Genetic alterations in human epithelial thyroid tumours

Clinical Endocrinology

Volumn 48, Issue 5, 1998, Pages 531-546

  Suárez, Horacio G ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER GENETICS; CARCINOGENESIS; GENE ACTIVATION; MULTIGENE FAMILY; ONCOGENE RAS; PRIORITY JOURNAL; REVIEW; THYROID TUMOR;

EID: 0031746157     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1998.00443.x     Document Type: Review

References (103)

1. Barbacid, M. (1987) Ras genes. Annual Review of Biochemistry, 56, 779-827.
2. Barbacid, M., Lamballe, F., Pulido, D. & Klein, R. (1991) The trk family of tyrosine protein kinase receptors. Biochemical Biophysical Acta, 1072, 115-127.
3. Bertherat, J., Chanson, P. & Montminy, M. (1995) The cyclic adenosine 3′-5′-monophosphate-responsive factor CREB is constitutively activated in human somatotroph adenomas. Molecular Endocrinology, 9, 777-783.
4. Bongarzone, I., Butti, M.G., Coronelli, S., Borrello, M.G., Santoro, M., Mondellini, P., Pilotti, S., Fusco, A., Della Porta, G. & Pierotti, M.A. (1994) Frequent activation of ret proto-oncogene by fusion with a new activating gene in papillary thyroid carcinomas. Cancer Research, 54, 2979-2985.
5. Bongarzone, I., Fugazzola, L., Vigneri, P., Mariani, L., Mondellini, P. & Pierotti, M.A. (1996) Age-related activation of the tyrosine kinase receptor protooncogenes RET and NfTRKl in papillary thyroid carcinoma Journal of Clinical Endocrinology and Metabolism, 81, 2006-2009.
6. Bongarzone, I., Monzini, N., Borrello, M.G., Carcano, C., Ferraresi, E., Arighi, E., Mondellini, P., Della Porta, G. & Pierotti, M.A. (1993) Molecular characterization of a thyroid tumor-specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RI of cyclic AMP protein kinase A. Molecular and Cellular Biology, 13, 358-366.
7. Bongarzone, I., Pierotti, M.A., Monzini, N., Mondellini, P., Manenti, G., Donghi, R., Pilotti, S., Grieco, M., Santoro, M., Fusco, A.M., Vecchio, G. & Della Porta, G. (1989) High frequency of activation of tyrosine kinase oncogenes in human papillary thyroid carcinomas. Oncogene, 4, 1457-1462.
8. Bos, J.L., Fearon, E.R., Hamilton, S.R., Verlaan de Vries, M., van Boom, J.H., derEb, A.J. & Vogelstein, B. (1987) Prevalence of ras gene mutations in human colorectal cancers. Nature, 327, 293-297.
9. Bottaro, D.P., Rubin, J.S., Faletto, D.L., Chan, A.M.L., Kurieck, T.E., Van de Woude, G.F. & Aaaronson, S.A. (1991) The hepatocyte growth factor receptor is the c-met proto oncogene product. Silence, 152, 802-804.
10. Bounacer, A., Wicker, R., Caillou, B., Cailleux, A.F., Sarasin, A., Schlumberger, M. & Suárez, H.G. (1997) High prevalence of activating ret proto-oncogene rearrangements, in thyroid tumors from patients who had received external radiation. Oncogene, 15, 1263-1273.
11. Challeton, C., Bounacer, A., Du Villard, J.A., Caillou, B., De Vathaire, F., Monier, R., Schlumberger, M. & Suárez, H.G. (1995) Pattern of ras and gsp oncogene mutations in radiation-associated human thyroid tumors. Oncogene, 11, 601-603.
12. Curtis, L., Wyllie, A.H., Saw, J.J., Williams, G.T., Radulescu, A., De Micco, C., Haugen, D.R.F., Varghaug, J.E., Lillehang, J.R. & Wynford-Thomas, D. (1994) Evidence against involvement of APC mutation in Papillary thyroid carcinoma. European Journal of Cancer, 30, 984-987.
