Ethanol impairs insulin-mediated glucose uptake by an indirect mechanism

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 6, 1996, Pages 2285-2290

  Avogaro, Angelo ^a,b   Valerio, Anna ^a   Miola, Marina ^a   Crepaldi, Cristina ^a   Pavan, Paola ^a   Tiengo, Antonio ^a   Del Prato, Stefano ^a  

^a UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^b Cattedra di Malattie del Ricambio   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; FATTY ACID; GLUCOSE; INSULIN; LACTIC ACID;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FATTY ACID BLOOD LEVEL; FOREARM; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TRANSPORT; HUMAN; HYPERINSULINEMIA; LACTATE BLOOD LEVEL; MALE; MUSCLE METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL;

ADULT; DEOXYGLUCOSE; DIABETES MELLITUS, TYPE 2; ETHANOL; FATTY ACIDS, NONESTERIFIED; FLUORINE RADIOISOTOPES; FLUORODEOXYGLUCOSE F18; FOREARM; GLUCOSE; HUMANS; INSULIN; LACTIC ACID; MALE; MIDDLE AGED; MUSCLES; OSMOLAR CONCENTRATION; REFERENCE VALUES; TRIGLYCERIDES;

EID: 0029890002     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.6.2285     Document Type: Article

References (30)

1. Lochner A, Wullf J, Madison LL. 1967 Ethanol-induced hypoglycemia. 1. The acute effects of ethanol on hepatic glucose output and peripheral glucose utilization in fasted dogs. Metab Clin Exp. 16:1-8.
2. Yki-Jarvinen H, Nikkila EA. 1985 Ethanol decreases glucose utilization in healthy man. J Clin Endocrinol Metab. 61:941-945.
3. Avogaro A, Duner E, Marescotti MC, et al. 1983 Metabolic effects of moderate alcohol intake with meals in insulin-dependent diabetics controlled by artificial endocrine pancreas (AEP) and in normal subjects. Metab Clin Exp. 32:463-470.
4. Avogaro A, Fontana P, Valerio A, et al. 1987 ETOH impairs insulin sensitivity in normal subjects. Diabetes Res. 5:23-27.
5. Shelmet JJ, Reichard GA, Skutches CL, Hoeldtke RD, Owen OE, Boden G. 1988 Ethanol causes acute inhibition of carbohydrate, fat, and protein oxidation and insulin resistance. J Clin Invest. 81:1137-1145.
6. Boden G, Chen X, DeSantis R, White J. 1993 Effects of ethanol on carbohydrate metabolism in the elderly. Diabetes. 42:28-34.
7. Spolarics Z, Bagby G. Pekala PH, Dobrescu C, Skrepnik N, Spitzer J. 1994 Acute alcohol administration attenuates insulin-mediated glucose use by skeletal muscle. Am J Physiol. 267:E886-E891.
8. Ben GP, Gnudi L, Maran A, et al. 1993 Effects of chronic ETOH intake on carbohydrate and lipid metabolism in type II non insulin dependent diabetic subjects. Am J Med. 90:70-76.
9. Capaldo B, Napoli R, Di Marino L, Picardi A, Riccardi G, Sacca L. 1988 Quantitation of forearm glucose and free fatty acid (FFA) disposal in normal subjects and type II diabetic patients: evidence against an essential role for FFA in the pathogenesis of insulin resistance. J Clin Endocrinol Metab. 67:893-898.
10. Capaldo B, Napoli R, Di Bonito P, Albano G, Sacca L. 1991 Dual mechanism of insulin action on human skeletal muscle: identification of an indirect component not mediated by FFA. Am J Physiol. 260:E389-E394.
11. Roach MK, Creaven PJ. 1968 A micro-method for the determination of acetaldehyde and ethanol in blood. Clin Chim Acta. 21:275-278.
12. Lloyd B, Burrin J, Smythe P, Alberti KGMM. 1978 Enzymic fluorometric continuous flow assays for blood glucose, lactate, pyruvate, alanine, glycerol, and 3-hydroxybutyrate. Clin Chem. 34:1727-1729.
13. Shimuzu S, Inque K, Tani Y, Yamada H. 1979 Enzymatic microdetermination of serum free fatty acids. Anal Biochem. 98:341-345.
14. Kuzuya H, Blix PM, Horwitz DL, Steiner DF, Rubenstein AH. 1977 Determination of free and total insulin and C-peptide in insulin treated diabetics. Diabetes. 26:22-29.
15. Rowell LB, Blackman ZR, Bruce RA. 1964 Indocyanine green clearance and estimated hepatic blood flow during mild and maximal exercise in upright man. J Clin Invest. 43:1677-1690.
16. Wahlefeld AW. 1976 Triglycerides. Determination after enzymatic hydrolysis. In: Bergmeyer HU, ed. Methods of enzymatic analysis. New York: Academic Press; 1831-1835.
17. Clore JN, Glickman PS, Helm ST, Nestler JE, Blackard WG. 1991 Evidence for dual control mechanism regulating hepatic glucose output in nondiabetic men. Diabetes. 40:1033-1040.
18. Yki-Jarvinen H, Koivisto VA, Ylikahri R, Taskinen MR. 1988 Acute effects of ethanol and acetate on glucose kinetics in normal subjects. Am J Physiol. 254:E175-E138.
19. Puhakainen I, Koivisto VA, Yki-Yarvinen H. 1991 No reduction in total hepatic glucose output by inhibition of gluconeogenesis with ethanol in NIDDM patients. Diabetes. 10:1319-1327.
20. Thiebaud D, Schutz Y, Acheson K, Jequier E, Felber JP, DeFronzo RA. 1983 Energy cost of glucose storage in human subjects during glucose-insulin infusions. Am J Physiol. 244:E216-E221.
21. Del Prato S, Bonadonna RC, Bonora E, et al. 1993 Characterization of cellular defects of insulin action in type 2 (non-insulin-dependent) diabetes mellitus. J Clin Invest. 91:484-494.
22. Nomura T, Iguchi A, Sakamoto N, Harris RA. 1983 Effects of octanoate and acetate upon hepatic glycolysis and lipogenesis. Biochim Biophys Acta. 754: 315-320.
23. Scheppach W, Wiggins HS, Halliday D, et al. 1988 Effect of gut-derived acetate on glucose turnover in man. Clin Sci. 75:363-370.
24. Jorfeldt L Juhlin-Dannfelt A. 1978 The influence of ethanol on splanchnic and skeletal muscle metabolism in man. Metab Clin Exp. 27:97-106.
25. Lomeo F, Khokher MA, Dandona P. 1988 Ethanol and its novel metabolites inhibit insulin action on adipocytes. Diabetes. 37:912-915.
26. Laposata M, Szczepiorkowski, Brown JE. 1995 Fatty acid ethyl esters: non-oxidative metabolites of ethanol. Prostaglandin Leuokotriene Essential Fatty Acids. 52:87-91.
27. Ferrannini E, Natali A, Brandi L, et al. 1993 Metabolic and thermogenic effects of lactate infusion in humans. Am J Physiol. 265:E504-E512.
28. Kreisberg RA, Owen WC, Siegal AM. 1971 Ethanol-induced hyperlactacidemia: inhibition of lactate utilization. J Clin Invest. 50:166-174.
29. Baraona E, Lieber CS. 1979 Effects of ethanol on lipid metabolism. J Lipid Res. 20:289-314.
30. Avogaro A, Beltramello P, Marin R, et al. 1995 Insulin action and glucose metabolism are improved by gemfibrozil treatment in hypertriglyceridemic patients. Atherosclerosis. 113:117-124.