Prevalence and clinical significance of circulating cryoglobulins in HIV-positive patients with and without co-infection with hepatitis C virus

Journal of Medical Virology

Volumn 69, Issue 3, 2003, Pages 339-343

  Fabris, Paolo ^a   Tositti, Giulia ^a   Giordani, Maria Teresa ^a   Romanò, Luisa ^b   Betterle, Corrado ^c   Pignattari, Elena ^a   Tagliaferri, Cinzia ^a   Muratori, Paolo ^d   Manfrin, Vinicio ^a   De Lalla, Fausto ^a  

^a SAN BORTOLO HOSPITAL   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

^d UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

AIDS; Cryoglobulins; HCV; HCV RNA; HIV; HIV viral load

Indexed keywords

AUTOANTIBODY; CRYOGLOBULIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ANTIBODY TITER; ARTICLE; CRYOGLOBULINEMIA; FEMALE; HEPATITIS C; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; LIVER CIRRHOSIS; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PREVALENCE; VIRUS DETECTION; VIRUS INFECTION; VIRUS LOAD;

ADULT; CRYOGLOBULINEMIA; CRYOGLOBULINS; FEMALE; HEPACIVIRUS; HEPATITIS C; HIV INFECTIONS; HIV-1; HUMANS; MALE; MIDDLE AGED; PREVALENCE; RNA, VIRAL; VIRAL LOAD;

HEPATITIS C VIRUS; HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0037358446     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/jmv.10294     Document Type: Article

References (24)

1. Adinolfi LE, Utili R, Attanasio V, Zampino P, Ragone E, Tripodi MF, Ruggero G. 1996. Epidemiology, clinical spectrum and prognostic value of mixed cryoglobulinemia in hepatitis C virus patients: a prospective study. Ital J Gastroenterol 28:1-9.
2. Agnello V. 1997. The etiology and pathophysiology of mixed cryoglobulinemia secondary to hepatitis C virus infection. Springer Semin Immunopathol 19:111-129.
3. Brouet JC, Clauvel JP, Danon F, Klein M, Seligman M. 1974. Biologic and clinical significance of cryoglobulins. A report of 86 cases. Am J Med 57:775-788.
4. Cacoub P, Lunel-Fabiani F, Musset L, Perin M, Frangeul L, Leger JM, Huraux JM, Plette JC, Godeau P. 1994. Mixed cryoglobulinemia and hepatitis C virus. Am J Med 96:124-132.
5. Casato M, Lagana B, Antonelli G, Dianzani F, Bonomi L. 1991. Long term results of therapy with interferon-alpha for type II essential mixed cryoglobulinemia. Blood 78:3142-3147.
6. Cicardi M, Cesana B, Del Ninno E, Pappalardo E, Silini E, Agostoni A, Colombo M. 2000. Prevalence and risk factors for the presence of serum cryoglobulins in patients with chronic hepatitis C. J Viral Hepatol 7:138-143.
7. Cohen P, Roulot D, Ferrière F, Nguyen QT, Lortholary O, Jarrousse B, Dény P, Coste T, Robineau M, Guillevin L. 1997. Prevalence of cryoglobulins and hepatitis C virus infection in HIV-infected patients. Clin Exp Rheumatol 15:523-527.
8. Dimitrakopoulos AN, Kordossis T, Hatzakis A, Moutsopoulos HM. 1999. Mixed cryoglobulinemia in HIV-1 infection: the role of HIV. Ann Intern Med 130:226-230.
9. Ferri C, Manzo E, Longobardo G, Greco F, Pasero G, Gentilini P, Bombardieri S, Zignego AL. 1993. Interferon-alpha in mixed cryoglobulinemia patients: a randomised, crossover-controlled trial. Blood 81:1132-1136.
10. Franchini M, Rossetti G, Tagliaferri A, Capra F, de Maria L, Pattacini C, Lippi G, Lo Cascio G, de Gironcoli M, Gandini G. 2001. The natural history of chronic hepatitis C in a cohort of HIV-negative Italian patients with hereditary bleeding disorders. Blood 98:1836-1841.
11. Galli M, Invernizzi F, Chemotti M, Monti G, Gasparro MG, Caredo Negri C, Moroni M. 1986. Cryoglobulins and infectious diseases. Ric Clin Lab 16:301-313.
12. Galli M. 1991. Cryoglobulinemia and serological markers of hepatitis viruses. Lancet 338:758-759.
13. Imberti L, Cariani E, Bettinardi A, Zonaro A, Albertini A, Primi D. 1991. An immunoassay for specific amplified HCV sequences. J Virol Methods 34:233-343.
14. Lunel F, Musset L, Cacoub P, Frangeul L, Cresta P, Perrin M, Grippon P, Hoang C, Piette JC, Huraux JM, Opolon P. 1994. Cryoglobulinemia in chronic liver diseases: role of hepatitis C virus and liver damage. Gastroenterology 106:1291-1300.
15. Matsuda J, Tsukamoto M, Gohchi K, Saitoh N, Gotoh M. 1994. Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) p24 antigen in the cryoglobulin of hemophiliacs with HIV and/or HCV infection [letter]. Clin Infect Dis 18:832-833.
16. Misiani R, Bellavita P, Fenili D, Borelli G, Marchesi D, Masazza M, Vendramin G, Comotti B, Tanzi E, Scudeller G. 1992. Hepatitis C virus infection in patients with essential mixed cryoglobulinemia. Ann Intern Med 117:573-577.
17. Misiani R, Bellavita P, Fenili D, Vicari M, Marchesini D, Sironi PL, Zilio P, Vernocchi A, Massazza M, Vendramin G, Tanzi E, Zanetti AR. 1994. Interferon alfa-2a therapy in cryoglobulinemia associated with hepatitis C virus. N Engl J Med 330:751-756.
18. Nagasaka A, Takahashi T, Sasaki T, Takimoto K, Miyashita K, Nakamura M, Wakahama O, Nishikawa S, Higuchi A. 2001. Cryoglobulinemia in Japanese patients with chronic hepatitis C virus infection: host genetic and virological study. J Med Virol 65:52-57.
19. Pawlotsky JM, Ben Yahia M, Andre C, Voisin MC, Intrator L, Roudot-Thoroval F, Deforges L, Duvoux C, Zaffrani ES, Duval J, Dhumeaux D. 1994. Immunological disorders in C virus chronic active hepatitis. A prospective case-control study. Hepatology 19:841-846.
20. Santagostino E, Colombo M, Cultraro D, Muça-Perja M, Gringeri A, Mannucci PM. 1998. High prevalence of serum cryoglobulins in multitransfused hemophilic patients. Blood 92:516-519.
21. Schmidt WN, Stapleton JT, LaBrecque DR, Mitros FA, Kirby PA, Perino Philips MJ, Brashear DL. 2000. Hepatitis C virus (HCV) infection and cryoglobulinemia: analysis of whole blood and plasma HCV-RNA concentrations and correlations with liver histology. Hepatology 31:737-744.
22. Viasoz S, Zilbert A, Ramakrishnan K, Widell A, Cavicchini A, Schreier E, Roggendorf M. 1994. Typing of hepatitis C virus isolates by DNA enzyme immunoassay. J Virol Methods 48:81-92.
23. Wong SV, Egner W, Elsey T, Brown D, Alexander GJM. 1996. Incidence, character and clinical relevance of mixed cryoglobulinemia in patients with chronic hepatitis C virus infection. Clin Exp Immunol 104:25-31.
24. Wilson RA. 1997. Extrahepatic manifestations of chronic viral hepatitis. Am J Gastroenterol 92:4-17.