Life-threatening infantile diarrhea from fluoroquinoloneresistant Salmonella enterica Typhimurium with mutations in both gyrA and parC

Emerging Infectious Diseases

Volumn 9, Issue 2, 2003, Pages 255-257

  Nakaya, Hideo ^a   Yasuhara, Akihiro ^a   Yoshimura, Ken ^a   Oshihoi, Yukio ^a   Izumiya, Hidemasa ^b   Watanabe, Haruo ^b  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMPICILLIN; CEFACLOR; CEFAZOLIN; CEFTAZIDIME; CEFTRIAXONE; CHLORAMPHENICOL; COTRIMOXAZOLE; DNA TOPOISOMERASE (ATP HYDROLYSING) A; FOSFOMYCIN; GENE PRODUCT; GENTAMICIN; IMIPENEM; KANAMYCIN; LEVOFLOXACIN; NALIDIXIC ACID; PROTEIN PARC; QUINOLINE DERIVED ANTIINFECTIVE AGENT; STREPTOMYCIN; TETRACYCLINE; UNCLASSIFIED DRUG;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL MUTATION; BACTERIAL STRAIN; CASE REPORT; CLINICAL FEATURE; DISEASE COURSE; HUMAN; INFANTILE DIARRHEA; JAPAN; LABORATORY DIAGNOSIS; LIVESTOCK; MALE; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; NEWBORN; SALMONELLA ENTERICA; SEQUENCE ANALYSIS; TREATMENT OUTCOME;

EID: 0037326990     PISSN: 10806040     EISSN: None     Source Type: Journal    
DOI: 10.3201/eid0902.020185     Document Type: Article

References (18)

1. Threlfall EJ, Frost JA, Ward LR, Rowe B. Increasing spectrum of resistance in multiresistant Salmonella typhimurium. Lancet 1996;347:1053-4.
2. Glynn MK, Bopp C, Dewitt W, Dabney P, Mohter M, Angulo F. Emergence of multidrug-resistant Salmonella enterica serotype Typhimurium DT104 infections in the United States. N Engl J Med 1998;338:1333-7.
3. Threlfall EJ, Hampton MD, Schofield SL, Ward LR, Frost JA, Rowe B. Epidemiological application of differentiating multiresistant Salmonella typhimurium DT104 by plasmid profile. Commun Dis Rep CDR Rev 1996;6:R155-9.
4. Threlfall EJ, Ward LR, Skinner JA, Rowe B. Increase in multiple antibiotic resistance in nontyphoidal salmonellas from humans in England and Wales: a comparison of data for 1994 and 1996. Microb Drug Resist 1997;3:263-6.
5. Molbak K, Baggesen DL, Aarestrup FM, Ebbesen JM, Engberg J, Frydendahl K, et al. An outbreak of multidrug-resistant, quinolone-resistant Salmonella enterica serotype Typhimurium DT104. N Engl J Med 1999;341:1420-5.
6. Hakanen A, Siitonen A, Kotilainen P, Huovinen P. Increasing fluoroquinolone resistance in salmonella serotypes in Finland during 1995-1997. J Antimicrob Chemother 1999;43:145-8.
7. Nakaya H, Yasuhara A, Yoshimura K, Oshihoi Y, Izumiya H, Watanabe H. Multi-drug resistant and fluoroquinorone-resistant Salmonella enterica serotype Typhimurium definitive phage type 12 isolated from infantile diarrhea. [Japanese] Journal of the Japanese Association for Infectious Diseases 2001;75:815-8.
8. National Committee for Clinical Laboratory Standards. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically: approved standard. 5th ed. Vol. 20, No.2. Wayne (PA): the Committee; 2000.
9. Giraud E, Brisabois A, Martel JL, Chaslus-Dancla E. Comparative studies of mutations in animal isolates and experimental in vitro- and in vivoselected mutants of Salmonella spp. suggest a counterselection of highly fluoroquinolone-resistant strains in the field. Antimicrob Agents Chemother 1999;43:2131-7.
10. Sanger F, Nicklen S, Coulson AR. DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A 1977;74:5463-7.
11. Matsushita S, Konishi N, Arimatsu M, Kai A, Yamada S, Morozumi S. Drug-resistance and definitive type 104 of Salmonella serovar Typhimurium isolated from sporadic cases in Tokyo, 1980-1998. [Japanese] Journal of the Japanese Association for Infectious Diseases 1999;73:1087-94.
12. Izumiya H, Terajima J, Matsushita S, Tamura K, Watanabe H. Characterization of multidrug-resistant Salmonella enterica serovar Typhimurium isolated in Japan. J Clin Microbial 2001;39:2700-3.
13. Brown JC, Thomson CJ, Amyes SG. Mutation of the gyrA gene of clinical isolates of Salmonella typhimurium and three other Salmonella species leading to decreased susceptibilities to 4-quinolone drugs. J Antimicrob Chemother 1996;37:351-6.
14. Heisig P. Genetic evidence for a role of parC mutations in development of high-level fluoroquinolone resistance in Escherichia coli. Antimicrob Agents Chemother 1996;40:879-85.
15. Nishino Y, Deguchi T, Yasuda M, Kawamura T, Nakano M, Kanematsu E, et al. Mutations in the gyrA and parC genes associated with fluoroquinolone resistance in clinical isolates of Citorobacter freundii. FEMS Microbiol Lett 1997;154:409-14.
16. Piddock LJ. Fluoroquinolone resistance in Salmonella serovars isolated from humans and food animals. FEMS Microbial Rev 2002;26:3-16.
17. Olsen SJ, DeBess EE, McGivern TE, Marano N, Eby T, Mauvais S, et al. A nosocominal outbreak of fluoroquinorone-resistant salmonella infection. N Engl J Med 2001;344:1572-9.
18. Matsushita S, Yamada S, Sekiguchi K, Kusunoki J, Ohta K, Kudoh Y. Serovar-distribution and drug-resistance of Salmonella strains isolated from domestic and imported cases in Tokyo. [Japanese] Journal of the Japanese Association for Infectious Diseases 1996;70:42-50.