Discovery of orally bioavailable NK1 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 3, 2003, Pages 437-442

  Genicot, C ^a   Christophe, B ^a   Collart, P ^a   Gillard, M ^a   Goossens, L ^b   Henichart J P ^b   Lassoie, M A ^a   Moureau, F ^a   Neuwels, M ^a   Nicolas, J M ^a   Pasau, P ^a   Quere L ^a   Ryckmans, T ^a   Stiernet, F ^a   Taverne, T ^b   Van Keulen, B J ^a  

^a UCB PHARMA   (Belgium)

^b Faculté des Sciences Pharmaceutiques et Biologiques Université de Lille   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 BENZHYDRYL 3 (2 METHOXYBENZYLAMINO) 1 AZABICYCLO[2.2.2]OCTANE; 3 (2 METHOXY 5 TRIFLUOROMETHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; 3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; 3 [3,5 BIS(TRIFLUOROMETHYL)BENZYLOXY] 2 PHENYLPIPERIDINE; APREPITANT; CALCIUM CHANNEL L TYPE; PIPERAZINE DERIVATIVE;

ARTICLE; BINDING AFFINITY; DRUG BIOAVAILABILITY; DRUG SCREENING; MOLECULAR INTERACTION;

ACYLATION; ALKYLATION; ANIMALS; BIOLOGICAL AVAILABILITY; CARBOXYLIC ACIDS; CHEMISTRY, PHYSICAL; CHO CELLS; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; GUINEA PIGS; HUMANS; INDICATORS AND REAGENTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NITROGEN; PIPERAZINES; PULMONARY EDEMA; RECEPTORS, NEUROKININ-1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037331022     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00956-3     Document Type: Article

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