13. Daya-Grosjean, L., Robert, C., Drougard, Ch., Suárez, H.G. & Sarasin, A. (1993) High mutation frequency in ras genes of skin tumors isolated from DNA repair deficient Xeroderma pigmentosum patients. Cancer Research. 53, 1625-1629.
14. Delvincourt, C., Patey, M., Flament, J.B., Suárez, H.G., Larbre, H., Jardillier, J.C. & Delisle, M.J. (1996) Ret and trk proto-oncogene activation in thyroid papillary carcinomas in French patients from the Champagne-Ardenne region. Clinical Biochemistry, 29, 267-271.
15. Di Renzo, M.F., Olivero, M., Ferro, S., Prat, M., Bongarzone, I., Pilotti, S., Belfiore, A., Costantino, A., Vigneri, R., Pierotti, M.A. & Comoglio, P.M. (1992) Overexpression of the c-met/HGF receptor gene in human thyroid carcinomas. Oncogene, 7, 2549-2553.
16. Donis-Keller, H., Dou, S., Chi, D., Carlsson, K.M., Toshima, K., Lairmore, T., Howe, J.R., Moley, J.F., Goodfellow, P. & Wells, S.R. Jr (1993) Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC. Human Molecular Genetics, 2, 851-856.
17. Du Villard, J.A., Schlumberger, M., Wicker, R., Caillou, B., Rochefort, P., Feunteun, J., Monier, R., Parmentier, C. & Suárez, H.G. (1995) Role of ras and gsp oncogenes in human epithelial thyroid tumorigenesis. Journal of Endocrinological Investigation, 18, 124-126.
18. Durbec, P., Marcos-Gutierrez, C., Kilkenny, C., Grigoriou, M., Wartiowaara, K., Suranto, P., Smith, D., Pondern, B., Costantini, F., Saarma, M., Sariola, H. & Pachniss, V. (1996) GDNF signalling through the RET receptor tyrosine kinase. Nature, 381, 789-793.
19. Eng, C., Smith, D.P., Mulligan, L.M., Nagai, M.A., Healey, C.S., Ponder, M.A., Gardner, E., Scheumann, G.F.W., Jackson, C.E., Tunnacliffe, A. & Ponder, B.A.J. (1994) Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia 2B and related sporadic tumors. Human Molecular Genetics, 3, 237-241.
20. Fagin, J.A. (1992) Genetic basis of endocrine disease 3. Molecular defects in thyroid gland neoplasic. Journal of Clinical Endocrinology and Metabolism, 75, 1398-1410.
21. Fearon, E.R. & Vogelstein, B. (1990) A genetic model for colorectal tumorigenesis. Cell, 61, 759-767.
22. Fogelfeld, L., Bauer, T.K., Schneider, A.B., Schwanz, J.E. & Zitman, R. (1996) p53 gene mutations in radiation-induced thyroid cancer. Journal of Clinical Endocrinology and Metabolism, 81, 3039-3044.
23. Fugazzola, L., Pierotti, M.A., Vigano, E., Pacini, F., Vorontsova, T.V. & Bongarzone, I. (1996) Molecular and biochemical analysis of RET/PTC4 a novel oncogenic rearrangement between RET and ELE1 genes in a post-Chernobyl papillary thyroid cancer. Oncogene, 13, 1093-1097.
24. Fugazzola, L., Pilotti, S., Pincheira, A., Vorontsova, T.V., Mondellini, P., Bongarzone, I., Greco, A., Astakhova, L., Butti, M.G., Demidchick, E.P., Pacini, F. & Pierotti, M.A. (1995) Oncogenic rearrangements of the RET proto-oncogene in papillary thyroid carcinomas from children exposed to the Chernobyl nuclear accident. Cancer Research, 55, 5617-5620.
25. Fusco, A.M., Grieco, M., Santoro, M., Berlinghieri, M.T., Pilotti, S., Pierotti, M. A., Della Porta, G. & Vecchio, G. (1987) A new oncogene in human papillary carcinomas and their lymph-nodal metastases. Nature. 328, 170-172.
26. Giordano, S., Ponzetto, C., Di Renzo, M.F., Cooper, C.S. & Comoglio, P.M. (1989) Tyrosine kinase receptor indistinguishable from the c-met protein. Nature. 339, 155-156.
