Maternal hyperglycemia leads to gender-dependent deficits in learning and memory in offspring

Experimental Biology and Medicine

Volumn 228, Issue 2, 2003, Pages 152-159

  Kinney, B A ^a   Rabe, M B ^a   Jensen, R A ^b   Steger, R W ^a  

^a SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SOUTHERN ILLINOIS UNIVERSITY   (United States)

Author keywords

Diabetes; Gestational diabetes; Learning and memory; Maternal diabetes; Offspring

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; LEARNING; MATERNAL DIABETES MELLITUS; MOTOR PERFORMANCE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PREGNANCY DIABETES MELLITUS; PROGENY; PURKINJE CELL; RAT; RISK ASSESSMENT;

ANIMALIA;

EID: 0037317597     PISSN: 15353702     EISSN: None     Source Type: Journal    
DOI: 10.1177/153537020322800204     Document Type: Article

References (44)

1. Weintrob N, Karp M, Hod M. Short- and long-range complications in offspring of diabetic mothers. J Diabetes Complications 10:294-301, 1996.
2. Stehbens JA, Baker GL, Kitchell M. Outcome at ages 1, 3, and 5 years of children born to diabetic women. Am J Obstet Gynecol 127:408-413, 1977.
3. Hadden DR, Byrne E, Trotter I, Harley JMG, McClure G, McAuley RR. Physical and psychological health of children of Type I (insulin-dependent) diabetic mothers. Diabetologia 26:250-254, 1984.
4. Hod M, Levy-Shiff R, Lerman M, Schindel B, Ben-Rafael Z, Bar J. Developmental outcome of offspring of pregestational diabetic mothers. J Pediatr Endocrinol Metab 12:867-872. 1999.
5. Rizzo T, Freinkel N, Metzger BE, Hatcher R, Burns WJ, Barglow P. Correlations between antepartum maternal metabolism and newborn behavior. Am J Obstet Gynecol 163:1458-1464, 1990.
6. Rizzo T, Metzger BE, Burns WJ, Burns K. Correlations between antepartum maternal metabolism and intelligence of offspring. N Engl J Med 325:911-916, 1991.
7. Rizzo T, Metzger BE, Dooley SL, Cho NH. Early malnutrition and child neurobehavioral development: insights from the study of children of diabetic mothers. Child Dev 68:26-38, 1997.
8. Sells CJ, Robinson NM, Brown Z, Knopp RH. Long-term developmental follow-up of infants of diabetic mothers. J Pediatr 125:S9-S17, 1994.
9. Silverman BL, Rizzo TA, Cho NH, Metzger BE. Long-term effects of the intrauterine environment. Diabetes Care 21:B142-B149, 1998.
10. Silverman BL, Rizzo T, Green OC, Cho NH, Winter RJ, Ogata ES, Richards GE, Metzger BE. Long-term prospective evaluation of offspring of diabetic mothers. Diabetes 40:121-125, 1991.
11. Stenninger E, Flink R, Eriksson B, Sahlen C. Long-term neurological dysfunction and neonatal hypoglycemia after diabetic pregnancy. Arch Dis Children Fetal Neonatal Education 79:F174-F179, 1998.
12. Yamashita Y, Kawano Y, Kuriya N, Murakami Y, Yoshimatsu K, Kato H. Intellectual development of offspring of diabetic mothers. Acta Paediat 85:1192-1196, 1996.
13. Ornoy A, Ratzon N, Greenbaum C, Peretz E, Soriano D, Dulitzky M. Neurobehaviour of school age children born to diabetic mothers. Arch Dis Children Fetal Neonatal Education 79:F94-F99, 1998.
14. Yogman MW, Cole P, Als H, Lester BM. Behavior of newborns of diabetic mothers. Infant Behavior Dev 5:331-340, 1982.
15. Vohr BR. Long-term follow-up of the infant of the diabetic mother. Infant of the Diabetic Mother: Report of the 93rd Ross Conference on Pediatric Research. Columbus, OH: Ross Laboratories, 1987.
16. Pettitt DJ, Bennett PH. Long-term outcome of infants of diabetic mothers. In: Reece EA, Coustan DR, Eds. Diabetes Mellitus in Pregnancy (2nd ed). New York: Churchill Livingstone, pp379-388, 1995.
17. Schulte FJ, Michaelis R, Nolte R, Albert G, Parl U, Lasson U. Brain and behavioural maturation in newborn infants of diabetic mothers. Part I: nerve conduction and EEG patterns. Neuropadiatrie 1:24-35, 1969.
18. Schulte FJ, Lasson U, Parl U, Nolte R, Jurgens U. Brain and behavioural maturation in newborn infants of diabetic mothers. Part II: sleep cycles. Neuropadiatrie 1:36-55, 1969.
19. Cummins M, Norrish M. Follow-up of children of diabetic mothers. Arch Dis Childhood 55:259-264, 1980.
