Optimization of cell growth and poly(glutamic acid) production in batch fermentation by Bacillus subtilis

Biotechnology Letters

Volumn 25, Issue 6, 2003, Pages 465-468

  Richard, Andrew ^a   Margaritis, Argyrios ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Biopolymer pharmaceuticals; Drug delivery; Fermentation; Paclitaxel; Poly(glutamic acid)

Indexed keywords

CITRIC ACID; GLUTAMIC ACID; GLYCEROL; POLYGLUTAMIC ACID;

ARTICLE; BACILLUS SUBTILIS; BIOREACTOR; BIOSYNTHESIS; CELL DIVISION; CHEMISTRY; CULTURE MEDIUM; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PH; PHYSIOLOGY; QUALITY CONTROL;

BACILLUS SUBTILIS; BIOREACTORS; CELL DIVISION; CITRIC ACID; CULTURE MEDIA; GLUTAMIC ACID; GLYCEROL; HYDROGEN-ION CONCENTRATION; POLYGLUTAMIC ACID; QUALITY CONTROL;

BACILLUS SUBTILIS;

EID: 0037352477     PISSN: 01415492     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022644417429     Document Type: Article

References (21)

1. Chemical and Engineering News (2002) States Sue Bristol-Myers over taxol generics. 80: 13.
2. Cromwick A-M, Birrer G, Gross R (1996) Effects of pH and aeration on γ-poly(glutamic acid) formation by Bacillus licheniformis in controlled batch fermentor cultures. Biotechnol. Bioeng. 50: 222-227.
3. Engel J, Deger W, Reissman T, Losse G, Naumann W, Murgas S (2000) Process for the preparation of immobilized and activity stabilized complexes of LHTH. US Patent No. 6,054,555.
4. Giannos S, Gross A (1990) Poly(glutamic acid) produced by bacterial fermentation. In: Kaplan D, Mayer J, eds. Novel Biodegradable Microbial Polymers. Kluwer Academic Publishers, Dordrecht, pp. 457-460.
5. Goto, A, Kunioka, M (1992) Biosynthesis and hydrolysis of poly(γ-glutamic acid) from Bacillus subtilis IFO3335. Biosci. Biotech. Biochem. 56: 1031-1035.
6. Hwan Do J, Chang H, Lee S (2001) Efficient recovery of poly(glutamic acid) from highly viscous culture broth. Biotechnol. Bioeng. 76: 219-223.
7. Iwata H, Matsuda S, Mitsuhashi K, Kenji I, Itoh E, Ikada Y (1998) A novel surgical glue composed of gelatin and N-hydroxysuccinimide activated poly(L-glutamic acid). Biomaterials 19: 1869-1876.
8. Ko Y, Gross R (1998) Effects of glucose and glycerol on γ-poly(glutamic acid) formation by Bacillus licheniformis ATCC 9945a. Biotechnol. Bioeng. 57: 430-437.
9. Kubota H, Matsunobu T, Uotani K, Takebe H, Satoh A, Tanaka T, Taniguchi M (1993) Production of poly(glutamic acid) by Bacillus subtilis F-2-01. Biosci. Biotech. Biochem. 57: 1212-1213.
10. Kunioka M, Goto A (1994) Biosynthesis of poly(γ-glutamic acid) from L-glutamic acid, citric acid, and ammonium sulfate in Bacillus subtilis IFO3335. Appl. Microbiol. Biotechnol. 40: 867-872.
11. Li C, Ke S, Wu Q-P, Tansey W, Hunter N, Buchmiller L, Milas L, Chamsangavej C, Wallace S (2000) Experimental therapeutics, preclinical pharmacology - Tumor irradiation enhances the tumor-specific distribution of poly(L-glutamic acid)-conjugated paclitaxel and its antitumor efficacy. Clin. Cancer. Res. 6: 2829-2834.
12. Li C, Wallace S, Yu, D-F, Yang D (1999) Water soluble paclitaxel prodrugs. US Patent No. 5,977,163.
13. Multani A, Li C, Ozen M, Yadav M, Yu D-F, Wallace S, Pathak S (1997) Paclitaxel and water-soluble poly(L-glutamic acid)-paclitaxel, induce direct chromosomal abnormalities and cell death in a murrine metastatic melanoma cell line. Anticancer Res. 17: 4269-4274.
14. Myers A, Bichon D (1992) Cytotoxic drug conjugates and their delivery to tumor cells. US Patent No. 5,087,616.
15. Otani Y, Tabata Y, Ikada Y (1996) A new biological glue from gelatin and poly(L-glutamic acid). J. Biomed. Mat. Res. 31: 157-165.
16. Otani Y, Tabata Y, Ikada Y (1999) Sealing effect of rapidly curable gelatin- poly(L-glutamic acid) hydrogel glue on lung air leak. Ann. Thorac. Surg. 67: 922-926.
17. Richard A, Margaritis A (2001) Poly(glutamic acid) for biomedical applications. CRC Crit. Rev. Biotechnol. 21: 219-232.
18. Richard A, Margaritis A (2003) Rheology, oxygen transfer and molecular weight characteristics of poly(glutamic acid) fermentation by Bacillus subtilis. Biotech. Bioeng., in press.
19. Sakurai Y, Okano T, Kataoka K, Yamada N, Inoue S, Yokoyama M (1997) Water soluble high molecular weight polymerized drug preparation. US Patent No. 5,693,751.
20. Sgouras D, Duncan R (1994) Evaluation of poly(glutamic acid, alanine, tyrosine) (1:1:1) as a lung-specific drug delivery system I. Biocompatibility and studies on biodistribution in the rat. STP Pharm. Sci. 4: 87-94.
21. Yoon S, Do J, Lee S, Chang H (2000) Production of poly-γ-glutamic acid by fed-batch culture of Bacillus licheniformis. Biotechnol. Lett. 22: 585-588.