P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) are induced by arsenic trioxide (As2O3), but are not the main mechanism of As2O3-resistance in acute promyelocytic leukemia cells [7]

Leukemia

Volumn 17, Issue 3, 2003, Pages 648-650

  Takeshita, A ^a   Shinjo, K ^a   Naito, K ^a   Matsui, H ^a   Shigeno, K ^a   Nakamura, S ^a   Horii, T ^a   Maekawa, M ^a   Kitamura, K ^b   Naoe, T ^b   Ohnishi, K ^a   Ohno, R ^c  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

^c AICHI CANCER CENTER HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARSENIC TRIOXIDE; BUTHIONINE SULFOXIMINE; DOXORUBICIN; GLUTATHIONE; GLYCOPROTEIN P; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1;

BLAST CELL; CANCER CELL CULTURE; CANCER RECURRENCE; CANCER REGRESSION; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; LETTER; LEUKEMIA CELL; MULTIDRUG RESISTANCE; NUCLEOTIDE SEQUENCE; OUTCOMES RESEARCH; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION;

EID: 0037350539     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402851     Document Type: Letter

References (8)

1. Kitamura K, Minami Y, Yamamoto K, Akao Y, Kiyoi H, Saito H et al. Involvement of CD95-independent caspase 8 activation in arsenic trioxide-induced apoptosis. Leukemia 2000; 14: 1743-1750.
2. Liu J, Miller DS, Saavedra JE, Keefer LK, Johnson DR, Klaassesn CD et al. Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic. Mol Pharmacol 2001; 60: 302-309.
3. Vernhet L, Seite M-P, Allain N, Guillouzo A, Fardel O. Arsenic induces expression of the multidrug resistance-associated protein 2 (MRP2) gene in primary rat and human hepatocytes. J Pharm Exp Ther 2001; 298: 234-239.
4. Lorico A, Bertola A, Baum C, Fodstad O, Rappa G. Role of the multidrug resistance protein 1 in protection from heavy metal oxyanions: investigations in vitro and MRP1-deficient mice. Biochem Biophys Res Commun 2002; 291: 617-622.
5. Takeshita A, Shinjo K, Naito K, Ohnishi K, Sugimoto Y, Yamakawa Y et al. Role of P-glycoprotein in all-trans retinoic acid (ATRA) resistance in acute promyelocytic leukaemia cells: analysis of intracellular concentration of ATRA. Br J Haematol 2000; 108: 90-92.
6. Matsui H, Takeshita A, Naito K, Shinjo K, Shigeno K, Maekawa M et al. Reduced effect of gemtuzumab ozogamicin (CMA-676) on P-glycoprotein and/or CD34-positive leukemia cells and its restoration by multidrug-resistance modifiers. Leukemia 2002; 16: 813-819.
7. Perkins C, Kim CN, Fang G, Bhalla N. Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-abl or overexpress MDR, MRP, Bcl-2, or Bcl-xL. Blood 2000; 95: 1014-1022.
8. 3) on leukemic cells from patients with non-M3 acute myelogenous leukemia: studies of cytotoxicity, apoptosis and the pattern of resistance. Eur J Haematol 2001; 66: 357-364.