27. Gonzatti-Haces, M., Seth, A., Park, M., Copeland, T., Oroszland, S. & Van de Woude, G.F. (1988) Characterization of the tpr-met oncogene p65 and the met proto-oncogene p140 protein tyrosine kinases. Proceedings of the National Academy of Sciences, USA, 85, 21-25.
28. Greco, A., Mariani, C., Miranda, C., Lupas, A., Pagliardini, S., Pomati, M. & Pierotti, M.A. (1995) The DNA rearrangement that generates the TRK T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain. Molecular and Cellular Biology, 15, 6118-6127.
29. Greco, A., Pierotti, M.A., Bongarzone, I., Pagliardini, S., Lanzi, C. & Della Porta, G. (1992) Trk-T1 is a novel oncogene formed by the fusion of tpr and trk genes in human papillary thyroid carcinomas. Oncogene, 7, 237-242.
30. Grieco, M., Santoro, M., Berlinghieri, M.T., Melillo, R.M., Donghi, R., Bongarzone, I., Pierotti, M.A., Della Porta, G., Fusco, A. & Vecchio, G. (1990) PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. Cell, 60, 557-563.
31. Hamacher, C., Studer, H., Zbaeren, J., Schatz, H. & Derwahl, M. (1995) Expression of a functional stimulatory guanine nucleotide binding protein in non-functioning thyroid adenomas is not correlated to adenyl cyclase activity and growth of these tumors. Journal of Clinical Endocrinology and Metabolism. 80, 1724-1732.
32. Hollstein, M., Shower, B., Greenblat, M., Soussi, T., Hovig, E., Montesano, R. & Harris, C. (1996) Somatic point mutations in the p53 gene of human tumor cell lines: updated compilation. Nucleic Acid Research, 24, 141-146.
33. Ikeda, I., Ishizaka, Y., Tahira, T., Suzuki, T., Onda, M.T., Sugimura, T. & Nagao, M. (1990) Specific expression of the ret proto-oncogene in human neuroblastoma cell lines. Oncogene, 5, 1291-1296.
34. Ishizaka, Y., Kobayashi, S., Ushijima, T., Hirohashi, S., Sugimura, T. & Nagao. M. (1991) Detection of ret TPC/PTC transcripts in thyroid adenomas and adenomatous goiter by an RT-PCR method. Oncogene, 6, 1667-1672.
35. Ito, T., Seyamu, T., Iwamoto, K.S., Mizuno, T., Tronko, N.D., Komissarenko, I.V., Cherstovoy, E.D., Satow, Y., Takeichi, N., Dohi, K. & Akiyama, N. (1994) Activated RET oncogene in thyroid cancers of children from areas contaminated by Chernobyl accident. Lancet, 344, 259.
36. Ito, T., Seyama, T., Mizuno, T., Tsuyama, N., Hayashi, T., Hayashi, Y., Dohi, K., Nakamura, N. & Akiyama, N. (1992) Unique association of p53 mutations with undifferentiated hut not with differentiated carcinomas of the thyroid gland. Cancer Research, 52, 1369-1371.
37. Ivan, M., Bond, J.A., Prat, M., Comoglio, P.M. & Wynford-Thomas, D. (1997) Activated ras and ret oncogenes induce over-expression of c-met (hepatocyte growth factor receptor) in human thyroid epithelial cells. Oncogene, 14, 2417-2423.
38. PTC oncogene in human thyroid cancers. Oncogene. 7, 1331-1337.
39. Jhiang, S.M., Sagartz., J.E., Tong, Q., Parker-Thornburg, J., Capen, C.C., Cho, J.Y., Xing, S. & Ledent, C. (1996) Targeted expression of the RET/PTC1 oncogene induces papillary thyroid carcinomas. Endocrinology, 137, 375-378.
40. Karga, H., Lee, J.K., Vickery, A.L., Thor, A., Gaz., R.D. & Jameson, J.L. (1991) Ras oncogene mutations in benign and malignant thyroid neoplasms. Journal of Clinical Endocrinology and Metabolism, 73, 832-836.
