Splenic marginal zone atrophy and progressive CD8+ T-cell lymphocytosis in HIV infection: A study of adult post-mortem spleens from Côte d'Ivoire

Histopathology

Volumn 42, Issue 2, 2003, Pages 173-185

  Wilkins, B S ^a,d   Davis, Z ^a   Lucas, S B ^b   Delsol, G ^c   Jones, D B ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c CHU PURPAN   (France)

^d ROYAL VICTORIA INFIRMARY   (United Kingdom)

Author keywords

AIDS; HIV; Human spleen; Immunohistochemistry; Red pulp; White pulp

Indexed keywords

CD45 ANTIGEN; CD8 ANTIGEN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADOLESCENT; ADULT; AFRICA; ARTICLE; ATROPHY; AUTOPSY; B LYMPHOCYTE; BACTERIAL INFECTION; BACTERIUM; CONTROLLED STUDY; COTE D'IVOIRE; DISEASE COURSE; DISEASE PREDISPOSITION; ETHNOLOGY; HELPER CELL; HISTOPATHOLOGY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; LYMPHOCYTOSIS; LYMPHOID TISSUE; MAJOR CLINICAL STUDY; NONHUMAN; PRIORITY JOURNAL; SPLEEN; UNITED KINGDOM;

ADOLESCENT; ADULT; ANTIGENS, CD45; ATROPHY; CD4-CD8 RATIO; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; COTE D'IVOIRE; HIV INFECTIONS; HUMANS; IMMUNOENZYME TECHNIQUES; LYMPHOCYTOSIS; MIDDLE AGED; ORGAN SIZE; SPLEEN; T-LYMPHOCYTE SUBSETS;

BACTERIA (MICROORGANISMS); HUMAN IMMUNODEFICIENCY VIRUS; RNA VIRUSES;

EID: 0037329146     PISSN: 03090167     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2559.2003.01569.x     Document Type: Article

References (37)

