Comparison of abortions induced by methotrexate or mifepristone followed by misoprostol

Obstetrics and Gynecology

Volumn 99, Issue 5, 2002, Pages 813-819

  Wiebe, Ellen ^a   Dunn, Sheila ^a   Guilbert, Edith ^a   Jacot, Francis ^a   Lugtig, Lisa ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CODEINE; DIMENHYDRINATE; FOLIC ACID; IBUPROFEN; INFUSION FLUID; METHOTREXATE; METHYLERGOMETRINE MALEATE; MIFEPRISTONE; MISOPROSTOL; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; STEROID; WARFARIN;

ADULT; ARTICLE; BLEEDING; CHILL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; FEMALE; FEVER; HEADACHE; HUMAN; INDUCED ABORTION; INFECTION; MAJOR CLINICAL STUDY; MULTICENTER STUDY; NAUSEA; PAIN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SUCTION; TREATMENT OUTCOME; VOMITING;

ABORTIFACIENT AGENTS, NONSTEROIDAL; ABORTIFACIENT AGENTS, STEROIDAL; ABORTION, INDUCED; ADULT; FEMALE; HEMORRHAGE; HUMANS; METHOTREXATE; MIFEPRISTONE; MISOPROSTOL; PAIN; PREGNANCY;

EID: 0036224183     PISSN: 00297844     EISSN: 1873233X     Source Type: Journal    
DOI: 10.1016/s0029-7844(02)01944-0     Document Type: Article

References (38)