41. Klein, R., Jing, S., Nanduri, V., O'Rourke, E. & Barhacid, M. (1991) The trk proto-oncogene encodes a receptor for nerve growth factor. Cell, 65, 189-197.
42. Klugbauer, S., Lengfelder, E., Demidchick, E.P. & Rabes, H.M. (1995) High prevalence of RET rearrangements in thyroid tumors of children from Belarus after the Chernobyl accident. Oncogene, 11, 2459-2467.
43. Klugbauer, S., Lengfelder, E., Demidchik, E.P. & Rabes, H.M. (1996) A new form of RET rearrangement in thyroid carcinomas of children after the Chernobyl accident. Oncogene, 13, 1099-1102.
44. Lefkowitz., R.J. (1995) G proteins in medicine. New England Journal of Medicine, 332, 186-187.
45. Lenioine, N.R., Mayall, E.S., Williams, E.D., Thurston, V. & Wynford-Thomas, D. (1988a) Agent specific ras oncogene activation in rat thyroid tumors. Oncogene, 3, 541-544.
46. Lemoine, N.R., Mayall, E.S., Wyllie, F.S., Farr, C.J., Hughes, D., Padua, R.A., Thurston, V., Williams, E.D. & Wynford-Thomas, D. (1988b) Activated ras oncogenes in human thyroid cancers. Cancer Research, 48, 4459-4463.
47. Lemoine, N.R., Mayall, E.S., Wyllie, F.S., Williams, E.D., Goyns, M., Stringer, B. & Wynford-Thomas, D. (1989) High frequence of ras oncogene activation in all stages of human thyroid tumorigenesis. Oncogene, 4, 159-164.
48. Lyons, J., Landis, C.A., Harsh, G., Vallar, L., Grunewald, K., Feichtinger, H., Duh, Q.Y., Clark, O.H., Kawasaki, E., Bourne, H.R. & McCormick, F. (1990) Two G protein oncogenes in human endocrine tumors. Science, 249, 655-659.
49. Martin-Zanca, D., Barbacid, M. & Parada, L. (1990) Expression of the trk protooncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development. Gene and Development, 4, 683-694.
50. Martin-Zancz, D., Hughes, S.H. & Barbacid, M. (1986) A human oncogene formed by fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature, 319, 743-748.
51. Matsuo, K., Tang, S.H. & Fagin, J.A. (1991) Allelotype of human thyroid tumors: loss of chromosome 11q13 sequences in follicular neoplasms. Molecular Endocrinology, 5, 1873-1879.
52. Michelin, S., Daya-Grosjean, L., Sureau, F., Sarasin, A. & Suárez, H.G. (1993) Characterization of a c-met proto-oncogene activated in human xeroderma pigmentosum cells after treatment with N-methyl-N-nitro-N-nitrosoguanidine (MNNG). Oncogene, 8, 1983-1991.
53. Michiels, F., Caillou, B., Talbot, M., Dessarps-Freicher, F., Maunoury, M.T., Schlumberger, M., Merckens, L., Monier, R. & Feunteun, J. (1994) Oncogenic potential of guanine nucleotide stimulatory factor alpha subunit in thyroid glands of transgenic mice. Proceedings of the National Academy of Sciences, USA, 91, 10488-10492.
54. Nagayama, Y., Kaufman, K.D., Seto, P. & Rapoport, B. (1989) Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor. Biochemical and Biophysical Research Communications, 165, 1184-1190.
55. Naldini, L., Vigna, E., Narsinham, R., Gaudino, G., Zarnegar, R., Michalopoulos, G.K. & Comoglio, P.M. (1991) Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-met. Oncogene, 6, 501-504.
56. Namba, H., Rubin, S. & Fagin, J.A. (1990) Point mutations of ras oncogenes are an early event in thyroid tumorigenesis. Molecular Endocrinology, 4, 1474-1479.
57. Nikiforov, Y.E., Nikiforova, M.V., Gnepp, D.R. & Fagin, J.A. (1996) Prevalence of mutations of ras and p53 in benign and malignant thyroid tumors from children exposed to radiation after the Cheniobyl nuclear accident. Oncogene, 13, 687-693.
