Long term histological improvement and clearance of intrahepatic hepatitis C virus RNA following sustained response to interferon-ribavirin combination therapy in liver transplanted patients with hepatitis C virus recurrence

Gut

Volumn 52, Issue 2, 2003, Pages 283-287

  Bizollon, T ^a,b   Zoulim, F ^a,b   Trepo, C ^a,b   Ahmed, S N S ^a   Radenne, S ^a   Chevallier, M ^c   Chevallier, P ^d   Parvaz, P ^d   Guichard, S ^d   Ducerf, C ^e   Baulieux, J ^e  

^a HÔTEL DIEU   (France)

^b INSERM   (France)

^c Labaratoire Marcel Merieux   (France)

^d UNIVERSITÉ LYON 1   (France)

^e Croix Rousse ^*  (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2 INTERFERON; RECOMBINANT ALPHA2B INTERFERON; RIBAVIRIN; VIRUS RNA;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALLOGRAFT; ARTICLE; BIOCHEMISTRY; CHRONIC HEPATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FOLLOW UP; HEPATITIS C VIRUS; HISTOLOGY; HISTOPATHOLOGY; HUMAN; LIVER BIOPSY; LIVER TRANSPLANTATION; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECURRENT DISEASE; TREATMENT OUTCOME; VIROLOGY;

EID: 0037302607     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.52.2.283     Document Type: Article

References (19)

1. Ascher NL, Lake JR, Emond J, et al. Liver transplantation for hepatitis C virus related cirrhosis. Hepatology 1994;20:24-7S.
2. Ferrel LD, Wright TL, Roberts J, et al. Hepatitis C viral infection in liver transplant. Hepatology 1992;16:875-6.
3. Shah G, Demetris AJ, Gaveler JS, et al. Incidence, prevalence and clinical course of hepatitis following liver transplantation. Gastroenterology 1992;103:323-39.
4. Bizollon T, Mutimer D, Ducerf C, et al. Hepatitis C virus recurrence after liver transplantation. Gut 1999;44:575-8.
5. Feray C, Samuel D, Thiers V, et al. Reinfection of liver graft by hepatitis C virus after liver transplantation. J Clin Invest 1992;B9:1361-5.
6. Zhou S, Terrault NA, Ferrell L, et al. Severity of liver disease in liver transplantation recipients with hepatitis C virus infection: relationship to genotype end level of viremia. Hepatology 1996;24:1041-6.
7. Wright T L, Donegan E, Hsu H H, et al. Recurrent and acquired hepatitic viral infection in liver transplant recipients. Gastroenterology 1992;103:317-22.
8. Gane E J, Portmann B C, Naoumov N V, et al. Long term outcome of hepatitis C infectian after liver transplantation. N Engl J Med 1996;334:815-20.
9. Feray C, Caccamo L, Alexander GJ, et al. Eurapean collaborative study on factars influencing outcome after liver transplantatian for hepatitis C (European concerted action on viral hepatitis. Eurohep group). Gastroenterology 1999;117:619-35.
10. Schluger LK, Sheiner PA, Thung SN, et al. Severe recurrent cholestatic hepatitis C following orthotopic liver transplantation. Hepatology 1996;23:971-6.
11. Bizollon T, Palazzo U, Ducerf C, et al. Pilot study of the combination of alpha interferon and ribavirin as therapy of recurrent hepatitis C after liver transplantation. Hepatology 1997;26:500-4.
12. Samuel D, Bizollon T, Feray C, et al. Combination of interferon alpha 2bplus ribavirin for recurrent HCV infection after liver transplantation: a randomized controlled study. Hepatology 2000;32:259A.
13. Parvaz P, Guichard S, Chevallier P, et al. Hepatitis C: description of a highly sensitive method for clinical detection of viral RNA. J Virol Meth 1994;47:83-94.
14. Simmonds P. Variability of hepatitis C virus. Hepatology 1995;21:570-83.
15. Knodell RG, Ishak KG, Black WC, et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic hepatitis. Hepatology 1981;1:431-5.
16. Marcellin P, Boyer N, Gervais A, et al. Long-term histologic improvement and loss of detectable intra-hepatic HCV RNA in patients with chronic hepatitis c and sustained response to interferon-alpha therapy. Ann Int Med 1997;127:875-81.
17. Morisco F, Tucillo C, Lasevoli P, et al. Chronic hepatitis C long-term responders to human leukocyte interferon-alpha therapy: persistence of a sustained biochemical and virological response during 5 years of surveillance. Euro J Gastroenterol Hepatol 1998;10:399-403.
18. Kondo M, Tanaka K, Ikeda M, et al. Hepatic HCV-RNA as a predictor of outcome after interferon therapy in patients with chronic hepatitis C. J Gastroenterol Hepatol 1996;11:236-40.
19. Shindo M, Arai K, Sokawa Y, et al. Hepatitis C RNA as a predictor of a response to interferon-alpha therapy. Ann Intern Med 1995;122:586-91.