Activated cytotoxic lymphocytes in lymph nodes from human immunodeficiency virus (HIV) 1-infected patients: A light and electronmicroscopic study

Histopathology

Volumn 30, Issue 1, 1997, Pages 31-40

  Sunila, I ^a   Vaccarezza, M ^b   Pantaleo, G ^b   Fauci, A S ^b   Orenstein, J M ^a  

^a GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

cytotoxic lymphocytes; human immunodeficiency virus (HIV) type 1; lymph nodes; perforin; TIA 1

Indexed keywords

PERFORIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CYTOTOXIC LYMPHOCYTE; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOELECTRON MICROSCOPY; IMMUNOGOLD STAINING; IMMUNOHISTOCHEMISTRY; LYMPH NODE; MALE; PRIORITY JOURNAL;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0031022835     PISSN: 03090167     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2559.1996.d01-559.x     Document Type: Article

References (32)

1. Ewing EP, Chandler FW, Spira TJ, Brynes RK, Chan WC. Primary lymph node pathology in AIDS and AIDS-related lymphadenopathy. Arch. Pathol. Lab. Med. 1985: 109; 977-981.
2. Pileri S, Rivano MT, Raise E et al. The value of lymph node biopsy in patients with the acquired immunodeficiency syndrome (AIDS) and the AIDS-related complex (ARC): a morphological and immunohistochemical study of 90 cases. Histopathol. 1986: 10; 1107-1129.
3. Racz P, Tenner-Racz K, Kahl C, Feller AC, Kern P, Dietrich M. Spectrum of morphologic changes of lymph nodes from patients with AIDS or AIDS-related complexes. Prog. Allergy 1986: 37; 81-181.
4. Armstrong JA, Horne R. Follicular dendritic cells and virus-like particles in AIDS-related lymphadenopathy. Lancet 1984: 2; 370-372.
5. Le Tourneau A, Audouin J, Diebold J, Marche C, Tricottet V, Reynes M. LAV-like viral particles in lymph node germinal centers in patients with the persistent lymphadenopathy syndrome and the acquired immunodeficiency syndrome-related complex: an ultrastructural study of 30 cases. Hum. Pathol. 1986: 17; 1047-1053.
6. Piris MA, Rivas C, Morente M, Rubio C, Martin C, Olivia H. Persistent and generalized lymphadenopathy: a lesion of follicular dendritic cells? An immunohistologic and ultrastructural study. Am. J. Clin. Pathol. 1987: 87; 716-724.
7. Joling P, Bakker LJ, Van Strijp JAG et al. Binding of human immunodeficiency virus type-1 to follicular dendritic cells in vitro is complement dependent. J. Immunol. 1993: 150; 1065-1073.
8. Schuurman H-J, Krone WJA, Broekhuizen R, Goudsmit J. Expression of RNA and antigens of human immunodeficiency virus type-1 (HIV-1) in lymph nodes from HIV-1 infected individuals. Am. J. Pathol. 1988: 113; 516-524.
9. Shibata D, Brynes RK, Nathwani B, Kwok S, Sninsky J, Arnheim N. Human immunodeficiency viral DNA is readily found in lymph node biopsies from seropositive individuals: analysis of fixed tissue using the polymerase chain reaction. Am. J. Pathol. 1989: 135; 697-702.
10. Parmentier HK, Van Wichen D, Sie-Go DMDS, Goudsmit J, Borleffs JCC, Schuurman H-J. HIV-1 infection and virus production in follicular dendritic cells in lymph nodes. A case report, with analysis of isolated follicular dendritic cells. Am. J. Pathol. 1990: 137; 247-251.
11. Spiegel H, Herbst H, Niedobitek G, Foss H-D, Stein H. Follicular dendritic cells are a major reservoir for human immunodeficiency virus type 1 in lymphoid tissues facilitating infection of CD4+ T-helper cells. Am. J. Pathol. 1992: 140; 15-22.
12. Burke AP, Benson W, Ribas JL et al. Postmortem localization of HIV-1 RNA by in situ hybridization in lymphoid tissues of intravenous drug addicts who died unexpectedly. Am. J. Pathol. 1993: 142; 1701-1713.
