The influence of organ donor factors on early allograft function

Current Opinion in Urology

Volumn 13, Issue 2, 2003, Pages 99-104

  Schwarz, Christoph ^a   Oberbauer, Rainer ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Acute renal failure; Donor; Graft survival; Kidney; Transplantation

Indexed keywords

CELL ADHESION MOLECULE; CYTOKINE; NITRIC OXIDE;

ACUTE KIDNEY FAILURE; ALLOGRAFT; APOPTOSIS; CELL DAMAGE; DATA ANALYSIS; GENE EXPRESSION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; ORGAN DONOR; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REPERFUSION; REVIEW;

APOPTOSIS; CELL ADHESION MOLECULES; CYTOKINES; GRAFT SURVIVAL; HUMANS; KIDNEY; KIDNEY FAILURE, ACUTE; KIDNEY TRANSPLANTATION; LIVING DONORS; OXIDATIVE STRESS; RISK FACTORS; TISSUE DONORS;

EID: 0037336643     PISSN: 09630643     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042307-200303000-00003     Document Type: Review

References (53)

1. Ojo AO, Wolfe RA, Held PJ, et al. Delayed graft function: risk factors and implications for renal allograft survival. Transplantation 1997; 63:968-974.
2. Ojo AO, Hanson JA, Meier-Kriesche H, et al. Survival in recipients of marginal cadaveric donor kidneys compared with other recipients and wait-listed transplant candidates. J Am Soc Nephrol 2001; 12:589-597. The multivariate analysis of approximately 42 000 patients' data from the United Sates Renal Data System registry revealed ARF as the main risk factor for reduced long-term graft survival.
3. Nankivell BJ, Fenton-Lee CA, Kuypers DR, et al. Effect of histological damage on long-term kidney transplant outcome. Transplantation 2001; 71:515-523.
4. Tejani AH, Sullivan EK, Alexander SR, et al. Predictive factors for delayed graft function (DGF) and its impact on renal graft survival in children: a report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS). Pediatr Transplant 1999; 3:293-300.
5. Suri D, Meyer TW. Influence of donor factors on early function of graft kidneys. J Am Soc Nephrol 1999; 10:1317-1323.
6. Schwarz C, Regele H, Steininger R, et al. The contribution of adhesion molecule expression in donor kidney biopsies to early allograft dysfunction. Transplantation 2001; 71:1666-1670. In this study enhanced cell adhesion molecule expression in cadaveric compared with living donors contributed to the higher incidence of ARF.
7. Terasaki PI, Cecka JM, Gjertson DW, et al. High survival rates of kidney transplants from spousal and living unrelated donors. N Engl J Med 1995; 333:333-336.
8. Cecka JM. The UNOS Scientific Renal Transplant Registry - 2000. Clin Transplant 2000;1-18, Los Angeles, California, UOLA Immunogenetics Center.
9. Hazebroek EJ, Gommers D, Schreve MA, et al. Impact of intraoperative donor management on short-term renal function after laparoscopic donor nephrectomy. Ann Surg 2002; 236:127-132. This study reports that there is equal initial graft function in living donor kidneys among open and laparoscopically harvested organs.
10. Senel FM, Karakayali H, Moray G, et al. Delayed graft function: predictive factors and impact on outcome in living-related kidney transplantations. Renal Fail 1998; 20:589-595.
11. Boom H, Mallat MJ, de Fijter JW, et al. Delayed graft function influences renal function, but not survival. Kidney Int 2000; 58:859-866.
12. Hetzel GR, Klein B, Brause M, et al. Risk factors for delayed graft function after renal transplantation and their significance for long-term clinical outcome. Transplant Int 2002; 15:10-16. A recent study similar to Ref. 1, which confirmed the main donor factors for early allograft function. Unknown donor and recipient factors contributed to the development of ARF, because ARF of both kidneys from the same donor occurred only rarely.
13. Pfaff WW, Howard RJ, Patton PR, et al. Delayed graft function after renal transplantation. Transplantation 1998; 65:219-223.
14. de Fijter JW, Mallat MJ, Doxadis II, et al. Increased immunogenicity and cause of graft loss of old donor kidneys. J Am Soc Nephrol 2001; 12:1538-1546.
15. Melk A, Halloran PF. Cell senescence and its implications for nephrology. J Am Soc Nephrol 2001; 12:385-393. In this study advanced cell senescence in old donor or pre-damaged kidneys diminished cell regeneration after ischaemic injury.
