Stroke damage in mice after knocking the neutrophin-4 gene into the brain-derived neurotrophic factor locus

Journal of Cerebral Blood Flow and Metabolism

Volumn 23, Issue 2, 2003, Pages 150-153

  Endres, Matthias ^a   Fan, Guoping ^b   Hirt, Lorenz ^c   Jaenisch, Rudolf ^d  

^a HUMBOLDT UNIVERSITY   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^d WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

BDNF; Cerebral ischemia; Knock in; Neurotrophins; NT4

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GROWTH FACTOR; NEUROTROPHIN 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DISEASE PREDISPOSITION; GENE EXPRESSION; GENE LOCUS; KNOCKOUT GENE; KNOCKOUT MOUSE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SEQUENCE ANALYSIS; STROKE;

EID: 0037313969     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.WCB.0000043949.67811.C6     Document Type: Article

References (20)

1. Beck T, Lindholm D, Castén E, Wree A (1994) Brain-derived neurotrophic factor protects against ischemic cell damage in rat hippocampus. J Cereb Blood Flow Metab 14:689-692
2. Bederson JB, Pitts LH, Tsuji M, Nishimuira MC, Davis RL, Bartkowski H (1986) Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17:472-476
3. Bothwell M (1995) Functional interactions of neurotrophins and neurotrophin receptors Annu Rev Neurosci 18:223-253
4. Chan KM, Lam DT, Pong K, Widmer HR, Hefti F (1996) Neurotrophin-4/5 treatment reduces infarct size in rats with middle cerebral artery occlusion. Neurochem Res 21:763-767
5. Endres M, Wang Z-Q, Namura S, Waeber C, Moskowitz MA (1997) Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase. J Cereb Blood Flow Metab 17:1143-1151
6. Endres M, Fan G, Hirt L, Fujii M, Matsoshita K, Liu X, Jaenisch R, Moskowitz MA (2000) Ischemic brain damage in mice after selectively modifying BDNF or NT4 gene expression. J Cereb Blood Flow Metab 20:139-144
7. Emfors P, Lee KF, Jaenisch R (1994) Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature 368:147-150
8. Fan G, Egles C, Sun Y, Minichello L, Renger JJ, Klein R, Liu G, Jaenisch R (2000) Knocking the NT4 gene into the BDNF locus rescues BDNF deficient mice and reveals distinct NT4 and BDNF activities. Nature Neurosci 3:350-357
9. Jones KR, Farinas I, Backus C, Reichardt LF (1994). Targeted disruption of the BDNF gene perturbs brain and sensory development but not motor neuron development. Cell 76:989-999
10. Klein R, Naduri V, Jing S, Lamballe F, Tapley P, Bryant S, Cordon-Cardo C, Jones KR, Reichardt LF, Barbacid M (1991) The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. Cell 66:395-403
11. Klein R, Lamballe F, Bryant S, Barbacid M (1992) The trkB tyrosine protein kinase is a receptor for neurotrophin-4. Neuron 8:947-956
12. Kokaia Z, Nawa H, Uchino H, Elmer E, Kokaia M, Carnahan J, Smoth ML, Siesjo BK, Lindvall O (1996) Regional brain-derived neurotrophic factor mRNA and protein levels following transient forebrain ischemia in the rat. Brain Res Mol Brain Res 38:139-144
13. Kokaia Z, Andsberg G, Martinez-Serrano A, Lindvall O (1998) Focal cerebral ischemia in rats induces expression of p75 neurotrophin receptor in resistant striatal cholinergic neurons. Neuroscience 84:1113-1125
14. Lewin GR, Barde YA (1996) Physiology of neurotrophins. Annu Rev Neurosci 19:289-317
15. Lindvall OP, Ernfors P, Bengzon J, Kokaia Z, Smith ML, Siesjo BK, Persson H (1992) Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult brain following cerebral ischemia and hypoglycemic coma. Proc Natl Acad Sci U S A 89:648-652
16. Liu X, Emfors P, Wu H, Jaenisch R (1995) Sensory but not motor neuron deficits in mice lacking NT4 and BDNF. Nature 375:238- 241
17. Merlio J-P, Emsfors P, Kokaia Z, Middlemas DS, Bengzon J, Kokaua M, Smith ML, Siesjo BK, Hunter T, Lindvall O (1993) Increased production of the TrkB protein tyrosine kinase receptor after brain insults. Neuron 10:151-164
18. Schäbitz W-R, Schwab S, Spranger M, Hacke W (1997) Intraventricular brain-derived neurotrophic factor reduces infarct size after focal cerebral ischemia in rats. J Cereb Blood Flow Metab 17:500-506
19. Takeda A, Onodera H, Sugimoto A, Kogure K, Obinata M, Shibahara S (1993) Coordinated expression of messenger RNAs for nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 in the rat hippocampus following transient forebrain ischemia. Neuroscience 55:23-31
20. Zhang WR, Kitigawa H, Hayashi T, Sasaki C, Sakai K, Warita H, Shiro Y, Suenaga H, Ohmae H, Tsuji S, Itoh T, Nishimura O, Nagasaki H, Abe K (1999) Topical application of neurotrophin-3 attenuates ischemic brain injury after transient middle cerebral artery occlusion in rats. Brain Res 762:240-2