Discovery, SAR, synthesis, pharmacokinetic and biochemical characterization of A-192411: A novel fungicidal lipopeptide-(I)

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 3, 2003, Pages 489-493

  Wang, Weibo ^a   Li, Qun ^a   Hasvold, Lisa ^a   Steiner, Beth ^a   Dickman, Daniel A ^a   Ding, Hong ^a   Clairborne, Akyio ^a   Chen, Hui Ju ^a   Frost, David ^a   Goldman, Robert C ^a   Marsh, Kennan ^a   Hui, Yu Hua ^a   Cox, Brian ^a   Nilius, Angela ^a   Balli, Darlene ^a   Lartey, Paul ^a   Plattner, Jacob J ^a   Bennani, Youssef L ^a,b  

^a ABBOTT LABORATORIES   (United States)

^b ATHERSYS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

A 192411; ANTIFUNGAL AGENT; LIPOPEPTIDE;

ANIMAL CELL; ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG POTENCY; DRUG SAFETY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MEAN ARTERIAL PRESSURE; MYCOSIS; NONHUMAN; RAT; SIDE EFFECT; STRUCTURE ACTIVITY RELATION; YEAST;

ANIMALS; ANTIFUNGAL AGENTS; AREA UNDER CURVE; CANDIDA; CANDIDIASIS; CHEMISTRY, PHYSICAL; DOGS; DRUG DESIGN; FUNGI; GLUCANS; HAPLORHINI; MICE; MICROBIAL SENSITIVITY TESTS; OLIGOPEPTIDES; RATS; RNA, FUNGAL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037330590     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00978-2     Document Type: Article

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