16. Kyllonen LE, Salmela KT, Eklund BH, et al. Long-term results of 1047 cadaveric kidney transplantations with special emphasis on initial graft function and rejection. Transplant Int 2000; 13:122-128.
17. Schnuelle P, Lorenz D, Mueller A, et al. Donor catecholamine use reduces acute allograff rejection and improves graft survival after cadaveric renal transplantation. Kidney Int 1999; 56:738-746.
18. McLaren AJ, Jassem W, Gray DW, et al. Delayed graft function: risk factors and the relative effects of early function and acute rejection on long-term survival in cadaveric renal transplantation. Clin Transplant 1999; 13:266-272.
19. Matas AJ, Gillingham KJ, Humar A, et al. Immunologic and nonimmunologic factors: different risks for cadaver and living donor transplantation. Transplantation 2000; 69:54-58.
20. Kyllonen L, Salmela K. Transplantation of both kidneys from 408 donors; comparison of results. Transplant Int 2000; 13 (Suppl):95-S98.
21. Sanchez-Fructuoso AI, Prats D, Torrente J, et al. Renal transplantation from non-heart beating donors: a promising alternative to enlarge the donor pool. J Am Soc Nephrol 2000; 11:350-358.
22. Weber M, Dindo D, Demartines N, et al. Kidney transplantation from donors without a heartbeat. N Engl J Med 2002; 347:248-255. This study reported a high incidence of ARF in non-heart-beating donors.
23. Lechevallier E, Dussol B, Luccioni A, et al. Posttransplantation acute tubular necrosis: risk factors and implications for graft survival. Am J Kidney Dis 1998; 32:984-991.
24. Lehtonen SR, Taskinen EI, Isoniemi HM. Histopathological findings in renal allografts at time of transplantation and correlation with onset of graft function. Apmis 1999; 107:945-950.
25. Lehtonen SR, Taskinen EI, Isoniemi HM. Histological alterations in implant and one-year protocol biopsy specimens of renal allografts. Transplantation 2001; 72:1138-1144.
26. Karpinski J, Lajoie G, Cattran D, et al. Outcome of kidney transplantation from high-risk donors is determined by both structure and function. Transplantation 1999; 67:1162-1167.
27. Di Paolo S, Stallone G, Schena A, et al. Hypertension is an independent predictor of delayed graft function and worse renal function only in kidneys with chronic pathological lesions. Transplantation 2002; 73:623-627. In this study chronically pre-injured donor kidneys were prone to develop ARF.
28. Pratschke J, Wilhelm MJ, Laskowski I, et al. Influence of donor brain death on chronic rejection of renal transplants in rats. J Am Soc Nephrol 2001; 12:2474-2481.
29. Gasser M, Maria Waaga A, Kist-Van Holthe JE, et al. Normalization of brain death-induced injury to rat renal allografts by recombinant soluble p-selectin glycoprotein ligand. J Am Soc Nephrol 2002; 13:1937-1945. In this study brain death led to a systemic inflammatory status independent of the cause of death.
30. Tullius SG, Nieminen-Kelha M, Buelow R, et al. Inhibition of ischemia/reperfusion injury and chronic graft deterioration by a single-donor treatment with cobalt-protoporphyrin for the induction of heme oxygenase-1. Transplantation 2002; 74:591-598. This study showed the future role of heme oxygenase-1 induction in tubular cell protection against ischaemic injury.
31. Koo DD, Welsh KI, McLaren AJ, et al. Cadaver versus living donor kidneys: impact of donor factors on antigen induction before transplantation. Kidney Int 1999; 56:1551-1559.
32. Berger SP, Hunger M, Yard BA, et al. Dopamine induces the expression of heme oxygenase-1 by human endothelial cells in vitro [abstract]. Kidney Int 2000; 58:2314-2319.
33. Morimoto K, Ohta K, Yachie A, et al. Cytoprotective role of heme oxygenase (HO)-1 in human kidney with various renal diseases. Kidney Int 2001; 60:1858-1866.
34. Daemen MA, de Vries B, Buurman WA. Apoptosis and inflammation in renal reperfusion injury. Transplantation 2002; 73:1693-1700.
35. Schwarz C, Hauser P, Steininger R, et al. Failure of BCL-2 up-regulation in proximal tubular epithelial cells of donor kidney biopsy specimens is associated with apoptosis and delayed graft function. Lab Invest 2002; 82:941-948. In this study the failure of upregulation of anti-apoptotic genes led to enhanced apoptosis and ARF.
