Expression of connexin 37, 40 and 43 in rat mesenteric arterioles and resistance arteries

Histochemistry and Cell Biology

Volumn 119, Issue 2, 2003, Pages 139-148

  Gustafsson, Finn ^a   Mikkelsen, Hanne B ^a   Arensbak, Birgitte ^a   Thuneberg, Lars ^a   Neve, Søren ^b   Jensen, Lars J ^a   Holstein Rathlou, Niels Henrik ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Zealand Pharma AS   (Denmark)

Author keywords

Connexins; Endothelium; Gap junctions; Mesentery; Vascular smooth muscle; Vasoconstriction; Vasodilation

Indexed keywords

CONNEXIN 37; CONNEXIN 40; CONNEXIN 43;

ANIMAL CELL; ANIMAL TISSUE; ARTERIOLE; ARTERY CONSTRICTION; ARTERY ENDOTHELIUM; ARTICLE; CELL COMMUNICATION; CELL ULTRASTRUCTURE; CONTROLLED STUDY; GAP JUNCTION; HUMAN; HUMAN CELL; MALE; MESENTERIC ARTERY; MICROCIRCULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RESISTANCE BLOOD VESSEL; SMOOTH MUSCLE FIBER; VASODILATATION; VASOMOTOR REFLEX;

ANIMALIA;

EID: 0037295541     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00418-002-0493-0     Document Type: Article

References (32)

