Airway hyperresponsiveness in a large group of subjects with α1-antitrypsin deficiency: A cross-sectional controlled study

Journal of Internal Medicine

Volumn 253, Issue 3, 2003, Pages 351-358

  Malerba, M ^a   Radaeli, A ^a   Ceriani, L ^a   Tantucci, C ^a   Grassi, V ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

Author keywords

1 antitrypsin deficiency; Airway hyperresponsiveness; Lung function

Indexed keywords

ALPHA 1 ANTITRYPSIN; METHACHOLINE; PROTEINASE INHIBITOR; BRONCHOCONSTRICTING AGENT; CARBON MONOXIDE; DIAGNOSTIC AGENT; METHACHOLINE CHLORIDE;

ADULT; AIRWAY; ALPHA 1 ANTITRYPSIN DEFICIENCY; ARTICLE; BLOOD LEVEL; BRONCHUS; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; POPULATION RESEARCH; PREVALENCE; PRIORITY JOURNAL; PROVOCATION TEST; ADOLESCENT; AGED; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CROSS-SECTIONAL STUDY; INHALATION TEST; MIDDLE AGED; PHYSIOLOGY; VITAL CAPACITY;

ADOLESCENT; ADULT; AGED; ALPHA 1-ANTITRYPSIN DEFICIENCY; BRONCHIAL HYPERREACTIVITY; BRONCHIAL PROVOCATION TESTS; BRONCHOCONSTRICTOR AGENTS; CARBON MONOXIDE; CROSS-SECTIONAL STUDIES; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; MALE; METHACHOLINE CHLORIDE; MIDDLE AGED; VITAL CAPACITY;

EID: 0037335767     PISSN: 09546820     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2796.2003.01083.x     Document Type: Article

References (42)

