Effects of muscarinic toxins MT2 and MT7, from green mamba venom, on m1, m3 and m5 muscarinic receptors expressed in Chinese Hamster Ovary cells

Toxicon

Volumn 41, Issue 2, 2003, Pages 207-215

  Bradley, Karen N ^a,b   Rowan, Edward G ^a   Harvey, Alan L ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Green mamba venom; Muscarinic receptors; Muscarinic toxins; Smooth muscle

Indexed keywords

CALCIUM ION; CARBACHOL; FURA 2; MUSCARINIC AGENT; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; PIRENZEPINE; RADIOLIGAND; VENOM;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; CYTOSOL; FEMALE; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; CALCIUM; CARBACHOL; CHO CELLS; CRICETINAE; CRICETULUS; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELAPID VENOMS; ELAPIDAE; FURA-2; HUMANS; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; NEUROTOXINS; RADIOLIGAND ASSAY; RECEPTORS, MUSCARINIC; REPTILIAN PROTEINS; TRANSFECTION;

CRICETINAE; CRICETULUS GRISEUS; CROCODYLUS NILOTICUS; DENDROASPIS; DENDROASPIS ANGUSTICEPS;

EID: 0037304819     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(02)00278-7     Document Type: Article

References (32)

1. Adem A., Asblom A., Johnasson G., Mbuga P.M., Karlsson E. Toxins from the venom of the green mamba Dendroaspis angusticeps that inhibit the binding of quinuclidinyl benzilate to muscarinic acetylcholine receptors. Biochim. Biophys. Acta. 968:1988;340-345.
2. Berridge M.J., Irvine R.F. Inositol phosphates and cell signalling. Nature. 341:1989;197-205.
3. Bonner T., Buckley N., Young A., Brann M. Identification of a family of muscarinic acetylcholine receptors genes. Science. 237:1987;527-532.
4. Bonner T., Young A., Brann M., Buckley N. Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes. Neuron. 1:1988;403-410.
5. Bradley K.N. Muscarinic toxins from the green mamba. Pharmacol. Ther. 85:2000;87-109.
6. Bradley K.N., Rowan E.G., Harvey A.L. Characterization of muscarinic toxins MT1, MT2, MT3 and MT7. Toxicon. 36:1998;1251.
7. Caulfield M.P. Muscarinic receptors, characterisation, coupling and function. Pharmac. Ther. 58:1993;319-379.
8. Doležal V., Lisá V., Tucek S. Differential effects of the M1-M5 muscarinic acetylcholine receptor subtypes on intracellular calcium and on the incorporation of choline into membrane lipids in genetically modified Chinese Hamster Ovary cell lines. Brain. Res. Bull. 42:1997;71-78.
9. El-Fakahany E.E., Surichamorn W., Amrhein C.L., Stenstrom S., Cioffi C.L., Richelson E., McKinney M. Pseudo non-competitive antagonism of muscarinic receptor mediated cyclic GMP formation and phosphoinositide hydrolysis by pirenzepine. J. Pharmacol. Exp. Ther. 247:1988;934-940.
10. Felder C. Muscarinic acetylcholine receptors: signal transduction through multiple effectors. FASEB J. 9:1995;619-625.
11. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260:1985;3440-3450.
12. Harvey A.L., Kornisiuk E., Jerusalinsky D. Muscarinic toxins from mamba venoms that act as selective agonists at M1 cholinoceptors. Can. J. Physiol. Pharmacol. 72:1994;376.
13. Hulme E., Birdsall N., Buckley N. Muscarinic receptor subtypes. Ann. Rev. Pharmac. Toxicol. 30:1990;633-673.
14. Jerusalinsky D., Harvey A.L. Toxins from mamba venoms: small proteins with selectivities for different subtypes of muscarinic acetylcholine receptors. Trends Pharmacol. Sci. 15:1994;424-430.
