Hydrogen peroxide-dependent declines in Bcl-2 induces apoptosis in hypoxic liver

Journal of Surgical Research

Volumn 110, Issue 1, 2003, Pages 211-216

  Motoyama, Satoru ^a   Saito, Satoshi ^a   Saito, Reijiro ^a   Minamiya, Yoshihiro ^a   Nakamura, Masakatsu ^a   Okuyama, Manabu ^a   Imano, Hiroshi ^a   Ogawa, Jun Ichi ^a  

^a AKITA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; Bcl 2; Hepatocyte; Hydrogen peroxide; Hypoxia; Immunoelectron microscopy; Liver; Mitochondria; Sinusoidal endothelial cell; Xanthine oxidase

Indexed keywords

8 [3 METHOXY 4 (PHENYLSULFINYL)PHENYL]PYRAZOLO[1,5 A][1,3,5]TRIAZIN 4 OL; HYDROGEN PEROXIDE; MITOCHONDRIAL PROTEIN; PROTEIN BCL 2; XANTHINE OXIDASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL LEVEL; CONTROLLED STUDY; ENDOTHELIUM CELL; ISOLATED LIVER; LIVER BLOOD FLOW; LIVER CELL; LIVER ISCHEMIA; LIVER PARENCHYMA; LIVER SINUSOID; MALE; NICK END LABELING; NONHUMAN; PARENCHYMA; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT;

EID: 0037356274     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-4804(03)00006-4     Document Type: Article

References (21)

1. Marotto M.E., Thurman R.G., Lemasters J.J. Early midzonal cell death during low-flow hypoxia in the isolated, perfused rat liver. Protection by allopurinol. Hepatology. 8:1988;585.
2. Suematsu M., Suzuki H., Ishii H., Kato S., Hamamatsu H., Miura S., Tsuchiya M. Topographic dissociation between mitochondrial dysfunction and cell death during low-flow hypoxia in perfused rat liver. Lab. Invest. 67:1992;434.
3. Suematsu M., Suzuki H., Ishii H., Kato S., Yanagisawa T., Asako H., Suzuki M., Tsuchiya M. Early midzonal oxidative stress preceding cell death in hypoperfused rat liver. Gastroenterology. 103:1992;994.
4. Suzuki H., Suematsu M., Ishii H., Kato S., Miki H., Mori M., Ishimura Y., Nishino T., Tsuchiya M. Prostaglandin E1 abrogates early reductive stress and zone-specific paradoxical oxidative injury in hypoperfused rat liver. J. Clin. Invest. 93:1994;155.
5. Motoyama S., Minamiya Y., Saito S., Saito R., Matsuzaki I., Abo S., Inaba H., Enomoto K., Kitamura M. Hydrogen peroxide derived from hepatocytes induced sinusoidal endothelial cells apoptosis in perfused hypoxic rat liver. Gastroenterology. 114:1998;153.
6. Motoyama S., Saito S., Alojado M.E., Ito H., Kitamura M., Suzuki H., Saito R., Momiyama H., Nakae H., Ogawa J., Inaba H. Hydrogen peroxide induces midzonal heat shock protein 72 apoptosis in sinusoidal endothelial cells of hypoperfused rat liver. Crit. Care Med. 28:2000;1509.
7. Motoyama S., Saito S., Inaba H., Kitamura M., Minamiya Y., Suzuki H., Saito R., Kamata R., Nakae H., Ogawa J. Red blood cells attenuate sinusoidal endothelial cell injury scavenging xanthine oxidase-dependent hydrogen peroxide In hyperoxic perfused liver. Liver. 20:2000;200.
8. Kroemer G. The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat. Med. 3:1997;614.
9. Hockenbery D., Nunez G., Milliman C.L., Schreiber R.D., Korsmeyer S.J. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature. 348:1990;334.
10. Akao Y., Otsuki Y., Kataoka S., Ito Y., Tujimoto Y. Multiple subcellular localization of bcl-2: Detection in nuclear outer membrane, endoplasmic reticulum, and mitochondrial membrane. Cancer Res. 54:1994;2468.
11. Motoyama S., Kitamura M., Saito S., Minamiya Y., Suzuki H., Saito R., Terada K., Ogawa J., Inaba H. Bcl-2 is located predominantly in the inner membrane and crista of mitochondria in rat liver. Biochem. Biophys. Res. Commun. 249:1998;628.
12. Motoyama S., Saito S., Inaba H., Ogawa J. Bcl-2 is located predominantly in the inner membrane and crista of mitochondria. Ebadi M., Marwash J., Chopra R.K. Mitochondrial Ubiquinone (Coenzyme Q10) Biochemical, Functional, Medical, and Therapeutic Aspect in Human Health and Disease. 2001;Prominent Press, Scottsdale, AZ.
13. Zamzami N., Susin S.A., Marchetti P., Hirsch T., Gomez-Monterrey I., Castedo M., Kroemer G. Mitochondrial control of nuclear apoptosis. J. Exp. Med. 183:1996;1533.
14. Yang J., Liu X., Bhalla K., Kim C.N., Ibrado A.M., Cai J., Peng T.I., Jones D.P., Wang X. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked. Science. 275:1997;1129.
15. Okamoto K., Nishino T. Mechanism of inhibition of xanthine oxidase with a new tight binding inhibitor. J. Biol. Chem. 270:1995;7816.
16. Tokuyasu K.T. Application of cryoultramicrotomy to immunocytochemistry. J. Microsc. 143:1986;139.
17. Tokuyasu K.T. Use of polyvinyl pyrrolidone and polyvinyl alcohol for cryoultramicrotomy. Histochem. J. 21:1989;163.
18. Burns A.R., Takei F., Doerschuk C.M. Quantification of ICAM-1 expression in mouse lung during pneumonia. J. Immunol. 153:1994;3189.
19. Jong D.D., Prins F.A., Mason D.Y., Reed J.C., Ommen G.B., Kluin P.M. Subcellular localization of the bcl-2 protein in malignant and normal lymphoid cells. Cancer Res. 54:1994;256.
20. Hyatt A.D., Wise T. Comparison of immunogold methodologies for the detection of low copy number viral antigens in bluetongue virus (BTV)-infected cells. Micron. 25:1994;597.
21. Tarmann T., Dohr G., Schiechl H., Barth S., Hartmann M. Immunohistochemical detection of an epithelial membrane protein in rat embryos at different stages of development. Acta Anat. Basel. 137:1990;141.