Descriptive study on the efficacy and safety of artesunate suppository in combination with other antimalarials in the treatment of severe malaria in Sudan

American Journal of Tropical Medicine and Hygiene

Volumn 68, Issue 2, 2003, Pages 153-158

  Awad, M I ^a   Alkadru, A M Y ^a   Behrens, R H ^b   Baraka, O Z ^a   Eltayeb, I B ^a  

^a UNIVERSITY OF KHARTOUM   (Sudan)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTESUNATE; DOXYCYCLINE; FANSIDAR; MEFLOQUINE; ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; PYRIMETHAMINE; SESQUITERPENE; SULFADOXINE; SULFADOXINE-PYRIMETHAMINE;

ADULT; ADVERSE DRUG REACTION; AGED; ARTICLE; BONE MARROW SUPPRESSION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; DRUG USE; FATALITY; FEMALE; FEVER; FOLLOW UP; HEALTH CARE ACCESS; HUMAN; INFECTION COMPLICATION; MAJOR CLINICAL STUDY; MALARIA; MALE; MEDICAL DOCUMENTATION; RECRUDESCENCE; RURAL AREA; SUDAN; ADOLESCENT; DRUG COMBINATION; HOSPITALIZATION; MALARIA FALCIPARUM; MIDDLE AGED; PATHOLOGY; RECTAL DRUG ADMINISTRATION; TREATMENT OUTCOME;

CINCHONA PUBESCENS; PROTOZOA;

ADMINISTRATION, RECTAL; ADOLESCENT; ADULT; AGED; ANTIMALARIALS; ARTEMISININS; DOXYCYCLINE; DRUG COMBINATIONS; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MALARIA, FALCIPARUM; MALE; MEFLOQUINE; MIDDLE AGED; PYRIMETHAMINE; SESQUITERPENES; SEVERITY OF ILLNESS INDEX; SUDAN; SULFADOXINE; TREATMENT OUTCOME;

EID: 0037318389     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.2003.68.153     Document Type: Article

References (24)

