A small population of vasculitogenic T cells expands and has skewed T cell receptor usage after culture with syngeneic smooth muscle cells

Journal of Autoimmunity

Volumn 20, Issue 2, 2003, Pages 125-133

  Swanson, Brad J ^a,b   Baiu, Dana C ^a   Sandor, Matyas ^a   Fabry, Zsuzsa ^a   Hart, Michael N ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Animal model; CD4+ T cells; CDR spectratype; TCR transgenic; Vasculitis

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; EPITOPE; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR;

ANALYSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL SPECIFICITY; CELL SURVIVAL; COCULTURE; CONTROLLED STUDY; IMMUNE RESPONSE; LUNG; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE TRANSFER; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; T LYMPHOCYTE SUBPOPULATION; VASCULITIS;

EID: 0037347317     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-8411(02)00113-0     Document Type: Article

References (28)

1. Kallenberg C.G., Heeringa P. Pathogenesis of vasculitis. Lupus. 7:1998;280-284.
2. Le Hello C. Vasculitis associated with antiviral vaccines and antiviral agents. Pathol Biol (Paris). 47:1999;252-256.
3. Bajema I.M., Hagen E.C. Evolving concepts about the role of antineutrophil cytoplasm autoantibodies in systemic vasculitides. Curr Opin Rheumatol. 11:1999;34-40.
4. Savage C.O., Harper L., Holland M. New findings in pathogenesis of antineutrophil cytoplasm antibody-associated vasculitis. Curr Opin Rheumatol. 14:2002;15-22.
5. Mandell B.F., Calabrese L.H. Infections and systemic vasculitis. Curr Opin Rheumatol. 10:1998;51-57.
6. Nowack R., Flores-Suarez L.F., van der Woude F.J. New developments in pathogenesis of systemic vasculitis. Curr Opin Rheumatol. 10:1998;3-11.
7. Cohen Tervaert J.W., Popa E.R., Bos N.A. The role of superantigens in vasculitis. Curr Opin Rheumatol. 11:1999;24-33.
8. Hart M.N., Tassell S.K., Sadewasser K.L., Schelper R.L., Moore S.A. Autoimmune vasculitis resulting from in vitro immunization of lymphocytes to smooth muscle. Am J Pathol. 119:1985;448-455.
9. Fabry Z., Waldschmidt M.M., Van Dyk L., Moore S.A., Hart M.N. Activation of CD4+ lymphocytes by syngeneic brain microvascular smooth muscle cells. J Immunol. 145:1990;1099-1104.
10. Hart M.N., Waldschmidt M.M., Hanley-Hyde J.H., Moore S.A., Kemp J.D., Schelper R.L. Brain microvacular smooth muscle expresses class II antigens. J Immunol. 138:1987;2960-2963.
11. Pardridge W.M., Yang J., Buciak J., Tourtellotte W.W. Human brain microvascular DR-antigen. J Neurosci Res. 23:1989;337-341.
12. Fabry Z., Waldschmidt M.M., Moore S.A., Hart M.N. Antigen presentation by brain microvessel smooth muscle and endothelium. J Neuroimmunol. 28:1990;63-71.
13. Fabry Z., Sandor M., Gajewski T.F., Herlein J.A., Waldschmidt M.M., Lynch R.G., et al. Differential activation of Th1 and Th2 CD4+ cells by murine brain microvessel endothelial cells and smooth muscle/pericytes. J Immunol. 151:1993;38-47.
14. Moore S.A., Strauch A.R., Yoder E.J., Rubenstein P.A., Hart M.N. Cerebral microvascular smooth muscle in tissue culture. In Vitro. 20:1984;512-520.
15. Lyons A.B., Parish C.R. Determination of lymphocyte division by flow cytometry. J Immunol Methods. 171:1994;131-137.
16. Parish C.R. Fluorescent dyes for lymphocyte migration and proliferation studies. Immunol Cell Biol. 77:1999;499-508.
17. Lehmann P.V., Drexler K., Tary-Lehmann M., Falcioni F., Hurtenbach U., Nagy Z.A. Graft-versus-host resistance induced by class II major histocompatibility complex-specific T cell clones. J Exp Med. 173:1991;333-341.
18. Murphy K.M., Heimberger A.B., Loh D.Y. Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science. 250:1990;1720-1723.
19. Marrack P., Winslow G.M., Choi Y., Scherer M., Pullen A., White J., et al. The bacterial and mouse mammary tumor virus superantigens; two different families of proteins with the same functions. Immunol Rev. 131:1993;79-92.
20. Savage P.A., Boniface J.J., Davis M.M. A kinetic basis for T cell receptor repertoire selection during an immune response. Immunity. 10:1999;485-492.
21. +T cells. J Exp Med. 194:2001;1711-1719.
22. Fabry Z., Fitzsimmons K.M., Herlein J.A., Moninger T.O., Dobbs M.B., Hart M.N. Production of the cytokines interleukin 1 and 6 by murine brain microvessel endothelium and smooth muscle pericytes. J Neuroimmunol. 47:1993;23-34.
23. Hart M.N., Fabry Z., Love-Homan L., Keiner J., Sadewasser K.L., Moore S.A. Brain microvascular smooth muscle and endothelial cells produce granulocyte macrophage colony-stimulating factor and support colony formation of granulocyte-macrophage-like cells. Am J Pathol. 141:1992;421-427.
24. McHugh R.S., Shevach E.M. Cutting edge: depletion of CD4+CD25+ regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease. J Immunol. 168:2002;5979-5983.
25. Hart M.N., Fabry Z. CNS antigen presentation. Trends Neurosci. 18:1995;475-481.
26. Stemme S., Patarroyo M., Hansson G.K. Adhesion of activated T lymphocytes to vascular smooth muscle cells and dermal fibroblasts is mediated by beta 1-and beta 2-integrins. Scand J Immunol. 36:1992;233-242.
27. Thomas W.E. Brain macrophages: on the role of pericytes and perivascular cells. Brain Res Brain Res Rev. 31:1999;42-57.
28. Fabry Z., Waldschmidt M.M., Hendrickson D., Keiner J., Love-Homan L., Takei F., et al. Adhesion molecules on murine brain microvascular endothelial cells: expression and regulation of ICAM-1 and Lgp 55. J Neuroimmunol. 36:1992;1-11.