58. Nikiforov, Y.E., Rowland, J.M., Bove, K.E., Monforte-Muñoz, H. & Fagin, J. (1997) Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadicthyroid papillary carcinomas in children. Cancer Research, 57, 1690-1694.
59. O'Sullivan, C.O., Barton, C.M., Staddon, S.L., Brown, C.L. & Lemoine, N.R. (1991) Activating point mutations of the gsp oncogene in human thyroid adenomas. Molecular Carcinogenesis, 4, 345-349.
60. Pachniss, V., Manchoo, B. & Costantini, F. (1993) Expression of the c-net proto-oncogene during mouse embryogenesis. Development, 119, 1005-1017.
61. Park, M., Dean, M., Cooper, C.S., Schmidt, M., O'Brien, S.J., Blair, D.G. & Van de Woude, G.F. (1986) Mechanism of met oncogene activation. Cell, 45, 895-904.
62. Parma, J., Duprez, L., Van Sande, J., Cochaux, P., Gervy, Ch., Mockel, J., Dumont, J. & Vassart, G. (1993) Somatic mutations in the thyrotropin receptor gene cause hyperfunctionning thyroid adenomas. Nature, 365, 649-651.
63. 2+ cascades. Molecular Endocrinology, 9, 725-733.
64. Paschke, R., Tonacchera, M., Van Sande, J., Parma, J. & Vassart, G. (1994) Identification and functional characterization of two new somatic mutations causing constitutive activation of the thyrotropin receptor in hyperfunctioning autonomous adenomas of the thyroid. Journal of Clinical Endocrinology and Metabolism, 79, 1785-1789.
65. Pierotti, M.A., Santoro, M., Jenkins, R.B., Sozzi, G., Bongarzone, L., Grieco, M., Monzini, N., Miozzo, M., Hermann, M.A., Fusco, A., Hay, I.D., Della Porta, G. & Vecchio, G. (1992) Characterization of a chromosome 10q inversion juxtaposing ret and H4 genes and creating the oncogenic sequence PTC. Proceedings of the National Academy of Sciences, USA, 89, 1616-1620.
66. Porcellini, A., Ciullo, I., Laviola, L., Amabile, G., Fenzi, G. & Avvedimento, V.E. (1994) Novel mutations of thyrotropin receptor in thyroid hyperfunctioning adenomas. Rapid identification by fine needle aspiration biopsy. Journal of Clinical Endocrinology and Metabolism, 79, 657-661.
67. Rochefort, P., Caillou, B., Michiels, F.M., Ledent, C., Talbot, M., Schlumberger, M., Lavelle, F., Monier, R. & Feunteun, J. (1996) Thyroid pathologies in transgenic mice expressing a human activated ras gene driven by thyroglobulin promoter. Oncogene, 12, 111-118.
68. Rodrigues, G.A. & Park, M. (1993) Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinase. Molecular and Cellular Biology, 13, 6711-6722.
69. Russo, D., Arturi, F., Schlumberger, M., Caillou, B., Monier, R., Filetti, S. & Suárez, H.G. (1995a) Activating mutations of the TSH receptor in differentiated thyroid carcinomas. Oncogene, 11, 1907-1911.
70. Russo, E., Arturi, F., Wicker, R., Chazenbalk, G.D., Schlumberger, M., Du Villard, J.A., Caillou, B., Monier, R., Rappaport, B., Filetti, S. & Suárez, H.G. (1995b) Genetic alterations in thyroid hyperfunctioning adenomas. Journal of Clinical Endocrinology and Metabolism, 80, 1347-1351.
71. Russo, D., Arturi, F., Suárez, H.G., Schlumberger, M., Du Villard, J.A., Crocetti, V. & Filetti, S. (1996) Thyrotropin receptor gene alterations in thyroid hyperfunctioning adenomas. Journal of Clinical Endocrinology and Metabolism, 81, 1548-1551.
72. Saïd, S., Schlumberger, M. & Suárez, H.G. (1994) Oncogenes and anti-oncogenes in human epithelial thyroid tumors. Journal of Endocrinological Investigation, 17, 371-379.
