Structure-activity relationship of alkyl 9-nitrocamptothecin esters

Acta Pharmacologica Sinica

Volumn 24, Issue 2, 2003, Pages 109-119

  Cao, Zhi Song ^a   Pantazis, Panayotis ^a   Mendoza, John ^a   Early, Janet ^a   Kozielski, Anthony ^a   Harris, Nick ^a   Giovanella, Beppino ^a  

^a St Joseph's Medical Center Houston   (United States)

Author keywords

Antineoplastic agents; Camptothecin; Esters; Prodrugs; Structure activity relationship; Toxicity

Indexed keywords

9 NITROCAMPTOTHECIN 20 HEPATANOATE; 9 NITROCAMPTOTHECIN 20 VALERATE; ACID ANHYDRIDE; ESTER DERIVATIVE; HEPTANOIC ANHYDRIDE; PRODRUG; UNCLASSIFIED DRUG; VALERIC ANHYDRIDE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER REGRESSION; CELL CYCLE; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; COLON CARCINOMA; CONCENTRATION RESPONSE; CYTOTOXICITY; DRUG ACTIVITY; DRUG DOSE; DRUG STRUCTURE; DRUG TARGETING; ESTERIFICATION; FLOW CYTOMETRY; GROWTH INHIBITION; LEUKEMIA CELL; LUNG CARCINOMA; MELANOMA; OVARY CARCINOMA; PANCREAS CARCINOMA; STOMACH CARCINOMA; STRUCTURE ACTIVITY RELATION; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CAMPTOTHECIN; ESTERS; HL-60 CELLS; HUMANS; MICE; MICE, NUDE; MOLECULAR STRUCTURE; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP; U937 CELLS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0037310777     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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