1. World Health Organization, 1996. Investing in health research for development. Report of the Ad Hoc Committee on Health Research Relating to Future Intervention Options. Report No: TDR/Gen/96.1. Geneva: World Health Organization.
2. Gilles HM, 1991. Introduction. In A practical handbook in the management of severe and complicated malaria, 2nd ed. Geneva: World Health Organization. 1-4.
3. White NJ, Nosten F, Looareesuwan S, White NJ, Nosten F, Looareesuwan S, Watkins WM, Marsh K, Snow RW, Kokwaro G, Ouma J, Hien TT, Moyneux ME, Taylor TE, Newbold CI, Ruebush TK, Danis M, Greenwood BM, Anderson RM, Olliaro P, 1999. Averting a malaria disaster. Lancet 353: 1965-1967.
4. White NJ, 1994. Clinical pharmacokinetics and pharmacodynamics of artemisinin derivatives. Trans R Soc Trop Med Hyg 88: 41-43.
5. Teja-Isavadharm P, Watt G, Eamsila C, Jongsakul K, Li Q, Keeratithakul G, Teja-Isavadharm P, Watt G, Eamsila C, Jongsakul K, Li Q, Keeratithakul D, Sirisopana N, Luesutthiviboon L, Brewer TG, Kyle DE, 2001. Comparative pharmacokineties and effect kinetics of orally, administered artesunate in healthy volunteers and patients with uncomplicated falciparum malaria. Am J Trop Med Hyg 65:717-721.
6. Rowland M, Thomas N, 1995. Therapeutic regimens. In Clinical pharmacokinetics-concepts and applications, 3rd ed. Baltimore: Williams & Wilkins. 83-105.
7. Barradell LB, Fitton A, 1995. Artesunate: A review of its pharmacology and therapeutic efficacy in the treatment of malaria. Drugs 50: 714-741.
8. Hien TT, White NJ. Qinghaosu. Lancet 341: 603-608.
9. Benakis A, Paris M, Loutan L, Plessas CT, Plessas ST, 1996. Pharmacokinetic study of a new pharmaceutical form of artesunate (Plasmotrim-200 Rectocaps) administered in healthy volunteers by rectal route. Jpn J Trop Med Hyg 24: 39-45.
10. Awad MI, Eltayeb IB, Taylor RB (submitted). Pharmacokinetics of artesunate following oral and rectal administration in healthy Sudanese volunteers.
11. Looareesuwan S, Wilairatana P, Vanijanonta S, Viravan C, Andrial M, 1995. Efficacy and tolerability of a sequential artesunate suppository plus mefloquine in the treatment of severe falciparum malaria. Annu Trop Med Parasitol 89: 469-475.
12. Looareesuwan S, Wilairatana P, Andrial M, 1996. Artesunate suppository for treatment of severe falciparum malaria in Thailand. Jpn J Trop Med Hyg 24: 13-15.
13. Thwe Y, Than M, Phay S, ZawOo A, YuSoe A, 1996. Artesunate-mefloquine tablets (Plasmotrim Rectocaps, Mefloquine Lactab) in the treatment of severe malaria. Jpn J Trop Med Hyg 24: 25-32.
14. Eduardo A, Gomez L, 1996. Efficacy of artesunate suppository followed by oral mefloquine in the treatment of severe malaria in endemic areas where resistance to chloroquine exists in Ecuador. Jpn J Trop Med Hyg 24: 17-24.
15. Bhatt K, Bhatt S, Omonge E, Otekol L, Andrial M, 1996. Efficacy and tolerability of a sequential artesunate suppository-mefloquine treatment of severe review falciparum malaria. Jpn J Trop Med Hyg 24: 59-63.
16. Halpaap B, Maryse N, Paris M, Benakis A, Peter G, 1998. Plasma levels of artesunate and dihydroartemisinin in children with plasmodium falciparum malaria in Gabon after administration of 50 milligram artesunate suppositories. Am J Trop Med Hyg 58: 365-368.
17. World Health Organization Severe Malaria Task Force, 1997. Task force on artesunate suppositories for malaria treatment. TDR/UNDP/World Bank/Special Programme for Research and Training in Tropical Diseases. Geneva: World Health Organization.
18. World Health Organization Severe Malaria Task Force, 1999. Workplan of the severe malaria Task Force. TDR/UNDP/ World Bank/Special Programme for Research and Training in Tropical Diseases. Geneva: World Health Organization.
19. Bunnag D, Viravan C, Looareesuwan S, Karbwang J, Harinasuta T, 1991. Clinical trial of artesunate and artemether in multidrug resistant falciparum malaria in Thailand: a Preliminary report. Southeast Asian J Trop Med Public Health 22: 380-385.
20. White NJ, Olliaro PL, 1996. Strategies for the prevention of antimalarial drug resistance: rationale for combination chemotherapy of malaria. Parasitol Today 12: 399-401.
21. World Health Organization, 2000. Severe falciparum malaria. Trans R Soc Trop Med Hyg 94: 1-90.
22. Price RN, Nosten F, Luxemburger C, ter Kuile FO, Phaipun L, Chongsuphajaisiddhi T, White NJ, 1996. Effects of artemisinin derivatives on malaria transmissibility. Lancet 347: 11654-11658.
23. Warrell DA, Molyneux ME, Beales PF, 1990. Severe and complicated malaria. Trans R Soc Trop Med Hyg 84: 1-65.
24. Von Seidlein L, Milligan P, Pinder M, Bojang K, Anyalebechi C, Gosling R, Coleman R, Ude JI, Sadiq A, Duraisingh M, Warhurst D, Alloueche A, Targett G, McAdam K, Greenwood B, Walraven G, Olliaro P and Doherty T, 2000. Efficacy of artesunate plus pyrimethamine-sulphadoxine for uncomplicated malaria in Gambian children: a double-blind randomised, controlled trial. Lancet 355: 352-357.