Danazol administration after gonadotrophin-releasing hormone analogue reduces rebound of uterine myomas

Human Reproduction

Volumn 12, Issue 2, 1997, Pages 357-360

  De Leo, V ^a   Morgante, G ^a   Lanzetta, D ^a   D'Antona, D ^a   Bertieri, R S ^b  

^a UNIVERSITY OF SIENA   (Italy)

^b Department S S F A ^*  (Italy)

Author keywords

Danazol; GnRHa; Myomas; Oestradiol; Progesterone

Indexed keywords

DANAZOL; ESTRADIOL; FOLLITROPIN; GONADORELIN DERIVATIVE; GONADOTROPIN; LUTEINIZING HORMONE; PROGESTERONE; PROLACTIN;

ADULT; AMENORRHEA; ARTICLE; BONE MINERAL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ENDOCRINE FUNCTION; ESTRADIOL BLOOD LEVEL; FEMALE; FOLLITROPIN BLOOD LEVEL; GONADOTROPIN BLOOD LEVEL; HUMAN; LUTEINIZING HORMONE BLOOD LEVEL; MENSTRUAL CYCLE; ORGAN SIZE; OVARY FUNCTION; PROGESTERONE BLOOD LEVEL; PROLACTIN BLOOD LEVEL; UTERUS; UTERUS MYOMA;

EID: 0030938370     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/12.2.357     Document Type: Article

References (27)

1. Andreyko, J.L., Blumenfeld, Z., Marshall, L.A. et al. (1988) Use of an agonist analogue of gonadotropin-releasing hormone (nafarelin) to treat leiomyomas: assessment by magnetic resonance imaging. Am. J. Obstet. Gynecol., 158, 903-910.
2. Barbieri, R.L., Lee, H. and Ryan, K.J. (1979) Danazol binding to rat androgen, glucocorticoid, progesterone and oestrogen receptors. Fertil. Steril., 31, 182-186.
3. Berkeley, A.S., DeCherney, A.M. and Polan, M.L. (1983) Abdominal myomectomy and subsequent infertility. Surg. Gynecol. Obstet., 156, 319-322.
4. Buchi, K. and Keller, P.J. (1980) Oestrogen receptors in normal and myomatous human uteri. Gynaecol Obstet. Invest., 11, 59-63.
5. Buchi, K. and Keller, P.J. (1983) Cytoplastic progestins receptors in myomal and myometrial tissues. Acta Obstet. Gynaecol. Scand., 62, 487-492.
6. Buttram, V.C. Jr and Reiter, R.C. (1981) Uterine leiomyomata: etiology, symptomology and management. Fertil. Steril., 36, 433-445.
7. Carr, B.R., Marshburn, P.B., Weatherall, P. T. et al. (1993) An evaluation of the effect of gonadotropin-releasing hormone analogs and medroxyprogesterone acetate on uterine leiomyomata volume by magnetic resonance imaging: a prospective, randomized, double blind, placebo-controlled, crossover trial. J. Clin. Endocrinol. Metab., 76, 1217-1223.
8. Chamnes, G.C., Asch, R.H. and Pauerstein, C.J. (1980) Danazol binding and translocation of steroid receptors. Am. J. Obstet. Gynecol., 136, 426-431.
9. Comite, F. and Jenson, P. (1988) Bone density changes associated with GnRH analogues. Gynecol. Endocrinol., 2, abstract 095.
10. Countinho, E.M. and Goncalves, M.T. (1989) Long-term treatment of leiomyomas with gestrinone. Fertil. Steril., 51, 939-946.
11. De Leo, V., Lanzetta, D., Petrilli, S. et al. (1992) Efficacy of treatment with GnRH agonists in women with menometrorrhagia. Ginecol. Endocrinol., 6, 89-91.
12. Dmowski, W.P. and Cohen, M.R. (1975) Treatment of endometriosis with an antigonadotropin, danazol: a laparoscopic and histologic evaluation. Obstet. Gynecol., 46, 174-177.
13. Dmowski, W.P., Headly, S. and Radwanska, E. (1983) Effects of danazol on pulsatile gonadotropin patterns and on serum estradiol levels in normally cycling women. Fertil. Steril., 39, 49-55.
14. Filicori, M., Hall, D.A. et al. (1983) A conservative approach to the management of uterine leiomyomata: pituitary desensitization by a luteinizing homone-releasing hormone analogue. Am. J. Obstet. Gynecol., 147, 726-727.
15. Franchimont, P. and Cramilion, C. (1977) The effects of danazol on anterior pituitary function. Fertil. Steril., 28, 814-818.
16. Friedman, A.J., Barbieri, R.L., Benacerraf, B.R. and Schiff, I. (1987) Treatment of leiomyomata with intranasal or subcutaneous leuprolide, a gonadotropin-releasing hormone agonist. Fertil. Steril., 48, 560-564.
17. Friedman, A.J., Barbieri, R.L. Doubilet, P.M., Fine, C. and Schiff, I. (1988): A randomized double blind trial of a gonadotrophin releasing hormone agonist (leuprolide) with or without medroxy progesterone acetate in the treatment of leiomyomata uteri. Fertil. Steril., 49, 404-409.
18. Letterie, G.S., Coddington, C.C., Winkel, C.A. et al. (1989) Efficacy of a gonadotropin-releasing hormone agonist in the treatment of uterine leiomyomata: long term follow-up. Fertil. Steril., 51, 951-956.
19. Maheux, R., Lemay, A. and Merat, P. (1986) Use of intranasal luteinizing hormone-releasing hormone agonist in uterine leiomyomas. Fertil. Steril., 47, 229-233.
20. Mixon, W.T. and Hammond, D.O. (1961): Response of myomas to a progestin. Am. J. Obstet. Gynecol., 82, 754-760.
21. Murphy, A.A., Kettel, L.M., Morales, A.J. et al. (1993): Regression of uterine leiomyomata in response to the antiprogesterone RU 486. J. Clin. Endocrinol. Metab., 76, 513-517.
22. Rein, M.S., Barbieri, R.L. and Friedman, A.J. (1995) Progesterone: a critical role in the pathogenesis of uterine myomas. Am. J. Obstet. Gynecol., 172, 14-19.
23. Sadan MR, Vaniddekinge B., Van Glederen, C.J. et al. (1987) Oestrogen and progesterone receptor concentrations in leiomyoma and normal myometrium. Ann. Clin. Biochem., 24, 263-267.
24. Soules, M.R.and McCarty, K.S. (1982) Leiomyomas steroid receptor content. Am. J. Obstet. Gynecol., 143, 6-11.
25. Tamaya, T., Fujimoto, J. and Okada, H. (1985) Comparison of cellular levels of steroid receptors in uterine leiomyomata and myometrium. Acta Obstet. Gynaecol. Scand., 64, 307-309.
26. Vollenhoven, B.J., Lawrence, A.S. and Healy, D.L. (1990) Uterine fibroids: a clinical review. Br. J. Obstet. Gynaecol. 97, 285-287.
27. Wilson, E.A., Yang, F. and Rees, D. (1980) Estradiol and progesterone binding in uterine leiomyomata and in normal uterine tissues. Obstet. Gynaecol., 55, 20-23.