Leptin suppresses food intake and body weight in corticosterone-replaced adrenalectomized rats

Journal of Nutrition

Volumn 133, Issue 2, 2003, Pages 504-509

  Gemmill, M E ^a   Eskay, R L ^b   Hall, N L ^a   Douglass, L W ^a   Castonguay, T W ^a  

^a UNIVERSITY OF MARYLAND   (United States)

^b NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

Adrenalectomy; Body weight; Corticosterone; Food intake; Hypothalamus; Leptin

Indexed keywords

CHOLESTEROL; CORTICOSTERONE; LEPTIN;

ADRENALECTOMY; APPETITE; BODY WEIGHT; CANNULATION; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; ENERGY EXPENDITURE; FOOD INTAKE; HORMONAL THERAPY; INSULIN BLOOD LEVEL; LATERAL BRAIN VENTRICLE; MALE; NONHUMAN; RAT; STEROID THERAPY; TIME; TREATMENT OUTCOME; WEIGHT REDUCTION;

EID: 0037317534     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/133.2.504     Document Type: Conference Paper

References (27)

1. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L. & Friedman, J. M. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature (Lond.) 372: 425-432.
2. Maffei, M., Fei, H., Lee, G.-H., Dani, C., Leroy, P., Zhang, Y., Proenca, R., Negrel, R., Ailhaud, G. & Friedman, J. M. (1995) Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations in the db locus. Proc. Natl. Acad. Sci. U. S. A. 92: 6957-6960.
3. Bado, A., Levasseur, S., Attoub, S., Kermorgant, S., Laigneau, J.-P., Bortoluzzi, M.-N., Moizo, L., Lehy, T., Guerre-Millo, M., Le Marchand-Brustel, Y. & Lewin, M. J. M. (1998) The stomach is a source of leptin. Nature (Lond.) 394: 790-793.
4. Morash, B., Li, A., Murphy, P. R., Wilkinson, M. & Ur, E. (1999) Leptin gene expression in the brain and pituitary gland. Endocrinology 140: 5995-5998.
5. Masuzaki, H., Ogawa, Y., Sagawa, N., Hosoda, K., Matsumoto, T., Mise, H., Nishimura, H., Yoshimasa, Y., Tanaka, I., Mori, T. & Nakao, K. (1997) Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat. Med. 3: 1029-1033.
6. Spinedi, E. & Gaillard, R. C. (1998) A regulatory loop between the hypothalmo-pituitary-adrenal (HPA) axis and circulating leptin: a physiological role of ACTH. Endocrinology 139: 4016-4020.
7. Cizza, G., Lotsikas, A., Licinio, J., Gold, P. & Chrousos, G. (1997) Plasma leptin levels do not change in patients with Cushing's disease shortly after correction of hypercortisolism. J. Clin. Edocrinol. Metab. 82: 2747-2750.
8. Murakami, T., Iida, M. & Shima, K. (1995) Dexamethasone regulates obese expression in isolated rat adipocytes. Biochem. Biophys. Res. Commun. 214: 1260-1267.
9. Slieker, L. J., Sloop, K. W., Surface, P. L., Kriauciunas, A., LaQuier, F., Manetta, J., Bue-Valleskey, J. & Stephens, T. W. (1996) Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP. J. Biol. Chem. 271: 5301-5304.
10. Kiess, W., Englaro, P., Hanitsch, S., Rascher, W., Attanasio, A. & Blum, W. F. (1996) High leptin concentrations in serum of very obese children are further stimulated by dexamethasone. Horm. Metab. Res. 28: 708-710.
11. Bai, H. & Castonguay, T. (2001) Effects of adrenalectomy and hormone replacement on B6C3F1 mice fed a high-fat diet. Physiol. Behav. 72: 1-6.
12. Arvaniti, K., Deshaies, Y. & Richard, D. (1998) Effect of leptin on energy balance does not require the presence of intact adrenals. Am. J. Physiol. 275: R105-R111.
13. Solomon, J. & Mayer, J. (1973) The effect of adrenalectomy on the development of the obese-hyperglycemic syndrome in OB/OB mice. Endocrinology 93: 510-513.
14. Bligh, M. E., Douglass, L. W. & Castonguay, T. W. (1993) Corticosterone modulation of dietary selection patterns. Physiol. Behav. 53: 975-982.
15. Trocki, O., Baer, D. & Castonguay, T. (1995) Comparison of effects of adrenalectomy and RU-486 in rats given a choice of maintenance diet and fat supplement. Am. J. Physiol. 269: R708-R718.
16. Yukimura, Y. & Bray, G. (1978) Effects of adrenalectomy on body weight and the size and number of fat cells in the Zucker (fatty) rat. Endocr. Res. Commun. 5: 189-198.
17. Freedman, M. R., Horwitz, B. A. & Stern, J. S. (1986) Effect of adrenalectomy and glucocorticoid replacement on development of obesity. Am. J. Physiol. 250: R595-R607.
18. Stern, J., Brown, S., Stanhope, K., Uriu, J., Castonguay, T. & Bray, G. (1983) Adrenalectomy reduces weight gain, adipose cell size and lipoprotein lipase activity in obese male Zucker rats (fa/fa). Fed. Proc. 42: 393.
19. Castonguay, T., Dallman, M. & Stern, J. (1984) Corticosterone prevents body weight loss and diminished fat appetite following adrenalectomy. Nutr. Behav. 2: 115-125.
20. Zakrzewska, K. E., Cusin, I., Sainsbury, A., Rohner-Jeanrenaud, F. & Jeanrenaud, B. (1997) Glucocorticoids as counterregulatory hormones of leptin: toward an understanding of leptin resistance. Diabetes 46: 717-719.
21. Meijer, O., E. DeLange, D. Breimer, A. DeBoer, J. Workel, and E. R. DeKloet (1998) Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice. Endocrinology 139: 1789-1793.
22. Hamelink, C. R., Currie, P. J., Chambers, J. W., Castonguay, T. W. & Coscina, D. V. (1994) Corticosterone-responsive and -unresponsive metabolic characteristics of adrenalectomixed rats. Am. J. Physiol. 267: R799-R804.
23. Naeser, P. (1973) Effects of adrenalectomy on the obese-hyperglycemic syndrome in mice (gene symbol ob). Diabetologia 9: 376-379.
24. Debons, A., Tse, C., Zurek, L., Abarahamsen, S. & Maayan, L. (1986) Adrenalectomy induced anorexia in gold thioglucose-treated obese mice: metabolic and hormonal changes. Physiol. Behav. 38: 111-117.
25. Dallman, M. F., Levin, N., Cascio, C. S., Akana, S. F., Jacobsen, L. & Kuhn, R. W. (1989) Pharmacological evidence that the inhibition of diurnal adrenocorticotropin secretion by corticosteroids is mediated via type 1 corticosterone-preferring receptors. Endocrinology 124: 2844-2850.
26. De Vos, P., Saladin, R., Auwerx, J. & Staels, B. (1995) Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J. Biol. Chem. 270: 15958-15961.
27. Gosselin, C., Campfield, L. A. & Cabanac, M. (2000) Lipostat in the lean rat: evidence for a non-causal relationship between glucocorticoids and leptin levels. Appetite 35: 57-63.