Disposition kinetics of α-tocopherol in apolipoprotein B knockout mice

Pharmaceutical Research

Volumn 20, Issue 3, 2003, Pages 368-372

  Yokogawa, Koichi ^a   Shima, Yuichiro ^a   Hashimoto, Tomoka ^a   Hiyajyo, Makoto ^a   Kadoyama, Kaori ^a   Ishizaki, Junko ^a   Nomura, Masaaki ^a   Miyamoto, Ken Ichi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

tocopherol; Abetalipoproteinemia; Apolipoprotein B; Disposition kinetics; Knockout mice

Indexed keywords

ALPHA TOCOPHEROL; APOLIPOPROTEIN B;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BILIARY EXCRETION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE CALCULATION; DRUG DISPOSITION; FEMALE; GAS CHROMATOGRAPHY; INTESTINE ABSORPTION; KNOCKOUT MOUSE; MALE; MASS SPECTROMETRY; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; STEADY STATE; TISSUE LEVEL; VITAMIN BLOOD LEVEL; WILD TYPE;

ADMINISTRATION, ORAL; ALPHA-TOCOPHEROL; ANIMALS; ANTIOXIDANTS; APOLIPOPROTEINS B; AREA UNDER CURVE; BILE; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; INJECTIONS, INTRAVENOUS; MALE; MICE; MICE, KNOCKOUT; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 0037337676     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022691718226     Document Type: Article

References (27)

