Computational and experimental analysis reveals a novel Src family kinase in the C.elegans genome

Bioinformatics

Volumn 19, Issue 2, 2003, Pages 169-172

  Pandey, Akhilesh ^a   Peri, Suraj ^a   Thacker, Colin ^b   Whipple, Cherry A ^c   Collins, John J ^c   Mann, Matthias ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF NEW HAMPSHIRE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; PROTEIN TYROSINE KINASE; TYROSINE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CAENORHABDITIS ELEGANS; CARBOXY TERMINAL SEQUENCE; COMPUTER PROGRAM; CONTROLLED STUDY; DNA ISOLATION; DROSOPHILA; ENZYME ANALYSIS; EXPERIMENTATION; FLY; GENE ACTIVITY; GENE FUNCTION; GENE IDENTIFICATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC CODE; GENETIC CONSERVATION; GENETIC REGULATION; HUMAN; MYRISTYLATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PHYLOGENY; PREDICTION; PRIORITY JOURNAL; PROTEIN FAMILY; SEQUENCE DATABASE; SPECIES DIFFERENCE; VALIDATION PROCESS; VERTEBRATE; WORM;

ANIMALIA; CAENORHABDITIS; CAENORHABDITIS ELEGANS; VERTEBRATA;

EID: 0037314080     PISSN: 13674803     EISSN: 13674811     Source Type: Journal    
DOI: 10.1093/bioinformatics/19.2.169     Document Type: Article

References (20)

1. Felsenstein,J. (1985) Confidence limits on phylogenies: an approach using the bootstrap. Evolution, 39, 783-791.
2. Galperin,M.Y. and Koonin,E.V. (1998) Sources of systematic error in functional annotation of genomes: domain rearrangement, non-orthologous gene displacement and operon disruption. In Silico Biol., 1, 55-67.
3. Hughes,A.L. (1996) Evolution of the src-related protein tyrosine kinases. J. Mol. Evol., 42, 247-256.
4. International Human Genome Sequencing Consortium (2001) Initial sequencing and analysis of the human genome. Nature, 409, 860-921.
5. Liu,X. et al. (1999) STAT Genes Found in C.elegans. Science, 285-167a.
6. Page,R.D. (1996) Tree View: an application to display phylogenetic trees on personal computers. Comput. Appl. Biosci., 12, 12357-358.
7. Pawson,R. and Scott,J.D. (1997) Signaling through scaffold, anchoring, and adaptor proteins. Science, 278, 2075-2080.
8. Plowman,G.D. et al. (1999) The protein kinases of Caenorhabditis elegans: a model for signal transduction in multicellular organisms. Proc. Natl Acad. Sci. USA, 96, 13603-13610.
9. Resh,M.D. (1994) Myristylation and palmitylation of Src family members: the fats of the matter. Cell, 76, 411-413.
10. Saitou,N. and Nei,M. (1987) The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol. Biol. Evol., 4, 406-425.
11. Schultz,J. et al. (1998) SMART, a simple modular architecture research tool: identification of signaling domains. Proc. Natl Acad. Sci. USA, 95, 5857-5864.
12. Simon,M.A. et al. (1985) The nucleotide sequence and the tissue-specific expression of Drosophila c-src. Cell, 42, 831-840.
13. Sonnhammer,E.L. et al. (1998) Pfam: multiple sequence alignments and HMM-profiles of protein domains. Nucleic Acids Res., 26, 320-322.
14. Stehelin,D. et al. (1976) DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature, 260, 170-173.
15. Superti-Furga,G. and Courtneidge,S.A. (1995) Structure-function relationships in Src family and related protein tyrosine Kinases. Bioessays, 17, 321-330.
16. Takahashi,F. et al. (1996) Regulation of cell-cell contacts in developing Drosophila eyes by Dsrc41, a new, close relative of vertebrate c-src. Genes Dev., 10, 1645-1656.
17. Tatusova,T.A. and Madden,T.L. (1996) BLAST 2 Sequences, a new tool for comparing protein and nucleotide sequences. FEMS Microbiol. Lett., 174, 247-250.
18. The C.elegans sequencing consortium (1998) Genome sequence of the nematode C.elegans: a platform for investigating biology. Science, 282, 2012-2018.
19. Thompson,J.D. et al. (1994) ClustalW: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res., 22, 4673-4680.
20. Venter,J.C. et al. (2001) The sequence of the human genome. Science, 291, 1304-1351.