Analysis of lymphocyte phenotype and cytokine activity in the inflammatory infiltrates of the upper genital tract of female macaques infected with Chlamydia trachomatis

Journal of Infectious Diseases

Volumn 174, Issue 3, 1996, Pages 647-650

  Van Voorhis, Wesley C ^a   Barrett, Lynn K ^b   Cosgrove Sweeney, Yvonne T ^b   Kuo, Cho Chou ^b   Patton, Dorothy L ^b  

^a Division of Infectious Diseases   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 6; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHLAMYDIA TRACHOMATIS; CONTROLLED STUDY; GENITAL TRACT INFECTION; HISTOPATHOLOGY; IMMUNE RESPONSE; LYMPHOCYTIC INFILTRATION; MACACA; NONHUMAN; PHENOTYPE; PRIMATE; PRIORITY JOURNAL;

EID: 0029781081     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/174.3.647     Document Type: Article

References (15)

1. Palton DL, Kuo CC. Histopathology of Chlamydia trachomatis salpingitis after primary and repeated reinfections in the monkey subcutaneous pocket model. J Reprod Fertil 1989;85:647-56.
2. Van Voorhis WC, Barrett LK, Koelle DM, Nasio JM, Plummer FA, Lukehart SA. Primary and secondary syphilis lesions contain mRNA for Th1 cytokines. J Infect Dis 1996;173:491-5.
3. Van Voorhis WC, Barrett LK, Nasio JM, Plummer FA, Lukehart SA. The lesions of primary and secondary syphilis contain activated cytolytic T cells. Infect Immun 1996;64:1048-50.
4. Starnbach MM, Bevan MJ, Lampe MF. Protective cytotoxic T lymphocytes are induced during murine infection with Chlamydia trachomatis. J Immunol 1994;153:5183-9.
5. Magee DM, Williams DM, Smith JG, et al. Role of CD8 T cells in primary Chlamydia infection. Infect Immun 1995;63:516-21.
6. + T cells play a significant role in adoptive immunity to Chlamydia trachomatis infection of the mouse genital tract. Infect Immun 1995;63:3302-8.
7. Cain TK, Rank RG. Local Th1-like responses are induced by intravaginal infection of mice with the mouse pneumonitis biovar of Chlamydia trachomatis. Infect Immun 1995;63:1784-9.
8. Simon AK, Seipelt E, Wu P, Wenzel B, Braun J, Sieper J. Analysis of cytokine profiles in synovial T cell clones from chlamydial reactive arthritis patients: predominance of the Th1 subset. Clin Exp Immunol 1993;94:122-6.
9. Schlaak JF, Nieder P, Meyer zum Buschenfelde KH, Fleisher B. Human T helper cells reactive with somatic bacterial antigens belong to the Th1 subset. Med Microbiol Immunol (Berl) 1994;183:169-75
10. Arno JN, Ricker VA, Batteiger BE, Katz BP, Caine VA, Jones RB. Interferon-γ in endocervical secretions of women infected with Chlamydia trachomatis. J Infect Dis 1990;162:1385-9.
11. Rank RG, Ramsey KH, Pack EA, Williams DM. Effect of gamma interferon on resolution of murine chlamydial genital infection. Infect Immun 1992;60:4427-9.
12. Beatty WL, Byrne GI, Morrison RP. Morphologic and antigenic characterization of interferon-γ-mediated persistent Chlamydia trachomatis infection in vitro. Proc Natl Acad Sci USA 1993;90:3998-4002.
13. Kovacs EJ. Fibrogenic cytokines: the role of immune mediators in the development of scar tissue. Immunol Today 1991;12:17-23.
14. Holaday BJ, Pompeu MML, Jeronimo S, et al. Potential role for interleukin-10 in the immunosuppression associated with kala-azar. J Clin Invest 1993;92:2626-32.
15. Malefyt RDW, Abrams J, Bennett B, Figdor CG, deVries JE. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991;174:1209-20.