1. Arensbak B, Mikkelsen HB, Gustafsson F, Christensen T, Holstein-Rathlou NH (2001) Expression of connexin 37, 40, and 43 mRNA and protein in renal preglomerular arterioles. Histochem Cell Biol 115:479-487
2. Beyer EC, Paul DL, Goodenough DA (1987) Connexin43: a protein from rat heart homologous to a gap junction protein from liver. J Cell Biol 105:2621-2629
3. Christ GJ, Brink PR, Zhao W, Moss J, Gondre CM, Roy C, et al (1993) Gap junctions modulate tissue contractility and alpha 1 adrenergic agonist efficacy in isolated rat aorta. J Pharmacol Exp Ther 266:1054-1065
4. Christ GJ, Spray DC, el-Sabban M, Moore LK, Brink PR (1996) Gap junctions in vascular tissues. Evaluating the role of intercellular communication in the modulation of vasomotor ione. Circ Res 79:631-646
5. Daniel EE, Wang Y-F, Cayabyab FS (1998) Role of gap junctions in structural arrangements of interstitial cells of Cajal and canine ileal smooth muscle. Am J Physiol 274:G1125-1141
6. Emerson GG, Segal SS (2000) Electrical coupling between endothelial cells and smooth muscle cells in hamster feed arteries. Role in vasomotor control. Circ Res 87:474-479
7. Gustafsson F, Holstein-Rathlou NH (1999a) Conducted vasomotor responses in arterioles: characteristics, mechanisms and physiological significance. Acta Physiol Scand 167:11-21
8. Gustafsson F, Holstein-Rathlou NH (1999b) Angiotensin II modulates conducted vasoconstriction to norepinephrine and local electrical stimulation in rat mesenteric arterioles. Cardiovasc Res 44:176-184
9. Gustafsson F, Andreasen D, Salomonsson M, Jensen BL, Holstein-Rathlou NH (2001) Conducted vasoconstriction in rat mesenteric arterioles: role for dihydropyridine insensitive Ca2+-channels. Am J Physiol 280:H582-H590
10. Hennemann H, Suchyna T, Lichtenberg-Frate H, Jungbluth S, Dahl E, Schwarz J, et al (1992) Molecular cloning and functional expression of mouse connexin40, a second gap junction gene preferentially expressed in lung. J Cell Biol 117:1299-1310
11. Hillis GS, Duthie LA, Mlynski R, McKay NG, Mistry S, MacLeod AM, et al (1997) The expression of connexin 43 in human kidney and cultured renal cells. Nephron 75:458-463
12. Hong T, Hill CE (1998) Restricted expression of the gap junctional protein connexin 43 in the arterial system of the rat. J Anat 192:583-593
13. Huizinga JD, Liu LW, Blennerhassett MG, Thuneberg L, Molleman A (1992) Intercellular communication in smooth muscle. Experientia 48:932-941
14. Hwan SK, Beyer EC (2000) Heterogeneous localization of connexin40 in the renal vasculature. Microvasc Res 59:140-148
15. Kruger O, Plum A, Kim J, Winterhager E, Maxeiner S, Hallas G, et al (2000) Defective vascular development in connexin 45-deficient mice. Development 127:4179-4193
16. Leeson TS (1979) Rat retinal blood vessels. Can J Ophthalmol 14:21-28
17. Li X, Simard JM (2001) Connexin45 gap junction channels in rat cerebral vascular smooth muscle cells. Am J Physiol 281:H1890-H1898
18. Little TL, Beyer EC, Duling BR (1995) Connexin 43 and connexin 40 gap junctional proteins are present in arteriolar smooth muscle and endothelium in vivo. Am J Physiol 268:H729-H739
19. Mink D, Schiller A, Kriz W, Taugner R (1984) Interendothelial junctions in kidney vessels. Cell Tissue Res 236:567-576
20. Rhodin JA (1967) The ultrastructure of mammalian arterioles and precapillary sphincters. J Ultrastruct Res 18:181-223
21. Rhodin JA (1980) Architecture of the vessel wall. In: Bohr DF, Somlyo AP, Sparks HV (eds) Handbook of physiology. American Physiological Society, Bethesda, pp 1-32
22. Sandow SL, Hill CE (2000) Incidence of myoendothelial gap junctions in the proximal and distal mesenteric arteries of the rat is suggestive of a role in endothelium-derived hyperpolarizing factor-mediated responses. Circ Res 86:341-346
23. Segal SS (1994) Cell-to-cell communication coordinates blood flow control. Hypertension 23:1113-1120
24. Severs NJ, Rothery S, Dupont E, Coppen SR, Yeh HI, Ko YS, et al (2001) Immunocytochemical analysis of connexin expression in the healthy and diseased cardiovascular system. Microsc Res Tech 52:301-322
25. Simionescu M, Simionescu N, Palade GE (1975) Segmental differentiations of cell junctions in the vascular endothelium. The microvasculature. J Cell Biol 67:863-885
26. Somlyo AV (1980) Ultrastructure of vascular smooth muscle. In: Bohr DF, Somlyo AP, Sparks HV (eds) Handbook of physiology. American Physiological Society, Bethesda, pp 33-68
27. Sosa-Melgarejo JA, Berry CL, Robinson NA (1991) Effects of hypertension on the intercellular contacts between smooth muscle cells in the rat thoracic aorta. J Hypertens 9:475-480
28. Vigmond EJ, Bardakjian BL (1995) The effect of morphological interdigitation on field coupling between smooth muscle cells. IEEE Trans Biomed Eng 42:162-171
29. White TW, Paul DL (1999) Genetic diseases and gene knockouts reveal diverse connexin functions. Annu Rev Physiol 61:283-310
30. Willecke K, Heynkes R, Dahl E, Stutenkemper R, Hennemann H, Jungbluth S, et al (1991) Mouse connexin37: cloning and functional expression of a gap junction gene highly expressed in lung. J Cell Biol 114:1049-1057
31. Wit C de, Roos F, Bolz SS, Kirchhoff S, Kruger O, Willecke K, et al (2000) Impaired conduction of vasodilation along arterioles in connexin40-deficient mice. Circ Res 86:649-655
32. Yamamoto Y, Klemm MF, Edwards FR, Suzuki H (2001) Intercellular electrical communication among smooth muscle and endothelial cells in guinea-pig mesenteric arterioles. J Physiol 535:181-195