Single- and repeated-dose pharmacokinetics of eplerenone, a selective aldosterone receptor blocker, in rats

Xenobiotica

Volumn 33, Issue 3, 2003, Pages 305-321

  Cook, C S ^a   Zhang, L ^a   Ames, G B ^a   Fischer, J ^a   Zhang, J ^a   Levin, S ^a  

^a Global Drug Metabolism   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE ANTAGONIST; CYTOCHROME P450 3A; DRUG METABOLITE; EPLERENONE; OXYGENASE; STEROID 6BETA HYDROXYLASE; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFECT; DRUG ELIMINATION; DRUG EXCRETION; DRUG FECES LEVEL; DRUG HALF LIFE; DRUG METABOLISM; DRUG URINE LEVEL; ENZYME ACTIVITY; PLASMA CLEARANCE; SEX DIFFERENCE;

ADMINISTRATION, ORAL; ALDOSTERONE ANTAGONISTS; ALKANE 1-MONOOXYGENASE; ANIMALS; BIOTRANSFORMATION; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; FECES; FEMALE; HALF-LIFE; INJECTIONS, INTRAVENOUS; MALE; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ALDOSTERONE; SEX FACTORS; SPIRONOLACTONE; SUBCELLULAR FRACTIONS;

STAPHYLOCOCCUS PHAGE 3A;

EID: 0037356967     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/0049825021000049277     Document Type: Article

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