13. Pantaleo G, Graziosi C, Demarest JF et al. HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 1993: 362; 355-358.
14. Tenner-Racz K, Racz P, Bofill M et al. HTLV-III/LAV viral antigens in lymph nodes of homosexual men with persistent generalized lymphadenopathy and AIDS. Am. J. Pathol. 1986: 123; 9-15.
15. Cameron PU, Dawkins RL, Armstrong JA, Bonifacio E. Western blot profiles, lymph node ultrastructure and viral expression in HIV-infected patients: a correlative study. Clin. Exp. Immunol. 1987: 68; 465-478.
16. Said JW, Shintaku IP, Teitelbaum A, Chien K, Sassoon AF. Distribution of T-cell phenotypic subsets and surface immunoglobulin-bearing lymphocytes in lymph nodes from male homosexuals with persistent generalized adenopathy: an immunohistochemical and ultrastructural study. Hum. Pathol. 1984: 15; 785-790.
17. Baroni CD, Pezzella F, Stoppacciaro A et al. Systemic lymphadenopathy (LAS) in intravenous drug abusers. Histology, immunohistochemistry and electron microscopy: pathogenic correlations. Histopathol. 1985: 9; 1275-1293.
18. Diebold J, Marche C, Audouin J et al. Lymph node modification in patients with the acquired immunodeficiency syndrome (AIDS) or with AIDS related complex (ARC). A histological, immunohistopathological and ultrastructural study of 45 cases. Pathol. Res. Prac. 1985: 180; 590-611.
19. Janossy G, Pinching AJ, Bofill M et al. An immunohistological approach to persistent lymphadenopathy and its relevance to AIDS. Clin. Exp. Immunol. 1985: 59; 257-266.
20. Porwit A, Bottinger B, Pallesen G, Bodner A, Biberfeld P. Follicular involution in HIV lymphadenopathy. APMIS 1989: 97; 153-165.
21. Laman JD, Claassen E, Van Rooijen N, Boersma WJA. Immune complexes on follicular dendritic cells as a target for cytolytic cells in AIDS. AIDS 1989: 3; 543-544.
22. Devergne O, Peuchmaur M, Crevon MC et al. Activation of cytotoxic cells in hyperplastic lymph nodes from HIV-infected patients. AIDS 1991: 5; 1071-1079.
23. Parmentier HK, Van Wichen DF, Peters PJ, Tchopp J, De Weger RA, Schuurman H-J. No histological evidence for cytotoxic T cells in destruction of lymph-node follicle centers after HIV infection. AIDS 1991: 5; 778-780.
24. Parmentier HK, Schuurman H-J. Cytotoxic CD8+ T cells in lymph node follicle centres after HIV-1 infection? A reply. AIDS 1992: 6; 334-335.
25. Tenner-Racz K, Racz P, Thome C et al. Cytotoxic effector cell granules recognized by the monoclonal antibody TIA-1 are present in CD8+ lymphocytes in lymph nodes of human immunodeficiency virus-1-infected patients. Am. J. Pathol. 1993: 142; 1750-1758.
26. Peters PJ, Borst J, Oorschot V et al. Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes. J. Exp. Med. 1991: 173; 1099-1109.
27. Peters PJ, Geuze HJ, Van der Donk HA et al. Molecules relevant for T cell-target cell interaction are present in cytolytic granules of human T lymphocytes. Eur. J. Immunol. 1989: 19; 1469-1475.
28. Kägi D, Vignaux F, Ledermann B et al. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science 1994: 265; 528-530.
29. Lichtenheld MG, Olsen KJ, Lu P et al. Structure and function of human perforin. Nature 1988: 335; 448-451.
30. Anderson P, Nagler-Anderson C, O'Brien C et al. A monoclonal antibody reactive with a 15-kDa cytoplasmic granule-associated protein defines a subpopulation of CD8+ T lymphocytes. J. Immun. 1990: 144; 574-582.
31. Pantaleo G, De Maria A, Koenig S et al. CD8+ T lymphocytes of patients with AIDS maintain normal broad cytolytic function despite the loss of human immunodeficiency virus-specific cytotoxicity. Proc. Natl. Acad. Sci. USA 1990: 87; 4818-4822.
32. + cell levels. J. Infect. Dis. 1994: 170; 775-781.