Structure-function relationships in the neurotoxin Vipoxin from the venom of Vipera ammodytes meridionalis

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

Volumn 59, Issue 3, 2003, Pages 617-627

  Georgieva, Dessislava Nikolova ^a   Genov, Nicolay ^a   Nikolov, Peter ^a   Aleksiev, Boris ^b   Rajashankar, Kanagalaghatta R ^c   Voelter, Wolfgang ^d   Betzel, Christian ^e  

^a INSTITUTE OF ORGANIC CHEMISTRY   (Bulgaria)

^b UNIVERSITY OF CHEMICAL TECHNOLOGY AND METALLURGY   (Bulgaria)

^c BROOKHAVEN NATIONAL LABORATORY   (United States)

^d UNIVERSITY OF TÜBINGEN   (Germany)

^e UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Phospholipase A2; Snake venom; Toxicity

Indexed keywords

BIOLOGICAL MATERIALS; CATALYSIS; DISSOCIATION; ENZYMES; FLUORESCENCE; HYDROGEN BONDS; HYDROPHILICITY; HYDROPHOBICITY; IONIZATION; MEMBRANES; MUSCLE; PROTEINS; SPECTROSCOPIC ANALYSIS; TOXICITY;

NEUROTOXINS;

TOXIC MATERIALS;

DISULFIDE; NEUROTOXIN; PHOSPHOLIPASE A; PROTEIN SUBUNIT; TRYPTOPHAN; TYROSINE; VIPER VENOM; VIPOXIN;

ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; HYDROGEN BOND; HYDROPHOBICITY; OXIDATION REDUCTION REACTION; SNAKE; SPECTROFLUOROMETRY; SPECTROPHOTOMETRY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; DISULFIDES; HYDROGEN BONDING; HYDROPHOBICITY; MODELS, MOLECULAR; NEUROTOXINS; OXIDATION-REDUCTION; PHOSPHOLIPASES A; PROTEIN SUBUNITS; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTOPHAN; TYROSINE; VIPER VENOMS; VIPERIDAE;

EID: 0037295988     PISSN: 13861425     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1386-1425(02)00212-3     Document Type: Article

References (19)

1. Mancheva I., Kleinschmidt T., Aleksiev B., Braunitzer G. Biol. Chem. Hoppe-Seyler. 368:1987;343.
2. Aleksiev B., Tchorbanov B. Toxicon. 14:1976;477.
3. Perbandt M., Wilson J.C., Eschenburg S., Mancheva I., Aleksiev B., Genov N., Willingmann P., Weber W., Singh T.P., Betzel Ch. FEBS Lett. 412:1997;573.
4. Banumathi S., Rajashankar K.R., Noetzel C., Aleksiev B., Singh T.P., Genov N., Betzel Ch. Acta Crystallogr. D57:2001;1552.
5. Chorbanov B., Aleksiev B. J. Appl. Biochem. 3:1981;558.
6. Tachibana A., Murachi T. Biochemistry. 5:1966;2756.
7. A. Roussel, C. Cambillau, Silicon graphics geometry partners directory, Silicon graphics, Mountain View, CA, 1991, p. 86.
8. S.J. Hubbard, J.M. Thornton, J. Naccess Computer Program, Department of Biochemistry and Molecular Biology, University College, London, 1993.
9. Ellman G.L. Arch. Biochem. Biophys. 82:1959;70.
10. Tchorbanov B., Aleksiev B., Bukolova-Orlova T., Burstain E., Atanasov B. FEBS Lett. 76:1977;266.
11. Genov N., Dolashka P. Bulg. Chem. Commun. 28:1995;384.
12. 2 Enzymes. 1997;245 John Wiley and Sons, Chichester.
13. 2 Enzymes. 1997;185 John Wiley and Sons, Chichester.
14. Zhou F., Schulten K. Proteins: Struct. Funct. Genet. 25:1996;12.
15. Sumandea M., Das S., Sumandea C., Cho W. Biochemistry. 38:1999;16 290.
16. Delot E., Bon C. Biochemistry. 32:1993;10 708.
17. Lomonte B., Pizarro-Cerda J., Angulo Y., Gorvel J.P., Moreno E. Biochim. Biophys. Acta. 1461:1999;19.
18. Wedemeyer W.J., Welker E., Narayan M., Scheraga H.A. Biochemistry. 39:2000;4207.
19. Lin S.H., Konishi Y., Denton M.E., Scheraga H.A. Biochemistry. 23:1984;5504.