Mutations in the gyrA and parC genes associated with fluorquinolone resistance in clinical isolates of Citrobacter freundii

FEMS Microbiology Letters

Volumn 154, Issue 2, 1997, Pages 409-414

  Nishino, Yoshinori ^a   Deguchi, Takashi ^a   Yasuda, Mitsuru ^a   Kawamura, Takeshi ^a   Nakano, Masahiro ^a   Kanematsu, Emiko ^a   Ozeki, Shigehiko ^a   Kawada, Yukimichi ^a  

^a GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Citrobacter freundii; DNA gyrase; Topoisomerase IV

Indexed keywords

AZTREONAM; CEFAZOLIN; CEFIXIME; CEFOTAXIME; CIPROFLOXACIN; DNA TOPOISOMERASE (ATP HYDROLYSING); GENTAMICIN; IMIPENEM; NORFLOXACIN; PIPERACILLIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TETRACYCLINE;

ANTIBIOTIC RESISTANCE; ARTICLE; CITROBACTER FREUNDII; CONTROLLED STUDY; JAPAN; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TREATMENT FAILURE; URINARY TRACT INFECTION;

AMINO ACID SEQUENCE; ANTI-INFECTIVE AGENTS; BASE SEQUENCE; CITROBACTER FREUNDII; DNA GYRASE; DNA TOPOISOMERASE IV; DNA TOPOISOMERASES, TYPE II; DRUG RESISTANCE, MICROBIAL; FLUOROQUINOLONES; GENE AMPLIFICATION; GENES, BACTERIAL; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; URINARY TRACT INFECTIONS;

CITROBACTER FREUNDII;

EID: 0030763523     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(97)00361-3     Document Type: Article

References (17)

1. von Rosenstiel, N. and Adam, D. (1994) Quinolone antibacterials. An update of their pharmacology and therapeutic use. Drugs 47, 872-901.
2. Nikaido, H. (1994) Prevention of drug access to bacterial targets: permeability barriers and active efflux. Science 264, 382-388.
3. Kato, J-I., Nishimura, Y., Imamura, R., Niki, H., Hiraga, S. and Suzuki, H. (1990) New topoisomerase essential for chromosome segregation in Escherichia coli. Cell 63, 393-404.
4. Masuda, N., Sakagawa, E. and Ohya, S. (1995) Outer membrane proteins responsible for multiple drug resistance in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 39, 645-649.
5. Swanberg, S.L. and Wang, J.C. (1987) Cloning and sequencing of the Escherichia coli gyrA gene coding for the A subunit of DNA gyrase. J. Mol. Biol. 197, 729-736.
6. Yoshida, H., Bogaki, M., Nakamura, M. and Nakamura, S. (1990) Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli. Antimicrob. Agents Chemother. 34, 1271-1272.
7. Belland, R.J., Morrison, S.G., Ison, C. and Huang, W.M. (1994) Neisseria gonorrhoeae acquires mutations in analogous regions of gyrA and parC in fluoroquinolone-resistant isolates. Mol. Microbiol. 14, 371-380.
8. Deguchi, T., Yasuda, M., Asano, M., Tada, K., Iwata, H., Komeda, H., Ezaki, T., Saito, I. and Kawada, Y. (1995) DNA gyrase mutations in quinolone-resistant clinical isolates of Neisseria gonorrhoeae. Antimicrob. Agents Chemother. 39, 561-563.
9. Georgiou, M., Munoz, R., Roman, F., Canton, R., Gomez-Lus, R., Campos, J. and De la Campa, A.G. (1996) Ciprofloxacin-resistant Hemophilus influenzae strains possess mutations in analogous positions GyrA and ParC. Antimicrob. Agents Chemother. 40, 1741-1744.
10. Deguchi, T., Yasuda, M., Nakano, M., Ozeki, S., Ezaki, T., Saito, I. and Kawada, Y. (1996) Quinolone-resistant Neisseria gonorrhoeae; Correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles. Antimicrob. Agents Chemother. 40, 1020-1023.
11. Vila, J., Ruiz, J., Goni, P. and Jimenez de Anta, M.T. (1996) Detection of mutations in parC in quinolone-resistant clinical isolates of Escherichia coli. Antimicrob. Agents Chemother. 40, 491-493.
12. Kumagai, Y., Kato, J-I., Hoshino, K., Akasaka, T., Sato, K. and Ikeda, H. (1996) Quinolone-resistant mutants of Escherichia coli DNA topoisomerase IV parC gene. Antimicrob. Agents Chemother. 40, 710-714.
13. Hirai, K., Hosaka, M., Niwata, Y., Yasue, T., Fukuda, H., Ishizaki, T., Suzue, S. and Nishino, K. (1990) Antibacterial activity of AM-1155, a new quinolone. Program Abstr. 30th Intersci. Conf. Antimicrob. Agents Chemother. abstr. 385.
14. Alos, J-I., Lambert, T. and Courvalin, P. (1993) Comparison of two molecular methods for tracing nosocomial transmission of Escherichia coli K1 in a neonatal unit. J. Clin. Microbiol. 31, 1704-1709.
15. Wang, Y., Huang, W.M. and Taylor, D.E. (1993) Cloning and nucleotide sequence of the Campylobacter jejuni gyrA and characterization of quinolone resistance mutations. Antimicrob. Agents Chemother. 37, 457-463.
16. Takiff, H.E., Salzar, L., Guerrero, C., Philipp, W., Huang, W.M., Kreiswirth, B., Cole, S.T., Jacobs Jr., W.R. and Telenti, A. (1994) Cloning and nucleotide sequence of Mycobacterium tuberculosis gyrA and gyrB genes and detection of quinolone resistance mutations. Antimicrob. Agents Chemother. 38, 773-780.
17. Ferrero, L., Cameron, B., Manse, B., Lagneaux, D., Crouzet, J., Famechon, A. and Blanche, F. (1994) Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones. Mol. Microbiol. 13, 641-653.