Acetylcholine reduces cyanide-induced superoxide anion generation and lipid peroxidation in rat brain homogenates

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 27, Issue 1, 2003, Pages 61-64

  Pillay, Ravi ^a   Maharaj, Deepa S ^a   Daniel, Sheril ^a   Daya, Santy ^a  

^a RHODES UNIVERSITY   (South Africa)

Author keywords

Acetylcholine; Alzheimer's disease; Lipid peroxidation; Neuroprotectant; Superoxide anion

Indexed keywords

ACETYLCHOLINE; FREE RADICAL; LIPID; NEUROTRANSMITTER; NITROBLUE TETRAZOLIUM; POTASSIUM CYANIDE; SCAVENGER; SUPEROXIDE;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; BRAIN LEVEL; CONTROLLED STUDY; DISEASE COURSE; DRUG ACTIVITY; DRUG EFFECT; LIPID PEROXIDATION; MALE; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; RAT;

ACETYLCHOLINE; ALZHEIMER DISEASE; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FREE RADICAL SCAVENGERS; LIPID PEROXIDATION; MALE; NEUROPROTECTIVE AGENTS; POTASSIUM CYANIDE; RATS; RATS, WISTAR; SUPEROXIDES;

EID: 0037307194     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-5846(02)00316-0     Document Type: Article

References (21)

1. Ardelt B.K., Borowitz J.L., Isom G.E. Brain lipid peroxidation antioxidant protectant mechanisms following acute cyanide intoxication. Toxicology. 56:1989;147-154.
2. Bartus R.T., Dean R.L., Beer B., Lippa A.S. The cholinergic hypothesis of geriatric memory dysfunction. Science. 217:1982;408-414.
3. Campbell I.C., Abdulla E.M. Strategic approaches to in vitro neurotoxicology. Chang L.W., Slikker W.J. Jr. Approaches and Methods. Neurotoxicology. 1995;495-505 Academic Press, London.
4. Coyle J.T., Puttfarcken P. Oxidative stress, glutamate and neurodegenerative disorders. Science. 262:1993;689-695.
5. Coyle J.T., Price D.L., DeLong M.R. Alzheimer's disease: a disorder of cortical cholinergic innervation. Science. 219:1983;1184-1190.
6. Davies P., Maloney A.F. Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet. 2:1976;1403.
7. Daya S. The role of melatonin as a neuroprotectant in Alzheimer's disease. Spec. Med. 31:1999;528-537.
8. Flynn B.L., Ranno A.E. Pharmacologic management of Alzheimer's disease. Ann. Pharmacol. 33:1999;188-197.
9. Goodman Y., Mattson M.P. Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury. Exp. Neurol. 128:1994;1-12.
10. Halliwell B. Reactive oxygen species and the central nervous system. J. Neurochem. 59:1992;1609-1623.
11. Iqbal K., Winblad B., Nishimura T., Takeda M. Alzheimer's disease. Wisniewski H.M. Biology, Diagnosis and Therapeutics. 1997;96-103 Wiley, Chichester, England.
12. Johnson J.D., Conroy W.G., Burris K.D., Isom G.E. Peroxidation of brain lipids following cyanide intoxication in mice. Toxicology. 46:1987;21-28.
13. Lockhart B.P., Benicourt C., Junien J.L., Privat A. Inhibitors of free radical formation fail to attenuate direct beta amyloid peptide mediated neurotoxicity in rat hippocampal cultures. J. Neurosci. Res. 39:1994;494-505.
14. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
15. McCord J.M. Oxygen derived free radicals in the postischaemic tissue injury. N. Engl. J. Med. 312:1985;159-163.
16. Nagai T., McGeer P.L., Peng J.H., McGeer E.G., Dolman C.E. Choline acetyltransferase immunohistochemistry in the brain of Alzheimer's disease patients and controls. Neurosci. Lett. 36:1983;195-199.
17. Ottino P., Duncan J.R. Effect of α-tocopherol succinate on free radical and lipid peroxidation levels in BL6 melanoma cells. Free Radic. Biol. 22:1997;1145-1151.
18. Slater E. Application of inhibitors and uncouplers for a study of oxidative phosphorylation. Methods Enzymol. 10:1967;48-57.
19. Southgate G., Daya S. Melatonin reduces quinolinic acid-induced lipid peroxidation in rat brain homogenate. Met. Brain Dis. 14:1999;165-171.
20. Whitehouse P.J., Price D.L., Clark A.W., Coyle J.T., DeLong M.R. Alzheimer disease: evidence of selective loss of cholinergic neurons in the nucleus basilis. Ann. Neurol. 10:1981;122-126.
21. Zar J.H. Biostatistical Analysis. 1974;151-466 Prentice Hall, Engelwood Cliffs, NJ.