1. D. J. Rader and H. B. Brewer, Jr. ABL (new insights into lipoprotein assembly and vitamin E metabolism from a rare genetic disease). JAMA 270:865-869 (1993).
2. R. E. Gregg and J. R. Wetterau. The molecular basis of ABL. Curr. Opin. Lipido. 5:81-86 (1994).
3. C. C. Shoulders, D. J. Brett, J. D. Bayliss, T. M. E. Narcisi, A. Jarmuz, T. T. Grantham, P. R. D. Leoni, S. Bhattacharya, R. J. Pease, P. M. Cullen, S. Levi, P. G. H. Byfield, P. Purkiss, and J. Scott. ABL is caused by defects of the gene encoding the 97 kDa subunit of a microsomal triglyceride transfer protein. Hum. Mol. Genet. 2:2109-2116 (1993).
4. D. Sharp, L. Blinderman, K. A. Combs, B. Kienzle, B. Ricci, K. Wager-Smith, C. M. Gil, C. W. Turck, M.-E. Bouma, D. J. Rader, L. P. Aggerbeck, R. E. Gregg, D. A. Gordon, and J. R. Watterau. Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia. Nature 365:65-69 (1993).
5. J. R. Wetterau, L. P. Aggerbeck, M. E. EBouma, C. Eisenberg, A. Munck, M. Hermier, J. Schmitz, G. Gay, D. J. Rader, and R. E. Gregg. Absence of microsomal triglyceride transfer protein in individuals with ABL. Science 258:999-1001 (1992).
6. D. A. Gordon. and H. Jamil. Progress towards understanding the role of microsomal triglyceride transfer protein in apolipoprotein-B lipoprotein assembly. Biochim. Biophys. Acta 1486:72-83 (2000).
7. K. Ohashi, S. Ishibashi, J. Osuga, R. Tozawa, K. Harada, N. Yahagi, F. Shionoiri, Y. Iizuka, Y. Tamura, R. Nagai, D. R. Illingworth, T. Gotoda, and N. Yamada. Novel mutations in the microsomal triglyceride transfer protein gene causing ABL. J. Lipid Res. 41:1199-1204 (2000).
8. X. P. Yang, A. Inazu, K. Yagi, K. Kajinami, J. Koizumi, and H. Mabuchi. Abetalipoproteinemia caused by maternal isodisomy of chromosome 4q containing an intron 9 splice acceptor mutation in the microsomal triglyceride transfer protein gene. Arterioscler. Thromb. Vasc. Biol. 19:1950-1955 (1999).
9. R. Brigelius-Flohe and M. G. Traber. Vitamin E: function and metabolism. FASEB J. 13:1145-1155 (1999).
10. H. J. Kayden and M. G. Traber. Absorption, lipoprotein transport, and regulation of plasma concentrations of vitamin E in humans. J. Lipid Res. 34:343-358 (1993).
11. I. Ikeda, Y. Imasato, E. Sasaki, and M. Sugano. Lymphatic transport of alpha-, gamma- and delta-tocotrienols and alpha-tocopherol in rats. Int. J. Vitam. Nutr. Res. 66:217-221 (1996).
12. M. G. Traber and H. Arai. Molecular mechanisms of vitamin E transport. Annu. Rev. Nutr. 19:343-355 (1999).
13. G. E. Homanics, T. J. Smith, S. H. Zhang, D. Lee, S. G. Young, and N. Maeda. Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice. Proc. Natl. Acad. Sci. USA 90:2389-2393 (1993).
14. M. Nakanishi, K. Tsuchiya, K. Sakaguchi, and T. Fujita. Simultaneous determination of α-tocopherol and α-tocopheryl acetate in plasma by mass fragmentography. Yakugaku Zasshi 99:1037-1041 (1979).
15. K. Yamaoka, Y. Tanigawara, T. Nakagawa, and T. Uno. A pharmacokinetic analysis program (MULTI) for microcomputer. J. Pharmacobiodyn. 4:879-885 (1981).
16. H. J. Kayden, L. J. Hatam, and M. G. Traber. The measurement of nanograms of tocopherol from needle aspiration biopsies of adipose tissue: normal and abetalipoproteinemic subjects. J. Lipid Res. 24:652-656 (1983).
17. M. G. Traber, D. Rader, R. V. Acuff, H. B. Brewer, Jr., and H. J. Kayden. Discrimination between RRR- and all-racemic-alpha-tocopherols labeled with deuterium by patients with abetalipoproteinemia. Atherosclerosis 108:27-37 (1994).
18. W. Cohn. Bioavailability of vitamin E. Eur. J. Clin. Nutr. 51:S80-S85 (1997).
19. K. M. Wasan and S. M. Cassidy. Role of plasma lipoproteins in modifying the biological activity of hydrophobic drugs. J. Pharm. Sci. 87:411-424 (1998).
20. D. Goti, H. Reicher, E. Malle, G. M. Kostner, U. Panzenboeck, and W. Sattler. High-density lipoprotein (HDL3)-associated alpha-tocopherol is taken up by HepG2 cells via the selective uptake pathway and resecreted with endogenously synthesized apolipoprotein B-rich lipoprotein particles. Biochem. J. 332:57-65 (1998).
21. S. Acton, A. Rigotti, K. T. Landschulz, S. Xu, H. H. Hobbs, and M. Krieger. Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Science 271:518-520 (1996).
22. A. Bjorneboe, G. E. Bjorneboe, B. F. Hagen, J. O. Nossen, and C. A. Drevon. Secretion of alpha-tocopherol from cultured rat hepatocytes. Biochim. Biophys. Acta 922:199-205 (1987).
23. W. Cohn, F. Loechleiter, and F. Weber. Alpha-tocopherol is secreted from rat liver in very low density lipoproteins. J. Lipid Res. 29:1359-1366 (1988).
24. M. G. Traber. Regulation of human plasma vitamin E. Adv. Pharmacol. 38:49-63 (1997).
25. M. Birringer, D. Drogan, and R. Brigelius-Flohe. Tocopherols are metabolized in HepG2 cells by side chain omega-oxidation and consecutive beta-oxidation. Free Radic. Biol. Med. 31:226-232 (2001).
26. R. S. Parker, T. J. Sontag, and J. E. Swanson. Cytochrome P4503A-dependent metabolism of tocopherols and inhibition by sesamin. Biochem. Biophys. Res. Commun. 277:531-534 (2000).
27. M. Schuelke, A. Elsner, B. Finckh, A. Kohlschutter, C. Hubner, and R. Brigelius-Flohe. Urinary alpha-tocopherol metabolites in alpha-tocopherol transfer protein-deficient patients. J. Lipid Res. 41:1543-1551 (2000).