarring in trachoma is associated with depressed cell-mediated immune responses to chlamydial antigens, Infect. Dis. 168 (1993) 1528.
10. T.K. Cain, R.G. Rank, Local Th1-like responses are induced by intravaginal infection of mice with the mouse pneumonitis biovar of Chlamydia trachomatis, Infect. Immun. 63 (1995) 1784.
11. K.A. Kelly, E.A. Robinson, R.G. Rank, Initial route of antigen administration alters the T-Cell cytokine profile produced in response to the mouse pneumonitis biovar of Chlamydia trachomatis following genital infection, Infect. Immun. 64 (1996) 4976.
12. W.C. Van Voorhis, L.K. Barrett, Y.T. Cosgrove-Sweeney, C.-C. Kuo, D.L. Patton, Analysis of lymphocyte phenotype and cytokine activity in the inflammatory infiltrates of the upper genital tract of female macaques infected with Chlamydia trachomatis, Infect. Dis. 174 (1996) 647.
13. S.M. Anderton, R. van der Zee, B. Prakken, A. Noordzij, W. van Eden, Activation of T Cells recognizing self 60-kD heat shock protein can protect against experimental arthritis, Exp. Med. 181 (1995) 943.
14. J.U. Igietseme, P.B. Wyrick, D. Goyeau, R.G. Rank, An in vitro model for immune control of chlamydial growth in polarized epithelial cells, Infect. Immun. 62 (1994) 3528.
15. D.M. Magee, D.M. Williams, J.G. Smith, C.A. Bleicker, B.G. Grubbs, J. Schacter, R.G. Rank, Role of CD8 T Cells in primary Chlamydia infection, Infect. Immun. 63 (1995) 516.
16. K.H. Ramsey, L.S.F. Soderberg, R.G. Rank, Resolution of chlamydial genital infection in B-cell-deficient mice and immunity to reinfection, Infect. Immun. 56 (1988) 1320.
17. S. Mathews, C. George, C. Flegg, D. Stenzel, P. Timms, Differential expression of ompA, ompB, pyk, nlpD and Cpn 0585 genes between normal and interferon-gamma treated cultures of Chlamydia pneumoniae, Microbial Pathogen. 30 (2001) 337.
18. W.L. Beatty, R.P. Morrison, G.I. Byrne, Persistent chlamydiae: from cell-culture to a paradigm for chlamydial pathogenesis, Microbiol. Rev. 58 (1994) 686.
19. A. Harper, C. Pogson, M. Jones, J. Pearce, Chlamydial development is adversely affected by minor changes in amino acid supply, blood plasma amino acid levels and glucose deprivation, Infect. Immun. 68 (2000) 1457.
20. W.L. Beatty, T.A. Belanger, A.A. Desai, R.P. Morrison, G.I. Byrne, Tryptophan depletion as a mechanism of gamma interferon-mediated chlamydial persistence, Infect. Immun. 62 (1994) 3705.
21. W.L. Beatty, G.I. Byrne, R.P. Morrison, Morphological and antigenic characterisation of interferon mediated persistent Chlamydia trachomatis infection in vitro, Proc. Nat. Acad. Sci. USA. 90 (1993) 3998.
22. 0 in models for infectious diseases in heterogeneous populations, J. Math. Biol. 28 (1990) 365.
23. M.A. Nowak, R.M. May, Virus Dynamics: Mathematical Principles of Immunology and Virology, Oxford University, 2000.