1. Ewing EP Jr, Chandler FW, Spira TJ, Brynes RK, Chan WC. Primary lymph node pathology in AIDS and AIDS-related lymphadenopathy. Arch. Pathol. Lab. Med. 1985: 109; 977-981.
2. Pileri S, Rivano MT, Raise E et al. The value of lymph node biopsy in patients with the acquired immunodeficiency syndrome (AIDS) and the AIDS-related complex (ARC): a morphological and immunohistochemical study of 90 cases. Histopathology 1986: 10; 1107-1129.
3. Piris MA, Rivas C, Morente M, Rubio C, Martin C, Olivia H. Persistent and generalized lymphadenopathy, a lesion of follicular dendritic cells? Am. J. Clin. Pathol. 1987: 87; 716-724.
4. Klatt E, Meyer P. Pathology of the spleen in the acquired immunodeficiency syndrome. Arch. Pathol. Lab. Med. 1987: 111; 1050-1053.
5. Falk S, Müller H, Stutte H-J. The spleen in acquired immunodeficiency syndrome (AIDS). Pathol. Res. Prac. 1988: 183; 425-433.
6. Mathew A, Raviglione MC, Niranjan U, Sabatini MT, Distenfeld A. Splenectomy in patients with AIDS. Am. J. Hematol. 1989: 32; 184-189.
7. Grotto H, Costa F. Hyposplenism in AIDS, AIDS 1991: 5; 1538-1540.
8. Pedro-Botet J, Maristany M, Miralles R., López-Colomés J. Rubiés-Prat J. Splenic tuberculosis in patients with AIDS. Rev. Infect. Dis. 1991: 13; 1069-1071.
9. Quijano G, Siminovich M, Drut R. Histopathologic findings in the lymphoid and reticulo-endothelial system in pediatric HIV infection: a post-mortem study. Pediatric Pathol. Lab. Med. 1997: 17; 845-856.
10. van Krieken JHJM, te Velde J. Normal histology of the human spleen. Am. J. Surg. Pathol. 1988: 12; 777-785.
11. Bruyn GAW, Zegers BJM, van Furth R. Mechanisms of host defence against infection with Streptococcus pneumoniae. Clin. Infect. Dis. 1992: 14; 251-262.
12. Kopp WC. The immune functions of the spleen. In Bowdler AJ ed. The spleen - structure, function and clinical significance. London: Chapman & Hall, 1990; Chapter 5.
13. van Krieken JHJM, te Velde J. Immunohistology of the human spleen: an inventory of the localization of lymphocyte subpopulations. Histopathology 1986: 10; 285-294.
14. Timens W, Poppema S. Lymphocyte compartments in human spleen; an immunohistologic study in normal spleens and noninvolved spleens in Hodgkin's disease. Am. J. Pathol, 1985: 120; 443-454.
15. Lucas SB, Hounnou A, Peacock C et al. The mortality and pathology of HIV infection in a West African city. AIDS 1993: 7; 1569-1579.
16. Domoua K, N'Dhatz M, Coulibaly G et al. Autopsy findings in 70 AIDS patients who died in a department of pneumology in Ivory Coast: impact of tuberculosis. Med. Trop. 1995: 55; 252-254. (French; English abstract).
17. Lucas S, Peacock C, Hounnou A et al. Disease in children infected with HIV in Abidjan, Côte d'Ivoire, Br. Med. J. 1996: 312; 335-338.
18. Wilkins BS, Jones DB, Treasure J, Delsol G. Alpha smooth muscle actin expression and white pulp compartmentalisation in normal and reactive human spleen. J. Anat. 1995: 187; 206.
19. Centers for Disease Control and Prevention. Revision of the CDC surveillance case definition for AIDS. MMWR 1987: 36; 15S.
20. Cuevas EC, Bateman AC. Wilkins BS et al. Microwave antigen retrieval in immunocytochemistry. A study of 80 antibodies. J. Clin. Pathol. 1994: 47; 448-452.
21. Wilkins BS, Westwick R, Green A, Jones DB. Alpha-smooth muscle actin is expressed by a perifollicular cell network in normal and reactive human spleens. J. Pathol. 1995: 176 (Suppl.); 37A.
22. van Krieken JHJM, te Velde J, Hermans J, Cornelisse CJ, Welvaart C, Ferrari M. The amount of white pulp in the spleen; a morphological study done in methacrylate-embedded splenectomy specimens. Histopathology 1983: 7; 767-782.
23. Farhi DC, Ashfaq R. Splenic pathology after traumatic injury. Am. J. Clin. Pathol. 1996: 105; 474-478.
24. Pinching AJ. Bacteraemias in HIV-positive patients. Lancet 1990: 336; 877.
25. Janoff EN, Breiman RF, Daley CL, Hopewell PC. Pneumococcal disease during HIV infection. Epidemiologic, clinical and immunologic perspectives. Ann. Intern. Med. 1992: 117; 314-324.
26. Vugia DJ, Kiehlbauch JA, Yeboue K et al. Pathogens and predictors of fatal septicemia associated with human immunodeficiency virus in Ivory Coast, West Africa. J. Infect. Dis. 1993: 168; 564-570.
27. Marti M, Feliu E, Campo E et al. Comparative study of spleen pathology in drug abusers with thrombocytopenia related to human immunodeficiency virus infection and in patients with idiopathic thrombocytopenic purpura. Am. J. Clin. Pathol. 1993: 100; 633-642.
28. Dominguez A, Gamallo G, Garcia R, Lopez-Pastor A, Peña J, Vazquez J. Pathophysiology of HIV related thrombocytopenia: an analysis of 41 patients. J. Clin. Pathol. 1994: 47; 999-1003.
29. Beverley PCL. Human T-cell memory. Current Topics Microbiol. Immunol. 1990: 159; 111-122.
30. Cheynier R, Henrichwark S, Hadida F et al. HIV and T cell expansion in splenic white pulps is accompanied by infiltration of HIV-specific cytotoxic T lymphocytes. Cell 1994: 78; 373-387.
31. Tenner-Racz K, Racz P, Thomé C et al. Cytotoxic effector cell granules recognized by the monoclonal antibody TIA-1 are present in CD8+ve lymphocytes in lymph nodes of human immunodeficiency virus-1-infected patients. Am. J. Pathol. 1993: 142; 1750-1758.
32. Sunila I, Vaccarezza M, Pantaleo G, Fauci A, Orenstein J. Activated cytotoxic lymphocytes in lymph nodes from human immunodeficiency virus (HIV) 1-infected patients: a light and electronmicroscopic study. Histopathology 1997: 30; 31-40.
33. Itescu S, Brancato L, Buxbaum J et al. A diffuse infiltrative CD8 lymphocytosis syndrome in human immunodeficiency virus (HIV) infection: a host immune response associated with HLA-DRS. Ann. Intern. Med. 1990: 112; 3-10.
34. Oksenhendler E, Autran B, Gorochov G, d'Agay M, Seligmann M, Clauvel J-P. CD8 lymphocytosis and pseudotumoral splenomegaly in HIV infection. Lancet 1992: 340; 207-208.
35. Lucas S, Diomande M, Hounnou A et al. HIV-associated lymphoma in Africa: an autopsy study from Cote d'Ivoire. Int. J. Cancer 1994: 59; 20-24.
36. Tsoukas CM, Bernard NF, Abrahamowicz M et al. Effect of splenectomy on slowing human immunodeficiency virus disease progression. Arch. Surg. 1998: 133; 25-31.
37. Al Saati T, Caspar S, Brousset P et al. Production of anti-B monoclonal antibodies (DBB.42, DBA.44, DNA.7 and DND.53) reactive on paraffin-embedded tissues with a new B-lymphoma cell line grafted into athymic nude mice. Blood 1989: 74; 2474-2485.