Spindle epithelial tumor with thymus-like differentiation of the thyroid: A case report with pathological and molecular genetics study

Human Pathology

Volumn 34, Issue 2, 2003, Pages 190-193

  Xu, Bing ^a   Hirokawa, Mitsuyoshi ^b   Yoshimoto, Katsuhiko ^b   Miki, Hitoshi ^b   Takahashi, Masanori ^b   Kuma, Seiji ^b   Sano, Toshiaki ^b  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b NONE

Author keywords

Ras oncogene; Spindle epithelial tumor with thymus like differentiation; Thyroid

Indexed keywords

ALPHA ACTIN; CALCITONIN; CARCINOEMBRYONIC ANTIGEN; CYTOKERATIN; DNA; EPITHELIAL MEMBRANE ANTIGEN; PROTEIN P53; THYROGLOBULIN; VIMENTIN;

ALLELE; ARTICLE; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIFFERENTIATION; ECHOGRAPHY; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; ONCOGENE K RAS; PHYSICAL EXAMINATION; POLYMERASE CHAIN REACTION; SPINDLE CELL; THYMUS; THYROID FUNCTION TEST; THYROID TUMOR; TUMOR SUPPRESSOR GENE;

EID: 0037328037     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1053/hupa.2003.29     Document Type: Article

References (14)

1. Chan JK, Rosai J: Tumors of the neck showing thymic or related branchial pouch differentiation: A unifying concept. HUM PATHOL 22:349-367, 1991
2. Harach HR, Saravia Day E, Franssila KO: Thyroid spindle-cell tumor with mucous cysts. An intrathyroid thymoma? Am J Surg Pathol 9:525-530, 1985
3. Murao T, Nakanishi M, Toda K, et al: Malignant teratoma of the thyroid gland in an adolescent female. Acta Pathol Jpn 29:109-117, 1979
4. Kimler SC, Muth WF: Primary malignant teratoma of the thyroid: Case report and literature review of cervical teratomas in adults. Cancer 42:311-317, 1978
5. Weigensberg C, Dalsley H, Asa SL, et al: Thyroid thymoma in childhood. Endocr Pathol 1:123-127, 1990
6. Cheuk W, Jacobson AA, Chan JK: Spindle epithelial tumor with thymus-like differentiation (SETTLE): A distinctive malignant thyroid neoplasm with significant metastatic potential. Mod Pathol 13:1150-1155, 2000
7. Suarez HG: Genetic alterations in human epithelial thyroid tumours. Clin Endocrinol (Oxf) 48:531-546, 1998
8. Khosravi-Far R, Der CJ: The Ras signal transduction pathway. Cancer Metastasis Rev 13:67-89, 1994
9. Ito T, Seyama T, Mizuno T, et al: Unique association of p53 mutations with undifferentiated but not with differentiated carcinomas of the thyroid gland. Cancer Res 52:1369-1371, 1992
10. Chetty R, Goetsch S, Nayler S, et al: Spindle epithelial tumour with thymus-like element (SETTLE): The predominantly monophasic variant. Histopathology 33:71-74, 1998
11. Dorfman DM, Shahsafaei A, Chan JK: Thymic carcinomas, but not thymomas and carcinomas of other sites, show CD5 immunoreactivity. Am J Surg Pathol 21:936-940, 1997
12. Hofman P, Mainguene C, Michiels JF, et al: Thyroid spindle epithelial tumor with thymus-like differentiation (the "SETTLE" tumor): An immunohistochemical and electron microscopic study. Eur Arch Otorhinolaryngol 252: 316-320, 1995
13. Su L, Beals T, Bernacki EG, et al: Spindle epithelial tumor with thymus-like differentiation: A case report with cytologic, histologic, immunohistologic, and ultrastructural findings. Mod Pathol 10:510-514, 1997
14. Andrion A, Bellis D, Delsedime L, et al: Leiomyoma and neurilemoma: Report of two unusual non-epithelial tumours of the thyroid gland. Virchows Arch A 413:367-372, 1988