73. Santelli, G., de Franciscis, V., Portella, G., Chiappetta, G., D'Alesio, A., Califano, D., Rosti, R., Mineo, A., Monaco, C., Manzo, G., Pozzi, L, & Vecchio, G. (1993) Production of transgenic mice expressing Kiras oncogene under the control of a tyroglobulin promoter. Cancer Research, 53, 5523-5527.
74. Santoro, M., Carlomagno, F., Hay, I.D., Herrmann, M.A., Grieco, M., Melillo, R.M., Pierotti, M.A., Bongarzone, I., Della Porta, G., Berger, N., Peix, J.L., Paulin, Ch., Fabien, N., Vecchio, G., Jenkins, R.B. & Fusco, A. (1992) Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype. Journal of Clinical Investigation, 89, 1517-1522.
75. Santoro, M., Chiapetta, G., Cerrato, A., Salvatore, D., Zhang, L., Manzo, G., Picone, A., Portella, G., Santelli, G., Vecchio, G. & Fusco, A. (1996) Development of thyroid papillary carcinomas secondary to tissue-specific expression of the RET/PTC1 oncogene in transgenic mice. Oncogene, 12, 1821-1826.
76. Santoro, M., Dathan, N.A., Berlingieri, M.T., Bongarzone, I., Paulin, C., Grieco, M., Pierotti, M.A., Vecchio, G. & Fusco, A. (1994) Molecular characterization of RET/PTC3, a novel rearranged version of the RET proto-oncogene in a human thyroid papillary carcinoma. Oncogene, 9, 509-516.
77. Santoro, M., Rosati, R., Grieco, M., Berlinghieri, M.T., D'Amato, G.L.C., de Franciscis, V. & Fusco, A. (1990) The ret proto-oncogene is consistently expressed in human pheocromocytomas and thyroid medullary carcinomas. Oncogene, 5, 1595-1598.
78. Schuhardt, A., D'Agati, V., Larsson-Blonberg, L., Costantini, F. & Pachniss, V. (1994) Defects in the kidney and enteric nervous system of mice laking the tyrosine kinase receptor RET. Nature, 367, 380-383.
79. Shi, Y., Schmidt, H., Juhasz, F., Stensky, V., Robb, D. & Farid, N.R. (1991) High rates of ras codon 61 mutations in thyroid tumors in a iodine-deficient area. Cancer Research, 51, 2690-2693.
80. Spiegel, A.M. (1996) Mutations in G proteins and G protein-coupled receptors in endocrine disease. Journal of Clinical Endocrinology and Metabolism. 81, 2434-2442.
81. Suárez, H.G. (1989) Activated oncogenes in human tumors. Anticancer Research, 9, 1331-1344.
82. Suárez, H.G., Du Villard, J.A., Caillou, B., Schlumberger, M., Parmentier, C. & Monier, R. (1991) Gsp mutations in human thyroid tumors. Oncogene, 6, 677-679.
83. Suárez, H.G., Du Villard, J.A., Caillou, B., Schlumberger, M., Tubiana, M., Parmentier, C. & Monier, R. (1988) Detection of activated ras oncogenes in human thyroid carcinomas. Oncogene, 2, 403-406.
84. Suárez, H.G., Du Villard, J.A., Severino, M., Caillou, B., Schlumberger, M., Tubiana, M., Parmentier, C. & Monier, R. (1990) Presence of mutations in all three ras genes in human thyroid tumors. Oncogene, 5, 565-570.
85. Sugg, S.L., Zheng, L., Rosen, I.B., Freeman, J.L., Ezzat, S. & Asa, S.L. (1996) RET/PTC1, 2 and 3 oncogene rearrangements in human thyroid carcinomas: implications for metastatic potential? Journal of Clinical Endocrinology and Metabolism, 81, 3360-3365.
86. Takahashi, M (1995) Oncogenic activation of the ret proto-oncogene in thyroid cancer. Critical Reviews in Oncogenesis, 6, 35-46.