36. Cecka JM, Terasaki P, editors. Clinical Transplants 2000. Los Angeles, California: UCLA Immunogenetics Center; 2001.
37. Peherstorfer E, Mayer B, Boehm S, et al. Effects of microinjection of synthetic Bcl-2 domain peptides on apoptosis of renal tubular epithelial cells. Am J Physiol Renal Physiol 2002; 283:F190-F196.
38. Salahudeen AA, Jenkins JK, Huang H, et al. Overexpression of heme oxygenase protects renal tubular cells against cold storage injury: studies using hemin induction and HO-1 gene transfer. Transplantation 2001; 72:1498-1504.
39. Mister M, Noris M, Szymczuk J, et al. Propionyl-L-carnitine prevents renal function deterioration due to ischemia/reperfusion. Kidney Int 2002; 61:1064-1078.
40. Torras J, Herrero-Fresneda I, Lloberas N, et al. Promising effects of ischemic preconditioning in renal transplantation. Kidney Int 2002; 61:2218-2227.
41. Deng J, Kohda Y, Chiao H, et al. Interleukin-10 inhibits ischemic and cisplatin-induced acute renal injury. Kidney Int 2001; 60:2118-2128. IL-10 is a potent anti-inflammatory cytokine that reduced ischaemia-reperfusion injury in a mouse model.
42. Chen W, Bennett CF, Condon TP, et al. Methoxyethyl modification of phosphorothioate ICAM-1 antisense oligonucleotides improves prevention of ischemic/reperfusion injury. Transplant Proc 2001; 33:854.
43. Stepkowski SM, Chen W, Bennett CF, et al. Phosphorothioate/methoxyethyl-modified ICAM-1 antisense oligonucleotides improves prevention of ischemic/reperfusion injury. Transplant Proc 2001; 33:3705-3706.
44. Fuller TF, Sattler B, Binder L, et al. Reduction of severe ischemia/reperfusion injury in rat kidney grafts by a soluble P-selectin glycoprotein ligand. Transplantation 2001; 72:216-222.
45. Pratschke J, Kofla G, Wilhelm MJ, et al. Improvements in early behavior of rat kidney allografts after treatment of the brain-dead donor. Ann Surg 2001; 234:732-740. Donor treatment with steroids or soluble P-selectin glycoprotein ligand improved early allograft function in an animal model.
46. Da Silva M, Petruzzo P, Virieux S, et al. A primate model of renal ischemia-reperfusion injury for preclinical evaluation of the antileukocyte function associated antigen 1 monoclonal antibody odulimonab. J Urol 2001; 166:1915-1919.
47. Ventura CO, Coimbra TM, De Campos SB, et al. Mycophenolate mofetil attenuates renal ischemia/reperfusion injury. J Am Soc Nephrol 2002; 13:2524-2533.
48. Gonzalez N, Alvarez V, Pons H, et al. Mycophenolate mofetil aggravates postischemic acute renal failure in rats. Transplant Proc 2002; 34:43-44.
49. Yang CW, Ahn HJ, Han HJ, et al. Pharmacological preconditioning with low-dose cyclosporine or FKS06 reduces subsequent ischemia/reperfusion injury in rat kidney. Transplantation 2001; 72:1753-1759. Donor treatment with immunosuppressive substances such as tacrolimus or cyclosporine exhibited a protective effect on ischaemia-reperfusion injury in a rat model
50. Lieberthal W, Fuhro R, Andry CC, et al. Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells. Am J Physiol Renal Physiol 2001; 281:F693-F706. In this study sirolimus aggravated ischaemia-reperfusion injury by inhibiting the regeneration of tubular epithelial cells.
51. Faure JP, Hauet T, Han Z, et al. Polyethylene glycol reduces early and long-term cold ischemia-reperfusion and renal medulla injury. J Pharmacol Exp Ther 2002; 302:861-870.
52. Salmela K, Wramner L, Ekberg H, et al. A randomized multicenter trial of the anti-ICAM-1 monoclonal antibody (enlimomab) for the prevention of acute rejection and delayed onset of graft function in cadaveric renal transplantation: a report of the European Anti-ICAM-1 Renal Transplant Study Group. Transplantation 1999; 67:729-736.
53. Schnuelle P, Berger S, de Boer J, et al. Effects of catecholamine application to brain-dead donors on graft survival in solid organ transplantation. Transplantation 2001; 72:455-463. In this study it was found that catecholamine treatment of brain-dead donors may improve early and late allograft function.