Testicular and hematopoietic toxicity of 2-bromopropane, a substitute for ozone layer-depleting chlorofluorocarbons

Journal of Occupational Health

Volumn 39, Issue 1, 1997, Pages 57-63

  Ichihara, Gaku ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

2 bromopropane; Chlorofluorocarbon substitute; Hematopoietic toxicity; Sertoli cell only syndrome; Testicular toxicity

Indexed keywords

PROPANE; SOLVENT;

ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD CELL COUNT; BLOOD TOXICITY; BONE MARROW EXAMINATION; CONTROLLED STUDY; EPIDIDYMIS; EXPOSURE; GAS CHROMATOGRAPHY; HISTOPATHOLOGY; INHALATION; MALE; NONHUMAN; OLIGOSPERMIA; ORGAN WEIGHT; RAT; REPRODUCTIVE TOXICITY; SPERMATOZOON COUNT; TESTIS; TESTIS WEIGHT;

EID: 0031028308     PISSN: 13419145     EISSN: None     Source Type: Journal    
DOI: 10.1539/joh.39.57     Document Type: Article

References (16)

1. Industrial Health Research Institute, Korea Industrial Safety Corporation. Final report of epidemiological survey on Yangsan LG Electronics. 1995 (in Korean).
2. Liublina E, Rabotnikova L. Comparative evaluation of acute toxcity of certain brominated hydrocarbons. Gigiena Truda i Professionalnye Zabolevaniia, 1974 Apr 18(4): 55-7(in Russian).
3. Ichihara G, Asaeda N, Kumazawa T, et al. Testicular toxicity of 2-bromopropane. J Occup Health 1996; 38:205-206.
4. Kim H, Chung Y, Yi K, Kirn J, Yu I. LC50 of 2bromopropane. Ind Health 1996; 34: 403-407.
5. Takeuchi Y, Huang J, Shibata E, Hisanaga N, Ono Y. A trial to automatize an organic solvent exposure system for small animals. Jpn J Ind Health 1989; 31 : 722 (in Japanese).
6. Huang J, Kato K, Shibata E, Hisanaga N, Ono Y, Takeuchi Y. Effects of subacute toluene exposure on neuronal and glial marker proteins in rat brain. Toxicol 1990; 61: 109-117.
7. Wyrobek A, Bruce W. Chemical induction of sperm abnormalities in mice. Proc Natl Acad Sei USA 1975; 72:4425-4429.
8. Eyden B, Maisin J. Observations on the structure and levels of expression of murine spermatozoan abnormalities with special reference to tail deformations. Arch Anat Microsc 1978; 67: 19-30.
9. Flores M, Fawcett D. Ultrastructure effects of antispermatogenic compound WIN 18446 (bis dichloroacetyl diamine). Anat Rec 1972; 172: 310.
10. De Martino C, Stefanini M, Agrestini A, Cocchia D, Morrelli M, Scorza Barcellona P. Antispermatogenic activity of 1-p chlorobenzyl-1 H indazol-3-carboxylic acid (AF 1321/TS) in rats. III. A light and electron microscopic study after single oral doses. Exp Mol Pathol 1975; 23: 321-356.
11. Hoffer A, Carlton B, Brunengraber H. Ultrastructure and intercellular vacuolization of isolated perfused and control rat testes. J Androl 1983; 4: 361-370.
12. Chapin R, Morgan K, Bus J. The morphogenesis of testicular degeneration induced in rats by orally administered 2,5-hexanedione. Exp Mol Pathol 1983; 38: 149-169.
13. Creasy D, Beech L, Gray T, Butler W. An ultrastructural study of ethylene glycol monomethyl ether-induced spermatocyte injury in the rat. Exp Mol Pathol 1986; 45: 311-322.
14. Anderson R, Berryman S, Phillips J, Feathergill K, Zaneveld L, Russell L. Biochemical and structural evidence for ethanol-induced impairment of testicular development: apparent lack of Leydig cell involvement. Toxicol Appl Pharmacol 1989; 100: 62-85.
15. Creasy D, Ford GR, Gray TJ. The morphogenesis of cyclohexylamine-induced testicular atrophy in the rat: in vivo and in vitro studies. Exp Mol Pathol 1990; 52(2): 155-169.
16. Kaczmarczyk J, Paul M. Reproductive health hazards in the workplace: guidelines for policy development and implementation. Int J Occup Environ Health 1996; 2: 48-58.