87. Takeshita, A., Nagayama, Y., Yokoyama, N., Ishikawa, N., Ito, K., Yamashita, T., Obara, T., Murakami, Y., Kuma, K., Takamatsu, J., Ohsawa, N. & Nagataki, S. (1995) Rarity of oncogenic mutations in the thyrotropin receptor of autonomously functioning thyroid nodules in Japan. Journal of Clinical Endocrinology and Metabolism, 80, 2607-2611.
88. Trupp, M., Arenas, E., Fainzilber, M., Nilsson, A.S., Sieber, B.A., Grigoriou, M., Kilkenny, C., Salazar-Grucso, E., Pachniss, V., Arumao, U., Sariola, H., Saarma, M. & Ibañez, C.F. (1996) Functional receptor for GDNF encoded by the c-ret proto-oncogene. Nature, 381, 785-789.
89. Van Sande, J., Parma, J., Tonacchera, M., Swillems, S., Dumont, J. & Vassart, G. (1995) Somatic and germline mutations of the TSH receptor gene in thyroid diseases. Journal of Clinical Endocrinology and Metabolism, 80, 2577-2585.
90. Viglietto, G., Chiappetta, G., Martinez-Tello, F.J., Fukunaga, F.H., Tallini, G., Rigoupoulou, D., Visconti, R., Mastro, A., Santoro, M. & Fusco, A. (1995) RET/PTC oncogene activation is an early event in thyroid carcinogenesis. Oncogene. 11, 1207-1210.
91. Wagner, S. & Green, M.R. (1991) Retinoblastoma: a transcriptional trys. Nature, 352, 189-190.
92. Wajjwalku, W., Nakamura, S., Hasegawa, Y., Miyasaki, K., Satoh, Y., Funahashi, H., Matzuyama, M. & Takahashi, M. (1992) Low frequency of rearrangements of the ret and trk proto-oncogenes in Japanese thyroid papillary carcinomas. Japanese Journal of Cancer Research, 83, 671-675.
93. Weidner, K.M., Behrens, J., Vanderkerckhove, J. & Birchmaier, W. (1990) Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells. Journal of Cell Biology, 111, 2907-2911.
94. Wicker, R. & Suárez, H.G, (1996) Le facteur de croissance des hépatocytes (HGF-SF) et son récepteur c-met. Médecine/Sciences, 12, 313-322.
95. Williams, E.D., Toyn, C.E. & Harach, H.R. (1989) The ultimobranchial gland and congenital thyroid abnormalities in man. Journal of Pathology, 159, 135-140.
96. Wright, N.A. (1990) Endocrine cells in non-endocrine tumors. Journal of Pathology, 161, 85-90.
97. Wright, P., Williams, E.D., Lemoine, N.R. & Wynford-Thomas, D. (1991) Radiation associated and spontaneous human thyroid carcinomas show a different pattern of ras oncogene mutation. Oncogene, 6, 471-473.
98. Wynford-Thomas, D. (1993a) Molecular basis of epithelial tumori-genesis: the thyroid model. Critical Reviews in Oncogenesis, 4, 1-23.
99. Wynford-Thomas, D. (1993b) Origine et progression des tumeurs épitheliales: vers les mécanismes cellulaires et moléculaires. Médecine/Sciences, 9, 66-75.
100. Yashimoto, K., Iwuhunu, H., Fukuda, A., Sano. T. & Itakura, M. (1993) Rare mutations of the Gs alpha subunit gene in human endocrine tumors. Cancer, 72, 1386-1393.
101. Yashimoto, K., Iwahana, H., Fukuda, A., Sano, T., Saito, G. & Itakura, M. (1992) Role of p53 mutations in endocrine tumorigenesis: mutations detection by polymerase chain reaction-single strand conformation polymorphism. Cancer Research, 52, 5061-5064.
102. Zarnegar, R., Muga, S., Rahija, R.J. & Michalopoulos, G. (1989) Tissue distribution of hepatoprotein A: heparin binding polypeptide growth factor for hepatocytes. Proceedings of the National Academy of Sciences, USA, 87, 1252-1255.
103. PTC) in papillary thyroid carcinoma from Saudi Arabia. Cancer, 73, 176-180.