Different glial reactions to hippocampal stab wounds in young adult and aged rats

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 58, Issue 2, 2003, Pages 117-122

  Zhu, Waner ^a   Umegaki, Hiroyuki ^a   Shinkai, Tadashi ^b   Kurotani, Shinobu ^a   Suzuki, Yusuke ^a   Endo, Hidetoshi ^c   Iguchi, Akihisa ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^c CHUBU NATIONAL HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; GLIAL FIBRILLARY ACIDIC PROTEIN; MONOCYTE MACROPHAGE ANTIGEN; UNCLASSIFIED DRUG;

ADOLESCENT; AGE; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; BRAIN INJURY; CELL ACTIVATION; CELL FUNCTION; GLIA CELL; HIPPOCAMPUS; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; STAB WOUND;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0037320035     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/58.2.b117     Document Type: Article

References (26)

1. Xiao BG, Link H. Immune regulation within the central nervous system. J Neurol Sci. 1998;157:1-12.
2. Thomas WE. Brain macrophages: evaluation of microglia and their functions. Brain Res Rev. 1992;17:61-74.
3. Kreutzberg GW. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 1996;19:312-318.
4. McGeer PL, McGeer EG. The inflammatory response system of brain: implications for therapy of Alzheimer's and other neurodegenerative diseases. Brain Res Rev. 1995;21:195-218.
5. Kullberg S, Aldskogius H, Ulfhake B. Microglia activation, emergence of ED1-expressing cells and clusterin upregulation in the aging rat CNS, with special reference to the spinal cord. Brain Res. 2001;899:169-186.
6. Marty S, Dusart I, Peschanski M. Glial changes following an excitotoxic lesion in the CNS-I. Microglia/macrophages. Neuroscience. 1991;45:529-539.
7. Dijkstra CD, Dopp EA, Joling P, Kraal G. The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3. Immunology. 1985;54:589-599.
8. Damoiseaux JGMC, Dopp EA, Calame W, Chao D, Macpherson GG, Dijkstra CD. Rat macrophage lysosomal membrane antigen recognized by monoclonal antibody ED1. Immunology. 1994;83:140-147.
9. Eng LF. Glial fibrillary acidic protein (GFAP): the major protein of glial intermediate filaments in differentiated astrocytes. J Neuroimmunol. 1985;8(4-6):203-214.
10. Giulian D, Chen J, Ingeman JE, George JK, Noponen M. The role of mononuclear phagocytes in wound healing after traumatic injury to adult mammalian brain. J Neurosci. 1989;9:4416-4429.
11. McGeer PL, Kawamata T, Walker DG, Akiyama H, Tooyama I, McGeer EG. Microglia in degenerative neurological disease. Glia. 1993;7:84-92.
12. Amat JA, Ishiguro H, Nakamura K, Norton WT. Phenotypic diversity and kinetics of proliferating microglia and astrocytes following cortical stab wounds. Glia. 1996;16:368-382.
13. Fujita T, Yoshimine T, Maruno M, Hayakawa T. Cellular dynamics of macrophages and microglial cells in reaction to stab wounds in rat cerebral cortex. Acta Neurochir. 1998;140:275-279.
14. Pennings JL, Bachulis BL, Simons CT, Slazinski T. Survival after severe brain injury in the aged. Arch Surg. 1993;128:787-794.
15. Kyrkanides S, O'Banion MK, Whiteley PE, Daeschner JC, Olschowka JA. Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury. J Neuroimmunol. 2001;119:269-277.
16. Liu J, Bartels M, Lu A, Sharp FR. Microglia/macrophages proliferate in striatum and neocortex but not in hippocampus after brief global ischemia that produces ischemic tolerance in gerbil brain. J Cerebr Blood F Met. 2001;21:361-373.
17. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. 2nd ed. San Diego, CA: Academic; 1986.
18. Ogura K, Ogawa M, Yoshida M. Effects of ageing on microglia in the normal rat brain: immunohistochemical observations. Neuroreport. 1994;5:1224-1226.
19. Sheffield LG, Berman NE. Microglial expression of MHC class II increases in normal aging of nonhuman primates. Neurobiol Aging. 1998;19:47-55.
20. Hansen LA, Armstrong DM, Terry RD. An immunohistochemical quantification of fibrous astrocytes in aging human cerebral cortex. Neurobiol Aging. 1987;8:1-6.
21. Gordon MN, Schreier WA, Ou X, et al. Exaggerated astrocyte reactivity after nigrostriatal deafferentation in the aged rat. J Comp Neurol. 1997;388:106-119.
22. Wegiel J, Wisniewski HM. The complex of microglia cells and amyloid star in three-dimensional reconstruction. Acta Neuropathol. 1990;81:116-124.
23. Wisniewski HM, Wegiel J. Spatial relationships between astrocytes and classical plaque components. Neurobiol Aging. 1991;12:593-600.
24. Barger SW, Harmon AD. Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E. Nature. 1997;388:878-881.
25. Ogawa O, Umegaki H, Sumi D, et al. Inhibition of inducible nitric oxide synthase gene expression by indomethacin or ibuprofen in β-amyloid protein-stimulated J774 cells. Euro J Pharmacol. 2000;408:137-141.
26. Wegiel J, Wang KC, Tamawski M, Lach B. Microglial cells are the driving force in fibrillar plaque formation, whereas astrocytes are a leading factor in plaque degradation. Acta Neuropathol 2000;100:356-364.