Effect of small doses of dexamethasone on plasma leptin levels in normal and obese subjects: A dose-response study

Journal of Endocrinological Investigation

Volumn 26, Issue 2, 2003, Pages 111-116

  Putignano, P ^a   Brunani, A ^b   Dubini, A ^a   Bertolini, M ^a   Pasquali, R ^c   Cavagnini, Francesco ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Body fat distribution; Dexamethasone; Insulin sensitivity; Leptin

Indexed keywords

BIOCHEMICAL MARKER; DEXAMETHASONE; GLUCOCORTICOID; GLUCOSE; HYDROCORTISONE; INSULIN; LEPTIN;

ADIPOSE TISSUE; ADULT; AGE; ARTICLE; BODY FAT; BODY MASS; BODY WEIGHT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET RESTRICTION; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG EFFECT; FEMALE; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; HUMAN; HYDROCORTISONE BLOOD LEVEL; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OBESITY; PROTEIN BLOOD LEVEL; PROTEIN SECRETION; SEX DIFFERENCE;

EID: 0037313891     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03345137     Document Type: Article

References (42)

1. Licinio J., Mantzoros C., Negrao A.B. et al. Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. Nat. Med. 1997, 3: 575-579.
2. Korbonits M., Trainer P.J., Little J.A. et al. Leptin levels do not change acutely with food administration in normal or obese subjects, but are negatively correlated with pituitary-adrenal activity. Clin. Endocrinol. 1997, 46: 751-757.
3. Bornstein S.R., Uhlmann K., Haidan A., Ehrhart-Bornstein M., Scherbaum W.A. Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland: Leptin inhibits cortisol release directly. Diabetes 1997; 46: 1235-1238.
4. Pralong F.P., Roduit R., Waeber G. et al. Leptin inhibits directly glucocorticoid secretion by normal human and rat adrenal gland. Endocrinology 1998, 139: 4264-4268.
5. Wabitsch M., Jensen P.B., Blum W.F. et al. Insulin and cortisol promote leptin production in cultured human fat cells. Diabetes 1996, 45: 1435-1438.
6. Casabiell X., Pineiro V, Peino R. et al. Gender differences in both spontaneous and stimulated leptin secretion by human omental adipose tissue in vitro: Dexamethasone and estradiol stimulate leptin release in women, but not in men. J. Clin. Endocrinol. Metab. 1998, 83: 2149-2155.
7. Halleux C.M., Servais I., Reul B.A., Detry R., Brichard S.M. Multihormonal control of ob gene expression and leptin secretion from cultured human visceral adipose tissue: Increased responsiveness to glucocorticoids in obesity. J. Clin. Endocrinol. Metab. 1998, 83: 902-910.
8. Williams L.B., Fawcett R.L., Waechter A.S. et al. Leptin production in adipocytes from morbidly obese subjects: Stimulation by dexamethasone, inhibition by troglitazone, and influence of gender. J. Clin. Endocrinol. Metab. 2000, 85: 2678-2684.
9. Miell J.P., Englaro P., Blum W.F. Dexamethasone induces an acute and sustained rise in circulating leptin levels in normal human subjects. Horm. Metab. Res. 1996, 28: 704-707.
10. Larsson H., Ahren B. Short-term dexamethasone treatment increases plasma leptin indipendently of changes in insulin sensitivity in healthy women. J. Clin. Endocrinol. Metab. 1996, 81: 4428-4432.
11. Papaspyrou-Rao S., Schneider S.H., Petersen R.N., Fried S.K. Dexamethasone increases leptin expression in humans in vivo. J. Clin. Endocrinol. Metab. 1997, 82: 1635-1637.
12. Newcomer J.W., Selke G., Melson A.K., Gross J., Vogler G.P., Dagogo-Jack S. Dose-dependent cortisol-induced increases in plasma leptin concentration in healthy humans. Arch. Gen. Psych. 1998, 55: 995-1000.
13. Laferrere B., Fried S.K., Hough K., Campbell S.A., Thornton J., Pi-Sunyer F.X. Synergistic effects of feeding and dexamethasone on serum leptin levels. J. Clin. Endocrinol. Metab. 1998, 83: 3742-3745.
14. Kolaczynski J.W., Goldstein B.J., Considine R.V. Dexamethasone, OB gene, and leptin in humans: Effect of exogenous hyperinsulinemia. J. Clin. Endocrinol. Metab. 1997, 82: 3895-3897.
15. Liu J., Askari H., Dagogo-Jack S. Basal and stimulated plasma leptin in diabetic subjects. Obes. Res. 1999, 7: 537-544.
16. Kiess W., Englaro P., Hanitsch S., Rascher W., Attanasio A., Blum W.F. High leptin concentrations in serum of very obese children are further stimulated by dexamethasone. Horm. Metab. Res. 1996, 28: 708-710.
17. Dagogo-Jack S., Selke G., Melson A.K., Newcomer J.W. Robust leptin secretory responses to dexamethasone in obese subjects. J. Clin. Endocrinol. Metab. 1997, 82: 3230-3233.
