Total synthesis and antifungal evaluation of cyclic aminohexapeptides

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 7, 2000, Pages 1677-1696

  Klein, Larry L ^a   Li, Leping ^b   Chen, Hui Ju ^a   Curty, Cynthia B ^a   Degoey, David A ^a   Grampovnik, David J ^a   Leone, Christina L ^a   Thomas, Sheela A ^a   Yeung, Clinton M ^a   Funk, Kenneth W ^a   Kishore, Vimal ^a   Lundell, Edwin O ^a   Wodka, Dariusz ^a   Meulbroek, Jon A ^a   Alder, Jeffrey D ^c   Nilius, Angela M ^a   Lartey, Paul A ^d   Plattner, Jacob J ^e  

^a ABBOTT LABORATORIES   (United States)

^b AMGEN INC   (United States)

^c Scriptgen Pharmaceuticals   (United States)

^d PFIZER INC   (United States)

^e NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ANTIFUNGAL AGENT; HEXAPEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SOLUBILITY; DRUG SYNTHESIS; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOUSE; MYCOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ACUTE DISEASE; AMINES; AMPHOTERICIN B; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; CANDIDA; CANDIDIASIS, VULVOVAGINAL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FUNGAL PROTEINS; MICE; MICROBIAL SENSITIVITY TESTS; PEPTIDES; PEPTIDES, CYCLIC; PROLINE; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; YEASTS;

EID: 0033948005     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(00)00097-3     Document Type: Article

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