Calmodulin inhibitors from Leucophyllum ambiguum

Journal of Natural Products

Volumn 66, Issue 2, 2003, Pages 221-224

  Rojas, Susana ^a   Acevedo, Laura ^a   Macías, Martha ^a   Toscano, Rubén A ^a   Bye, Robert ^a   Timmermann, Barbara ^b   Mata, Rachel ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2' METHOXY 4'' HYDROXYDEMETHOXYKOBUSIN; 2' METHOXYKOBUSIN; 2',2'' DIMETHOXYSESAMIN; APIGENIN; APIGETRIN; CALMODULIN; CALMODULIN INHIBITOR; CHLORPROMAZINE; CINNAMIC ACID; CYCLIC AMP PHOSPHODIESTERASE; KOBUSIN; LIGNAN; PLANT EXTRACT; UNCLASSIFIED DRUG;

ARTICLE; CATTLE; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; DRUG ISOLATION; HERBAL MEDICINE; INFRARED SPECTROSCOPY; LEUCOPHYLLUM AMBIGUUM; MEDICINAL PLANT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYACRYLAMIDE GEL ELECTROPHORESIS; X RAY DIFFRACTION;

ANIMALS; APIGENIN; BRAIN; CALMODULIN; CATTLE; CINNAMATES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLAVONOIDS; GLYCOPROTEINS; LIGNANS; MEXICO; MOLECULAR STRUCTURE; PLANTS, MEDICINAL; SCROPHULARIACEAE; STEREOISOMERISM;

BOS TAURUS; BOVINAE; LEUCOPHYLLUM;

EID: 0037331896     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np020346i     Document Type: Article

References (20)

1. This work represents part of the Ph.D. thesis of S. Rojas.
2. Argueta, A. Atlas de las Plantas de la Medicina Tradicional Mexicana; Instituto Nacional Indigenista: México, 1994; Vol. III, p 521.
3. Hook, S.; Means, A. R. Annu. Rev. Pharmacol. Toxicol. 2001, 41, 471-505.
4. Iida, T.; Nakano, M.; Ito, K. Phytochemistry 1982, 21, 673-675.
5. Jaensch, M.; Jakupovic, J.; King, R.; Robinson, H. Phytochemistry 1989, 28, 3497-3501.
6. Miyazawa, M.; Okuno, Y.; Nakamura, S.; Kameoka, H. J. Agric. Food Chem. 1998, 46, 904-910.
7. Harborne, J., Mabry, T., Mabry, H., Eds. The Flavonoids; Academic Press: New York, 1975; pp 19, 84.
8. Pelter, A.; Ward, R.; Rao, V.; Sastry, K. Tetrahedron 1976, 32, 2783-2788.
9. Biavatti, M.; Vieira, P.; da Silva, F.; Fernández, J.; Degani, A.; Cass, Q.; Schefer, A.; Ferreira, A. Phytochem. Anal. 2001, 12, 64-68.
10. Rahman, M.; Dewick, P.; Jackson, D.; Lucas, J. Phytochemistry 1990, 29, 1971-1980.
11. Agrawal, P.; Takhur, R. Magn. Reson. Chem. 1985, 23, 389-418.
12. Hofer, O.; Schölm, R. Tetrahedron 1981, 37, 1181-1186.
13. Latip, J.; Hartley, T.; Waterman, P. G. Phytochemistry 1999, 51, 107-110.
14. Greger, H.; Hofer, O. Tetrahedron 1980, 36, 3551-3558.
15. Macías, M.; Ulloa, M.; Gamboa A.; Mata, R. J. Nat. Prod. 2000, 63, 757-761.
16. Wang, J.; Sharma, R. K. In Advances in Cyclic Nucleotide Research; Broker, G., Greengard P., Robison, G. A., Eds.; Raven Press: New York, 1979; pp 187-198.
17. Sumner, J. B. Science 1944, 100, 413-415.
18. Crystallographic data for the structure reported in this paper have been deposited with the Cambridge Crystallograpic Data Centre. Copies of the data can be obtained, free of charge, on application to the Director, CCDC, 12 Union Road, Cambridge CB2 1EZ, UK [fax: +44 (0)1223-336033 or e-mail: deposit@ccdc.cam.ac.uk].
19. Altomare, A.; Cascarano, G.; Giacovazzo, C.; Guagliardi, A.; Burla, M. C.; Polidori, G.; Camalli, M. J. Appl. Crystallogr. 1994, 27, 435.
20. Sheldrick, G. M. SHELXTL97: Program for Refinement of Crystal Structures; University of Göttingen: Germany, 1997.