1. Laurell CB, Eriksson S. The electrophoretic alpha 1 globulin pattern of serum in alphal-antitrypsin deficiency. Scand J Clin Lab Invest 1963; 15: 132-40.
2. Aboussuan LS, Stoller JK. New developments in alpha 1-antitrypsin deficiency. Am Respir Crit Care Med 1999; 20: 301-10.
3. 1-antitrypsin heterozygotes of phenotype PiMZ. Am J Respir Crit Care Med 2000; 161: 81-4.
4. Pina JS, Horan MP. Alpha 1-antitrypsin deficiency and asthma. The continuing search for the relationship. Postgrad Med 1997; 101: 153-68.
5. Barker AF, D'Silva RG, Buist AS. Lung function and alpha 1 AT deficiency. In: Crystal RG, ed. Alpha1-antitrypsin Deficiency: Biology, Pathogenesis, Clinical Manifestations, Therapy. New York: Marcel Dekker, 1996; 245-57.
6. Fallat RJ. Reactive airways disease and AAT deficiency. In: Crystal RG, ed. Alpha1-antitrypsin Deficiency: Biology, Pathogenesis, Clinical Manifestations, Therapy. New York: Marcel Dekker, 1996; 259-79.
7. Gaillard MC, Kilroe-Smith TA, Nogueira C et al. Alpha-1-protease inhibitor in bronchial asthma: phenotypes and biochemical characteristics. Am Rev Respir Dis 1992; 145: 1311-5.
8. Townley RG, Southard JG, Radford P, Hopp RJ, Bewtra AK, Ford L. Association of MS Pi phenotype with airway hyperresponsiveness. Chest 1990; 98: 594-9.
9. Stockley RA, Hill AT, Hill SL, Campbell EJ. Bronchial inflammation its relationship to colonizing microbial load and α1-antitrypsin deficiency. Chest 2000; 117: 291S.
10. Forteza R, Botvinnikova Y, Ahmed A. The interaction of alpha1-proteinase inhibitor and tissue kallikrein in controlling allergic ovine airway hyperresponsiveness. Am J Respir Crit Care Med 1996; 154: 36-42.
11. Blank CA, Brantly M. Clinical features and molecular characteristics of alpha 1 antitrypsin deficiency. Ann Allergy 1994; 72: 105-20.
12. Buist AS. Alpha 1-antitrypsin deficiency in lung and liver disease. Hosp Pract 1989; 24: 51-9.
13. Crystal RG. Alpha1-antitrypsin deficiency, emphysema, and liver disease. Genetic basis and strategies for therapy. J Clin Invest 1990; 85: 1343-52.
14. Cox D. Alpha 1 Antitrypsin Deficiency. In: Scriver C, Beaudet A, Sly W, Valle D eds. The Metabolic Basis of Inherited Disease, 6th edn. New York: McGrow-Hill, 1989; 2409-37.
15. Brantly ME, Paul LD, Miller BH, Falk RT, Wu M, Crystal RG. Clinical features and history of the destructive lung disease associated with alpha 1 antitrypsin deficiency of adults with pulmonary symptoms. Am Rev Respir Dis 1988; 138: 327-36.
16. Janus ED, Phillips NT, Carrel RW. Smoking, lung function, and alpha-1-1antitrypsin deficiency. Lancet 1985; 1: 152-4.
17. Silverman EK, Pierce JA, Province MA, Rao DC, Campbell EJ. Variability of pulmonary function in alpha 1 antitrypsin deficiency: clinical correlates. Anti Intern Med 1989; 111: 982-91.
18. Tobin MJ, Cook PJL, Hutchison DC, Alpha 1 antitrypsin deficiency: the clinical and physiological features of pulmonary emphysema in subjects for feature Pi type Z: a survey by the British thoracic association. Br J Dis Chest 1983; 77: 14-27.
19. Luisetti M, Massi G, Massobrio M et al (for the Gruppo I.D.A.). A national program for detection of α1-antitrypsin deficiency in Italy. Respir Med 1999; 93: 169-72.
20. Eriksson S. Studies in alpha-1-antitrypsin deficiency. Acta Med Scand 1965; 117: 421-8.
21. Massi G, Marano G, Patalano F, Auconi P. Silver-stained phenotyping alpha-1-antitrypsin in dried blood and serum specimens. Clin Chem 1984; 30: 1674-6.
22. Clausen JL, Coates AL, Quanjer PH. Measurement of lung Volumes in humane: review and recommendations from an ATS/ERS workshop. Eur Respir J 1997; 10: 1205-6.
23. Abboud RT, Sansores R. ATS recommendations for DLCO. Am J Respir Crit Care Med 1996; 154: 263.
24. Quanjer PH. Working Party on 'Standardisation of lung function tests'. Bull Eur Physiopathol Respir 1983; 19: 7-10.
25. American Thoracic Society. Guidelines for methacholine and exercise challenge testing. Am J Respir Crit Care Med 2000; 161: 309-29.
26. American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am Rev Respir Dis 1987; 136: 225-44.
27. NHLBI. Registry for Patients with Severe Deficiency of Alpha 1-Antitrypsin. Bethesda, MD: National Institutes of Health, November 1991.
28. Buist AS, Sexton GJ, Azzam AH, Adams BE. Pulmonary function in heterozygotes for alpha 1-antitrypsin deficiency: a case control study. Am Rev Respir Dis 1979; 120: 759-66.
29. Eden E, Mitchel D, Mehlman B et al. Atopy, asthma, and emphysema in patients with severe alpha1-antitrypsin deficiency. Am J Respir Crit Care Med 1997; 156: 68-74.
30. Larsson C. Natural history and life expectancy in severe alpha 1 antitrypsin, Pi. Z Acta Med Scand 1978; 105: 345-51.
31. Colp CR, Talavera W, Goldman D, Green J, Multz A, Lieberman J. Profile of bronchospastic disease in Puerto Rican patients in New York City. A possible relationship to alpha 1-antitrypsin variants. Arch Intern Med 1990; 150: 2349-54.
32. Eriksson S. Studies in alpha-1-antitrypsin deficiency. Acta Med 1965; 177 (Suppl. 432): 1-85, 421-8.
33. McElvaney NG, Stoller JK, Buist AS et al. Baseline characteristics of enrolees in the National Heart, Lung and Blood Institute registry of alpha1-antitrypsin deficiency. Chest 1997; 111: 394-403.
34. Sigsgaard T, Brandslund I, Omland O et al. S and Z alpha 1-antitrypsin alleles are risk factors for bronchial hyperresponsiveness in young farmers: an example of gene/enviroment interaction. Eur Respir J 2000; 16: 50-5.
35. Miravtlles M, Vilà S, Torrella M et al. Influence of deficient alpha 1-anti-trypsin phenotypes on characteristics and severity of asthma in adults. Resp Med 2002; 96: 186-92.
36. Stoller JK. Clinical features and natural history of severe alpha1-antitrypsin deficiency. Alpha Q Rev 1997; 1: 1-6.
37. Hill AT, Campbell EJ, Bayley DL, Hill SL, Stockley RA. Evidence for excessive bronchial inflammation during an acute exacerbation of COPD in patients with alpha-1-antitrypsin deficiency (PiZ). Am J Respir Crit Care Med 1999; 160: 1968-75.
38. Hill AT, Bayley DL, Stockley RA. The interrelationship of sputum inflammatory markers in patients with chronic bronchitis. Am J Respir Crit Care Med 1999; 160: 893-8.
39. Turino GM, Barker AF, Brantly ME et al. For the alpha 1-antitrypsin deficiency registry study group: clinical features of individual with PI*SZ phenotype of alpha1 antitrypsin deficiency. Am J Respir Crit Care Med 1996; 154: 1718-25.
40. Suzuki T, Wang W, Lin JT, Shirato K, Mitsuhashi H, Inoue H. Aerosolized human neutrophil elastase induces airway constriction and hyperresponsiveness with protection by intravenous pretreatment with half-length secretory leuko-protease inhibitor. Am J Respir Crit Care Med 1996; 153 (4 Part 1): 1405-11.
41. Fujimoto K, Kubo K, Shinozaki S et al. Neutrophil elastase inhibitor reduces asthmatic responses in allergic sheep. Respir Physiol 1995; 100: 91-100.
42. Matsumoto K, Aizawa H, Inoue H et al. Role of neutrophil elastase in ozone-induced airway responses in guinea-pigs. Eur Respir J 1999; 14: 1088-94.