20. Metzger BE, Coustan DR. Summary and recommendations of the fourth international workshop-conference on gestational diabetes mellitus. Diabetes Care 21:B161-B167, 1989.
21. Persson B, Gentz J. Follow-up of children of insulin-dependent and gestational diabetic mothers. Acta Paediat Scand 73:349-358, 1984.
22. Naeye RL. Infants of diabetic mothers: a quantitative, morphologic study. Pediatrics 35:980-988, 1965.
23. Yamano T, Shimada M, Yoshiki F, Kawasaki H, Onaga A. Quantitative synaptic changes on purkinje cell dendritic spines of rats born from streptozotocin-induced diabetic mothers. Brain Dev 8:269-273, 1986.
24. Sena A, Ferret-Sena V. Insulin and brain development. Trends Neurosci 18:485, 1995.
25. Suzuki N, Svensson K, Eriksson UJ. High glucose concentration inhibits migration of rat cranial neural crest cells in vitro. Diabetologia 39:401-411, 1996.
26. Johansson B, Meyerson B, Eriksson UJ. Behavioral effects of an intrauterine or neonatal diabetic environment in the rat. Biol Neonate 59:226-235, 1991.
27. Steger RW, Rabe M, Bucher T. Altered sex behavior in the male offspring of diabetic rats may be secondary to alterations in fetal testosterone levels. Presented at the 81st Annual Meeting of the Endocrine Society, June 12-18, 1999.
28. Ramanathan M, Jaiswal AK, Bhattacharya SK. Hyperglycaemia in pregnancy: effects on the offspring behaviour with special reference to anxiety paradigms. Indian J Exp Biol 38:231-236, 2000.
29. Pellow S, Chopin P, File SE, Briley M. Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 14:149-167, 1985.
30. Lashley KS. Brain Mechanisms and Intelligence. New York: Hafner Publishing, 1964.
31. Olton DS. The radial arm maze as a tool in behavioral pharmacology. Physiol Behavior 40:793-797, 1987.
32. Olton DS, Samuelson RJ. Remembrance of places passed: spatial memory in rats. J Exp Psychol Animal Behavior Processes 2:97-116, 1976.
33. Diaz R, Ogren SO, Blum M, Fuxe K. Prenatal corticosterone increases spontaneous and D-amphetamine-induced locomotor activity and brain dopamine metabolism in prepubertal male and female rats. Neuroscience 66:467-473, 1995.
34. , Francis D, Diorio J, Liu D, Meaney MJ. Nongenomic transmission across generations of maternal behavior and stress responses in the rat. Science 286:1155-1158, 1999.
35. Reece EA, Hobbins JC, Mahoney MJ, Petrie RH. Medicine of the Fetus and Mother. Philadelphia: J.B. Lippincott Co., 1992.
36. Golob EK, Rishi S, Becker K, Moore C. Streptozotocin diabetes in pregnant and nonpregnant rats. Metabolism 19:1014-1019, 1970.
37. Rabe M. Maternal Diabetes and the Reproductive Function of the Offspring. Master's thesis, Southern Illinois University, Carbondale, 1992.
38. Rabe MB. Fetal Exposure to Maternal Hyperglycemia or Hypoglycemia: Effects on Locomotor Activity, Passive Avoidance Learning and Immobilization Stress Response in the Adult Rat Offspring. PhD thesis, Southern Illinois University, Carbondale. Dissertation Abstracts International 58-06, Section B: 2794, 1997.
39. Battaglia G, Cabrera TM. Potentiation of 5-HT1A receptor-mediated neuroendocrine responses in male but not female rat progeny after prenatal cocaine - Evidence for gender differences. J Pharmacol Exp Therapeutics 271:1453-1461, 1994.
40. Poltyrey T, Weinstock M. Effect of prenatal stress on opioid component of exploration in different experimental situations. Pharmacol Biochem Behavior 58:387-393, 1997.
41. Mills JL, Baker L, Goldman AS. Malformations in infants of diabetic mothers occur before the seventh gestitional week. Diabetes 28:292-293, 1979.
42. Contreras-Soro J, Forsbach G, Vazquez-Rosales J, Alvarez-Garcia C, Garcia G. Noninsulin-dependent diabetes mellitus and pregnancy in Mexico. J Gynecol Obstet 34:205-210, 1991.
43. Plagemann A, Harder T, Rake A, Melchior K, Rittel F, Rohde W, Dorner G. Hypothalamic insulin and neuropeptide Y in the offspring of gestational diabetic mother rats. NeuroReport 9:4069-4073, 1998.
44. Plagemann A, Harder T, Janert U, Rake A, Rittel F, Rohde W, Dorner G. Malformations of hypothalamic nuclei in hyperinsulinemic offspring of rats with gestational diabetes. Dev Neurosci 21:58-67, 1999.