18. Tataranni P., Pratley R., Maffei M., Ravussin E. Acute and prolonged administration of glucocorticoids (methylprednisolone) does not affect plasma leptin concentration in humans. Int. J. Obes. 1997, 21: 327-330.
19. Torpy D.J., Bornstein S.R., Cizza G., Chrousos G.P. The effects of glucocorticoids on leptin concentrations in humans may be restricted to acute pharmacological dosing. J. Clin. Endocrinol. Metab. 1998, 83: 1821-1822.
20. Janssen J.A., Huizenga N.A., Stolk R.P. et al. The acute effect of dexamethasone on plasma leptin concentrations and the relationships between fasting leptin, the IGF-I/IGF-BP system, dehydroepiandrosterone, androstenedione and testosterone in an elderly population. Clin. Endocrinol. 1998, 48: 621-626.
21. Elimam A., Knutson U., Brönnegard M., Stierna P., Albertsson-Wikland K., Marcus C. Variations in glucocorticoid levels within the physiological range affect plasma leptin levels. Eur. J. Endocrinol. 1998, 139: 615-620.
22. Lautenbacher S., Hebebrand J., Blum W.F., Fehmann H.C., Krieg J.C. Plasma leptin levels do not change in healthy humans shortly after a hydrocortisone challenge. Exp. Clin. Endocrinol. Diab. 1999, 107: 473-475.
23. Purnell J.Q., Samuels M.H. Levels of leptin during hydrocortisol infusions that mimic normal and reversed diurnal cortisol levels in subjects with adrenal insufficiency. J. Clin. Endocrinol. Metab. 1999, 83: 3125-3128.
24. Pasquali R., Ambrosi B., Armanini D. et al. Cortisol and ACTH response to oral dexamethasone in obesity and effects of sex, body fat distribution, and dexamethasone concentrations: A dose-response study. J. Clin Endocrinol. Metab. 2002, 87: 166-175.
25. Krug S.E., Laghlin J. Questionario di Valutazione C.D.Q. (IPAT Depression Scale) Organizzazioni Speciali, Firenze 1979.
26. Fava G.A. Assessing depressive symptoms across cultures. Italian validation of the CES-D self-rating scale. J. Clin. Psychol. 1983, 39: 249-252.
27. Steckler T., Holsboer F., Reul J.M. Glucocorticoids and depression. Baill. Best. Pract. Res. Clin. Endocrinol. Metab. 1999, 13: 597-614.
28. Antonijevic I.A., Murck H., Frieboes R.M. et al. Elevated nocturnal profiles of serum leptin in patients with depression. J. Psychiatr. Res. 1998, 32: 403-410.
29. Report of a WHO Consultation on Obesity. Obesity. Preventing and Managing the Global Epidemic. 1997 Geneva/WHO/NUT/NCD 98.1.
30. Matthews D.R., Hosker J.P., Rudensky A.S., Naylor B.A., Treacher B.F., Turner R.C. Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentration in man. Diabetologia 1985, 20: 412-419.
31. Haack D., Vecsei P., Licthwald K. et al. Some experience on radioimmunoassays of synthetic glucocorticoids. Allergologie 1980, 5: 259-67.
32. Slieker L.J., Sloop K.W., Surface P.. et al. Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP. J. Biol. Chem. 1996, 271: 5301-5304.
33. Saad M.F., Damani S., Gingerich R.L. et al. Sexual dimorphism in plasma leptin concentration. J. Clin. Endocrinol. Metab. 1997, 82: 579-584.
34. Minocci A., Savia G., Lucantoni R. et al. Leptin plasma concentration are dependent on body fat distribution in obese patients. Int. J. Obes. 2000, 24: 1139-1144.
35. Rebuffè-Scrive M., Bronnegard M., Nilsson A., Eldh J., Gustafsson J.A., Bjorntorp P. Steroid hormone receptors in human adipose tissues. J. Clin Endocrinol. Metab. 1990, 71: 1215-1219.
36. Lönnqvist F., Wennlund A., Arner P. Relationships between circulating leptin and peripheral fat distribution in obese subjects. Int. J. Obes. 1997, 21: 255-260.
37. Shimabukuro M., Koyama K., Chen G. et al. Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc. Natl. Acad. Sci. USA 1997, 94: 4637-4641.
38. Ungr R.H., Zhou Y.T., Orci L. Regulation of fatty acid homeostasis in cells: Novel role of leptin. Proc. Natl. Acad. Sci. USA 1999, 96: 2327-2332.
39. Holub M., Zwiauer K., Winkler C. et al. Relation of plasma leptin to lipoproteins in overweight children undergoing weight reduction. Int. J. Obes. 1999, 23: 60-66.
40. Krempler F., Breban., Oberkofler H. et al. Leptin, peroxisome proliferator-activated receptor-γ, and CCAAT/enhancer binding protein mRNA expression in adipose tissue of humans and their relation to cardiovascular risk factors. Arterioscler. Thromb. Vasc. Biol. 2000, 20: 443-449.
41. Kennedy A., Gettys T.W., Watson P. et al. The metabolic significance of leptin in humans: Gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure. J. Clin. Endocrinol. Metab. 1997, 82: 1293-1300.
42. Ebrecht M., Buske-Kirschbaum A., Hellhammer D. et al. Tissue specificity of glucocorticoid sensitivity in healthy adults. J. Clin. Endocrinol. Metab. 2000, 85: 3733-3739.