Multivariate and multilocus variance components method, based on structural relationships to assess quantitative trait linkage via SEGPATH

Genetic Epidemiology

Volumn 24, Issue 2, 2003, Pages 128-138

  Province, Michael A ^a   Rice, T K ^a   Borecki, I B ^a   Gu, C ^a   Kraja, A ^a   Rao, D C ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Maximum likelihood; Path analysis; Quantitative trait linkage; Variance components

Indexed keywords

ARTICLE; DATA ANALYSIS; ENVIRONMENTAL FACTOR; GENETIC HETEROGENEITY; GENETIC LINKAGE; GENOTYPE; INTERMETHOD COMPARISON; LINKAGE ANALYSIS; LONGITUDINAL STUDY; MAXIMUM LIKELIHOOD METHOD; MODEL; MULTIVARIATE ANALYSIS; PATH ANALYSIS; PEDIGREE; PHENOTYPE; POPULATION MODEL; QUANTITATIVE TRAIT; SEGREGATION ANALYSIS; TECHNIQUE; TIME SERIES ANALYSIS; VARIANCE;

GENETICS, POPULATION; GENOTYPE; HUMANS; LIKELIHOOD FUNCTIONS; LINKAGE (GENETICS); LOD SCORE; MODELS, GENETIC; PEDIGREE; PHENOTYPE; QUANTITATIVE TRAIT, HERITABLE; SOFTWARE;

EID: 0037308607     PISSN: 07410395     EISSN: None     Source Type: Journal    
DOI: 10.1002/gepi.10208     Document Type: Article

References (23)

1. Almasy L, Blangero J. 1998. Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198-211.
2. Amos CI. 1994. Robust variance-components approach for assessing genetic linkage in pedigrees. Am J Hum Genet 54:535-43.
3. Blackwelder WC, Elston RC. 1982. Power and robustness of sibpair linkage tests and extensions to larger sibships. Commun Stat Theor Methods 11:449-84.
4. Boehnke M, Lange K. 1984. Ascertainment and goodness of fit of variance component models for pedigree data. In: Rao DC, Elston RC, Kuller LH, Feinleib M, Carter C, Havlik R, editors. Genetic epidemiology of coronary heart disease: past, present, and future. New York: Alan R. Liss. p 173-92.
5. Boerwinkle E, Chakraborty R, Sing CF. 1986. The use of measured genotype information in the analysis of quantitative phenotypes in man Am J Hum Genet 50:181-94.
6. Chagnon YC, Perusse L, Lamothe M, Chagnon M, Nadeau A, Dionne FT, Gagnon J, Chung WK, Leibel RL, Bouchard C. 1997. Suggestive linkages between markers on human 1p32-p22 and body fat and insulin levels in the Quebec Family Study. Obes Res 5:115-21.
7. Elston RC, Stewart J. 1971. A general model for the genetic analysis of pedigree data. Hum Hered 21:523-42.
8. Goldgar DW. 1990. Multipoint analysis of quantitative genetic variation. Am J Hum Genet 47:957-67.
9. Haseman JK, Elston RC. 1972. The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 2:3-19.
10. Kruglyak L, Lander ES. 1995. Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet 47:439-55.
11. Lalouel JM. 1979. GEMINI - a computer program for optimization of general nonlinear functions. University of Utah technical report no. 14, December 10, 1979. Salt Lake City: University of Utah.
12. Lathrop GM, Lalouel JM, Julier C, Ott J. 1984. Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci USA 81:3443-6.
13. MacCluer JW, Blangero J, Dyer TD, Speer MC. 1998. GAW10: simulated family data for a common oligogenic disease with quantitative risk factors. Genet Epdiemiol 14:737-42.
14. Morton NE, Rao DC, Lalouel JM. 1983. Methods in genetic epidemiology. Basel: S. Karger.
15. Province MA, Rao DC. 1995. A general purpose model and a computer program for combined segregation and path analysis (SEGPATH): automatically creating computer programs from symbolic language model specifications. Genet Epidemiol 12:203-21.
16. Province MA, Rao DC. 1988. Familial aggregation in the presence of temporal trends. Stat Med 7:185-98.
17. Province MA, Tishler P, Rao DC. 1989. Repeated measures model for the investigation of temporal trends using longitudinal family studies: application to systolic blood pressure. Genet Epidemiol 6:333-47.
18. Rao DC, Wette RW, Ewens WJ. 1988. Multifactorial analysis of family data ascertained through truncation: a comparative evaluation of two methods of statistical inference. Am J Hum Genet 42:506-15.
19. SAS Institute, Inc. 1987. SAS® guide to macro processing, version 6 edition. Cary, NC: SAS Institute, Inc. 233 p.
20. Schork NJ. 1993. Extended multipoint identity-by-descent analysis of human quantitative traits: efficiency, power, and modelling considerations. Am J Hum Genet 53:1306-19.
21. Self ST, Liang KY. 1987. Asymptotic properties of maximum likelihood estimators and likelihood ratio tests under nonstandard conditions. J Am Stat Assoc 82:605-10.
22. Todorov AA, Vogler GP, Gu C, Province MA, Li Z, Heath AC, Rao DC. 1998. Testing causal hypotheses in multivariate linkage analysis of quantitative traits: general formulation and application to sibpair data. Genet Epidemiol 15:263-78.
23. Williams JT, Blangero J. 1999. Comparison of variance components and sibpair-based apporaches in quantitative trait linkage analysis in unselected samples. Genet Epidemiol 16:113-34.