Tumour necrosis factor-alpha promoter gene polymorphism at -308 (genotype AA) in Chinese subjects with Type 2 diabetes [1]

Diabetic Medicine

Volumn 20, Issue 2, 2003, Pages 167-168

  Ko, G T C ^a   Lee, S C ^b   Pu, Y B ^b   Ng, M C Y ^b   So, W Y ^b   Thomas, N ^b   Chan, W B ^b   Cockram, C S ^b   Chan, J C N ^b  

^a ALICE HO MIU LING NETHERSOLE HOSPITAL   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR NECROSIS FACTOR ALPHA;

ADULT; CHINESE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENOTYPE; HUMAN; INSULIN RESISTANCE; LETTER; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PROMOTER REGION;

ADOLESCENT; ADULT; CHINA; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037332232     PISSN: 07423071     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1464-5491.2003.00829_1.x     Document Type: Letter

References (5)

1. Wilson AG, di Giovine FS, Blakemore AIF, Duff GW. Single base polymorphism in the human tumor necrosis factor alpha (TNF-α) gene detectable by Nco I restriction of PCR product. Hum Mol Genet 1992; 1: 353.
2. Hamann A, Mantzoros C, Vidal-Puig A, Flier JS. Genetic variability in the TNF-alpha promoter is not associated with type II diabetes mellitus. Biochem Biophys Res Commun 1995; 211: 833-839.
3. Deng GY, Maclaren NK, Huang HS, Zhang LP, She JX. No primary association between the 308 polymorphism in the tumor necrosis factor alpha promoter region and insulin-dependent diabetes mellitus. Hum Immunol 1996; 45: 137-142.
4. Lee SC, Pu YB, Thomas GN, Lee ZS, Tomlinson B, Cockram CS et al. Tumor necrosis factor alpha gene G-308A polymorphism in the metabolic syndrome. Metabolism 2000; 49: 1021-1024.
5. Dalziel B, Gosby AK, Richman RM, Bryson JM, Caterson ID. Association of the TNF-alpha-308 G/A promoter polymorphism with insulin resistance in obesity. Obes Res 2002; 10: 401-407.