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Angdin M, Settergren G, Vaage J. Better preserved pulmonary endothelium-dependent vasodilation with off-pump coronary surgery. Scand Cardiovasc J 2001; 35:264-269. A clinically relevant study which should encourage further clinical investigations to be performed in the field of off-pump cardiac surgery.
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Haraldsson SA, Kieler-Jensen N, Ricksten SE. The additive pulmonary vasodilatory effects of inhaled prostacyclin and inhaled milrinone in postcardiac surgical patients with pulmonary hypertension. Anesth Analg 2001; 93:1439-1445. A very interesting clinical study, adding new therapeutic options to the conventional treatment of postoperative pulmonary hypertension after cardiac surgery.
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Lang JD Jr, Lell W. Pro: inhaled nitric oxide should be used routinely in patients undergoing lung transplantation. J Cardiothorac Vasc Anesth 2001; 15:785-789. Excellent well written articles providing a good overview of the actual discussion.
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Delgado JF, Gomez-Sanchez MA, Saenz dlC, et al. Impact of mild pulmonary hypertension on mortality and pulmonary artery pressure profile after heart transplantation. J Heart Lung Transplant 2001; 20:942-948. An important retrospective study evaluating even mild pulmonary hypertension as an important risk factor for early postoperative mortality after heart transplantation.
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Delgado, J.F.1
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Langer F, Wendler O, Wilhelm W. Treatment of a case of acute right heart failure by inhalation of iloprost, a long-acting prostacyclin analogue. Eur J Anaesthesiol 2001; 18:770-773. An interesting case report which should encourage the investigation of iloprost for the treatment of acute right heart failure in clinical studies.
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2 sensors, and controversies. News Physiol Sci 2002; 17:131-137. An excellent review providing a very interesting overview of the actual theories for the mechanism of hypoxic pulmonary vasoconstriction.
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Chest
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Blumberg, F.C.1
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Olschewski H, Simonneau G, Galie N, et al. Inhaled iloprost for severe pulmonary hypertension. N Engl J Med 2002; 347:322-329. Certainly the most important study with regard to the effects of iloprost in pulmonary hypertension because this study demonstrated an improvement of relevant outcome parameters.
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Michelakis E, Tymchak W, Lien D. Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension: comparison with inhaled nitric oxide. Circulation 2002; 105:2398-2403. New data about the use of phosphodiesterase inhibitors in pulmonary hypertension.
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Michelakis, E.1
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Ghofrani HA, Wiedemann R, Rose F, et al. Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension. Ann Intern Med 2002; 136:515-522. A reasonable study evaluating the promising combination of iloprost and phosphodiesterase inhibitors in pulmonary hypertension.
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Ann Intern Med
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Ghofrani, H.A.1
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Urodilatin, a natriuretic peptide stimulating particulate guanylate cyclase, and the phosphodiesterase 5 inhibitor dipyridamole attenuate experimental pulmonary hypertension: Synergism upon coapplication
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Schermuly RT, Weissmann N, Enke B, et al. Urodilatin, a natriuretic peptide stimulating particulate guanylate cyclase, and the phosphodiesterase 5 inhibitor dipyridamole attenuate experimental pulmonary hypertension: synergism upon coapplication. Am J Respir Cell Mol Biol 2001; 25:219-225. A new therapeutic option is investigated in this experimental study, with promising results.
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Am J Respir Cell Mol Biol
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Hubler M, Souders JE, Shade ED, et al. Effects of vaporized perfluorocarbon on pulmonary blood flow and ventilation/perfusion distribution in a model of acute respiratory distress syndrome. Anesthesiology 2001; 95:1414-1421. Both are very interesting studies with regard to the fact that the beneficial effects of vaporized perfluorocarbons in ARDS are not completely understood until today.
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Anesthesiology
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Hubler, M.1
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Jeng MJ, Kou YR, Sheu CC, et al. Effects of partial liquid ventilation with FC-77 on acute lung injury in newborn piglets. Pediatr Pulmonol 2002; 33:12-21. A nice experimental trial confirming the results of older studies but with a different perfluorocarbon.
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Jeng, M.J.1
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