1. World Health Organization. Medical methods for termination of pregnancy. Report of a WHO Scientific Group. Geneva: World Health Organization, 1997:19-22.
2. Creinin MD, Vittinghoff E, Galbraith S, Klaisle C. Methotrexate and misoprostol for early abortion: A randomized trial comparing misoprostol 3 days and 7 days following methotrexate. Am J Obstet Gynecol 1995;173:137-43.
3. Creinin MD, Park M. Acceptability of medical abortion with methotrexate and misoprostol. Contraception 1995; 52:41-4.
4. Johannisson E, Oberholzer M, Swahn ML, Bygdeman M. Vascular changes in the human endometrium following the administration of the progesterone antagonist RU 486. Contraception 1989;39:103-17.
5. 2 in separated cells from early human decidua. J Clin Endocrin Metab 1987;65:527-34.
6. Bygdeman M, Swahn ML. Progesterone receptor blockage. Effect on uterine contractility and early pregnancy. Contraception 1985;32:45-51.
7. DeLoia JA, Stewart-Akers AM, Creinin MD. Effects of methotrexate on trophoblast proliferation and local immune responses. Hum Reprod 1998;13:1963-9.
8. Compendium of Pharmaceuticals and Specialties. 33rd ed. 1998.
9. Norman JE, Thong KJ, Baird DT. Uterine contractility and induction of abortion in early pregnancy by misoprostol and mifepristone. Lancet 1991;338:1233-6.
10. World Health Organization. Induced abortion. Report of a WHO Scientific Group. WHO Technical Report Series no. 623. Geneva: World Health Organization.
11. Peyron R, Aubeny E, Tarzus V, Silvestre L, Renault M, Elkik F, et al. Early termination of pregnancy with mifepristone (RU 486) and orally active prostaglandin misoprostol. N Engl J Med 1993;328:1509-13.
12. Sylvestre L, Dubois C, Renault M, Rezvani Y, Baulieu E-E, Ulmann A. Voluntary interruption of pregnancy with mifepristone (RU 486) and a prostaglandin analogue: A large-scale French experience. N Engl J Med 1990;322:645-8.
13. Spitz I, Bardin CW, Benton L, Robbins A. Early pregnancy termination with mifepristone and misoprostol in the United States. N Engl J Med 1998;338:1241-7.
14. Schaff EA, Stadalius LS, Eisinger SH, Franks P. Vaginal misoprostol administered at home after mifepristone (RU 486) for abortion. J Fam Pract 1997;44:353-60.
15. Creinin MD, Darney PD. Methotrexate and misoprostol for early abortion. Contraception 1993;48:339-48.
16. Wiebe ER. Abortion induced with methotrexate and misoprostol. Can Med Assoc J 1996;154:165-70.
17. Wiebe ER. Choosing between surgical abortions and medical abortions induced with methotrexate and misoprostol. Contraception 1997;55:67-71.
18. Wiebe ER. Abortion induced with methotrexate and misoprostol: A comparison of various protocols. Contraception 1997;55:159-63.
19. Hausknecht RU. Methotrexate and misoprostol to terminate early pregnancy. N Engl J Med 1995;333:337-40.
20. Schaff E, Eisinger SH, Franks P, Kim SS. Methotrexate and misoprostol for early abortion. Fam Med 1996;28:196-9.
21. Creinin MD, Vittinghoff E, Keder L, Darney PD, Tiller G. Methotrexate and misoprostol for early abortion. A multicenter trial. I. Safety and efficacy. Contraception 1995; 53:321-7.
22. Creinin MD. Methotrexate and misoprostol for abortion at 57-63 days' gestation. Contraception 1994;50:511-5.
23. Carbonell JLL, Varela L, Velazco A, Cabezas E, Fernandez C, Sanches C. Oral methotrexate and vaginal misoprostol for early abortion. Contraception 1998;57:83-8.
24. Creinin MD, Carbonell JLL, Schwartz JL, Varela L, Tanda R. A randomized trial of the effect of moistening misoprostol before vaginal administration when used with methotrexate for abortion. Contraception 1999;59:11-6.
25. National Abortion Federation. Recommended guidelines for use of methotrexate and misoprostol in early abortion. National Abortion Federation: Washington, DC; 1996.
26. Davis VJ, Francoeur D, Grant L, Parish B, Steben M. Guidelines for medical termination of early pregnancy. J Soc Obstet Gynecol Can 1999;82:1169-73.
27. Rossavik IK, Torjusen GO, Gibbons WE. Conceptual age and ultrasound measurements of gestational sac and crown-rump length in vitro fertilization pregnancies. Fertil Steril 1988;49:1012-7.
28. Goldstein SR, Wolfson R. Endovaginal ultrasonographic measurements of early embryonic size as a means of assessing gestational age. J Ultrasound Med 1994;13:27-31.
29. Wiebe ER. Misoprostol administration in medical abortion. A comparison of three regimens. J Reprod Med 2001;46:125-9.
30. Wiebe ER, Rawling M. Pain control in abortion. Int J Gynecol Obstet 1995;50:41-6.
31. Jensen MP, Karoly P, Braver S. The measurement of clinical pain intensity: A comparison of six methods. Pain 1986;27:117-26.
32. el-Rafaey H, Rajasekar D, Abdalla M, Calder L, Templeton A. Induction of abortion with mifepristone (RU 486) and oral or vaginal misoprostol. N Engl J Med 1995;332:983-7.
33. Schaff EA, Eisinger SH, Stadalius LS, Franks P, Gore B, Poppema S. Low dose mifepristone 200 mg and vaginal misoprostol for abortion. Contraception 1999;59:1-6.
34. Tang GW, Lau W, Yip P. Further acceptability evaluation of RU486 and ONO 802 as abortifacient agents in a Chinese population. Contraception 1993;48:267-76.
35. Bachelot A, Cludy L, Spira A. Conditions for choosing between drug-induced and surgical abortions. Contraception 1992;45:547-59.
36. Holmgren K. Women's evaluation of three early abortion methods. Acta Obstet Gynecol Scand 1992;71:616-23.
37. Winikoff B, Sivin I, Kurus J, Cabezas E, Xiao B, Gu S, et al. Safety, efficacy, and acceptability of medical abortion in China, Cuba, and India: A comparative trial of mifepristone-misoprostol versus surgical abortion. Am J Obstet Gynecol 1997;176:431-7.
38. Rawling MJ, Wiebe ER. Randomized controlled trial of fentanyl for abortion pain. Am J Obstet Gynecol 2001;185:103-7.