Antiarrhythmic effect of magnolol and honokiol during acute phase of coronary occlusion in anesthetized rats: Influence of L-NAME and aspirin

Pharmacology

Volumn 59, Issue 5, 1999, Pages 227-233

  Tsai, Shen Kou ^a,d   Huang, Cheng Hsiung ^b   Huang, Shiang Suo ^c   Hung, Li Man ^c   Hong, Chuang Ye ^b  

^a TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Aspirin; Coronary occlusion; Honokiol; L NAME; Magnolol

Indexed keywords

ACETYLSALICYLIC ACID; HONOKIOL; MAGNOLOL; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; URETHAN;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; DRUG EFFECT; HEART INFARCTION; HEART PROTECTION; HEART VENTRICLE ARRHYTHMIA; INCIDENCE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANESTHESIA; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARRHYTHMIA; ASPIRIN; BIPHENYL COMPOUNDS; BLOOD PRESSURE; CORONARY DISEASE; ENZYME INHIBITORS; LIGNANS; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0032827940     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000028324     Document Type: Article

References (14)

1. Ambrosio G, Becker LC, Hutchins GM, Weisman HF, Weisfeldt ML: Reduction in experimental infarct size by recombinant human superoxide dismutase: Insights into the pathophysiology of reperfusion injury. Circulation 1986;74:1424-1443.
2. McCord JM: Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 1985;312:159-163.
3. Baker JE, Kalyanaraman B: Ischemia-induced changes in myocardial paramagnetic metabolites: Implications for intracellular oxy-radical generation. FEBS Lett 1989;244: 311-314.
4. Lo YC, Teng CM, Chen CF, Chen CC, Hong CY: Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation. Biochem Pharmacol 1994;47:549-553.
5. Hong CY, Wang CP, Lo CY, Hsu FL: Effect of flavan-3-ol tannins purified from Camellia sinensis on lipid peroxidation of rat heart mitochondria. Am J Chin Med 1994;22: 285-292.
6. ++-channel blockade by magnolol, and antiplatelet agent isolated from Chinese herb Magnolia officinalis. Life Sci 1990;47:1153-1161.
7. Tsai SK, Huang SS, Hong CY: Myocardial protective effect of honokiol: An active component in Magnolia officinalis. Planta Med 1996;62: 503-506.
8. Hong CY, Huang SS, Tsai SK: Magnolol reduces infarct size and suppresses ventricular arrhythmia in rats subjected to coronary ligation. Clin Exp Pharmacol Physiol 1996; 23:660-664.
9. Selyes H, Bajusz E, Grasso S, Mendell P: Simple technique for the surgical occlusion of coronary vessels in the rat. Angiology 1960;11:398-407.
10. Walker MJA, Curtis MJ, Hearse DJ, Campbell RW, Janse MJ, Yellon DM, Cobbe SM, Coker SJ, Harness JB, Harron DW, Higgins AJ, Julian DG, Lab MJ, Manning AS, Northover BJ, Parratt JR, Reimersma RA, Riva E, Russell DC, Sheridan DJ, Winslow E, Woodward B: The Lambeth Conventions: Guidelines for the study of arrhythmias in ischemia, infarction and reperfusion. Cardiovasc Res 1988;22:447-455.
11. Ludbrook J: Repeated measurements and multiple comparisons in cardiovascular research. Cardiovasc Res 1994;28:303-311.
12. Teng CM, Chen CC, Ko FN, Lee LG, Huang TF, Chen YP, Hsu H: Two antiplatelet agents from Magnolia officinalis. Thromb Res 1988; 50:757-765.
13. Kanayama T, Kimura Y, Mizogami S: A new prostacyclin analog, KP-10614, inhibits platelet polymorphonuclear leucocyte interaction and limits experimental infarct size in rat heart. J Pharmacol Exp Ther 1993;266:344-349.
14. Wainwright CL, Martorana PA: Pirsidomine, a novel nitric oxide donor, suppresses ischemic arrhythmia in anesthetized pigs. J Cardiovasc Pharmacol 1993;22:S44-S50.