Synthesis and in vivo biodisposition of [14C]-quaternary ammonium-melphalan conjugate, a potential cartilage-targeted alkylating drug

Bioconjugate Chemistry

Volumn 14, Issue 2, 2003, Pages 500-506

  Rapp, Maryse ^a   Giraud, Isabelle ^a   Maurizis, Jean Claude ^a   Galmier, Marie Josèphe ^a   Madelmont, Jean Claude ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDES; DRUG INTERACTIONS; HISTOLOGY; RADIATION; RADIOACTIVITY;

% REDUCTIONS; ANTICANCER DRUG; CARTILAGINOUS TISSUES; CHONDROSARCOMA; IN-VIVO; MELPHALAN; QUATERNARY AMMONIUM; SIDE EFFECT; SYNTHESISED; THERAPEUTIC INDEX;

CARTILAGE;

4 [BIS(2 CHLOROETHYL)AMINO]PHENYLALANINE MELPHALAN; ALKYLATING AGENT; AMIDE; ANTINEOPLASTIC AGENT; CARBON 14; DRUG METABOLITE; MELPHALAN; QUATERNARY AMMONIUM DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARTILAGE; CHEMICAL BOND; CHONDROSARCOMA; CONJUGATION; CONTROLLED STUDY; DRUG ELIMINATION; DRUG EXCRETION; DRUG FECES LEVEL; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TARGETING; DRUG TISSUE LEVEL; IN VIVO STUDY; ISOTOPE LABELING; MALE; NONHUMAN; RADIOACTIVITY; RAT; URINARY EXCRETION;

ANIMALIA;

EID: 0037344040     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc020031e     Document Type: Article

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