15. Jerusalinsky D., Cerveñansky C., Abó V., Kornisiuk E., Dajas F. Muscarinic cholinergic toxins from Dendroaspis angusticeps venom. J. Neurochem. 57:1991;S93.
16. Jerusalinsky D., Cerveñansky C., Walz R., Biachin M., Izquierdo I. A peptide muscarinic toxin from the Green Mamba venom shows agonist-like action in an inhibitory avoidance learning task. Eur. J. Pharmacol. 240:1993;103-105.
17. Jerusalinsky D., Raskovsky S., Kornisiuk E., Bernabeu R., Cerveñansky C. Muscarinic toxins from the venom of elapid snakes. Tipton K., Dajas F. Neurotoxins in Neurobiology. 1994;89-102 Ellis Horwood Ltd, Chichester.
18. Jerusalinsky D., Kornisiuk E., Harvey A.L. Selective agonists at M1 cholinoceptors: leads from muscarinic toxins from mamba snake venoms. Neurobiol. Ageing. 15:1994;S102.
19. Jerusalinsky D., Kornisiuk E., Bernabeu R., Izquierdo I., Cerveñansky C. Muscarinic toxins from the venom of Dendroaspis snakes with agonist-like actions. Toxicon. 33:1995;389-397.
20. Jerusalinsky D., Kornisiuk E., Cerveñansky C., Harvey A.L. Allosteric activation of M1 muscarinic cholinoceptors by MTx1, a protein from green mamba venom. Life Sci. 56:1995;1015.
21. Jersualinsky D., Kornisiuk E., Alfaro P., Quillfeld J., Ferreira A., Rial V.E., Duran R., Cervenansky C. Muscarinic toxins: novel pharmacological tools for the muscarinic cholinergic system. Toxicon. 38:2000;747-761.
22. Jolkkonen, M., 1996. PhD Thesis. University of Uppsala, Sweden.
23. Kornisiuk E., Jerusalinsky D., Cervenañsky C., Harvey A.L. Binding of muscarinic toxins MTx1and MTx2 from the venom of the green mamba (Dendroaspis angusticeps) to cloned human muscarinic cholinoceptors. Toxicon. 33:1995;11-18.
24. Kornisiuk E., Jerusalinsky D., Cerveñansky C., Harvey A.L. Corrigendum. Toxicon. 33:1995;1111.
25. Kornisiuk E., Cerveñansky C., Alfaro P., Bassarky M., Harvey A.L. Peptide muscarinic toxins with agonist activity that preferentially bind to the m1 receptor subtype. Commun. Biol. 13:1995;123-133.
26. 2+ mobilisation by some muscarinic antagonists. Biochem. Biophys. Res. Commun. 189:1992;919-924.
27. Max S.I., Liang J.-S., Potter L.T. Stable allosteric binding of m1-toxin to m1 muscarinic receptors. Mol. Pharmacol. 44:1993;1171-1175.
28. Max S.I., Liang J.-S., Potter L.T. Purification and properties of m1-toxin, a specific antagonist of m1 muscarinic receptors. J. Neurosci. 13:1993;4293-4300.
29. Max S.I., Liang J.-S., Valentine H.H., Potter L.T. Use of m1-toxin as a selective antagonist of m1 muscarinic receptors. J. Pharmacol. Exp. Ther. 267:1993;480-485.
30. Purkerson S.L., Potter L.T. Use of anti-muscarinic toxins to facilitate studies of striatal m4 muscarinic receptors. J. Pharmacol. Exp. Ther. 284:1998;707-713.
31. Thomas A.P., Delaville F. The use of fluorescent indicators for measurements of cytosolic-free calcium concentration in cell populations and single cells. McCormack J.G., Cobbold P.H. Cellular Calcium - A Practical Approach. 1991;1-53 Oxford University Press, New York.
32. 2+ with Quin2. Fleischer S., Fleischer B. Biomembranes, Part S: Transport: Membrane Isolation and Characterization. Biomembranes, Part S: Transport: Membrane Isolation and Characterization. vol. 172:1989;230-262 Academic Press, Orlando, FL.