Effects of septal cholinergic lesion on rat exploratory behavior in an open-field

Brazilian Journal of Medical and Biological Research

Volumn 36, Issue 2, 2003, Pages 233-238

  Lamprea, M R ^a   Cardenas, F P ^a   Silveira, R ^a   Walsh, T J ^b   Morato, S ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

Acetylcholinesterase; Cholinergic immunotoxin; Exploratory behavior; Medial septum; Open field; Saporin

Indexed keywords

ACETYLCHOLINESTERASE; IMMUNOTOXIN; SAPORIN;

ANIMAL EXPERIMENT; ANXIETY; AUTONOMIC NEUROPATHY; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DECAPITATION; ENZYME ACTIVITY; EXPLORATORY BEHAVIOR; FRONTAL CORTEX; HABITUATION; HIPPOCAMPUS; INJECTION SITE; MALE; MAZE TEST; NONHUMAN; OPEN FIELD TEST; RAT; REVIEW; SEPTUM NUCLEUS;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0037291930     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2003000200011     Document Type: Review

References (22)

1. Dutar MH, Bassant MH, Senut MC & Lamour Y (1995). The septohippocampal pathway: structure and function of a central cholinergic system. Physiological Reviews, 75: 393-427.
2. Shen J, Barnes CA, Wenk GL & McNaughton BL (1996). Differential effects of selective immunotoxic lesions of medial septal cholinergic cells on spatial working and reference memory. Behavioral Neuroscience, 110: 1181-1186.
3. McNaughton N & Gray JA (2000). Anxiolytic action on the behavioural inhibition system implies multiple types of arousal contribute to anxiety. Journal of Affective Disorders, 61: 161-176.
4. Walsh TJ & Chrobak JJ (1991). Animal models of Alzheimer's disease. Role of hippocampal cholinergic system in working memory. In: Dachowsky L & Flaherty C (Editors), Current Topics in Animal Learning, Brain, Emotion and Cognition. Lawrence Erlbaum, Hillsdale, NJ, USA, 347-379.
5. Kohler C & Srebro B (1980). Effects of lateral and medial septal lesions on exploratory behavior in the albino rat. Brain Research, 182: 423-440.
6. Myhrer T (1989). Exploratory behavior and reaction to novelty in rats: effects of medial and lateral septal lesions. Behavioral Neuroscience, 103: 1226-1233.
7. Lee EHY, Lin YP & Yin TH (1988). Effects of lateral and medial septal lesions on various activity and reactivity measures in rats. Physiology and Behavior, 42: 97-102.
8. Roth KA & Katz RJ (1979). Stress, behavioral arousal, and open-field activity - a reexamination of emotionality in the rat. Neuroscience and Biobehavioral Reviews, 3: 247-263.
9. Lee EHY, Tsai MJ & Chai CY (1986). Stress selectively influences central region activity of mice in an open-field. Physiology and Behavior, 37: 659-662.
10. Lee EHY, Tang YP & Chai CY (1987). Stress and corticotrophin releasing factor potentiate center region activity of mice in an open-field. Psychopharmacology, 93: 320-323.
11. Lamprea MR, Cardenas FP, Silveira R, Morato S & Walsh TJ (2000). Dissociation of memory and anxiety in a repeated elevated plus maze paradigm: forebrain cholinergic mechanisms. Behavioural Brain Research, 117: 97-105.
12. Wiley RG & Lappi DA (1994). Suicide Transport and Immunolesioning. RG Landes Co., Austin, TX, USA.
13. Wiley RG & Lappi DA (1992). Neural lesioning with ribosome-inactivating proteins: Suicide transport and immunolesioning. Trends in Neurosciences, 15: 285-290.
14. Walsh TJ, Herzog CD, Gandhi C, Stackman RW & Wiley RG (1996). Injection of IgG 192-saporin into the medial septum produces cholinergic hypofunction and dose-dependent working memory deficits. Brain Research, 726: 69-79.
15. Paxinos G & Watson C (1997). The Rat Brain in Stereotaxic Coordinates. 3rd edn. Academic Press, San Diego, CA, USA.
16. Augustinsson KB, Eriksson H & Faigersson Y (1978). A new approach to determining cholinesterase activities in samples of whole blood. Clinica Chimica Acta, 89: 239-252.
17. Lewis PR, Shute CCD & Silver A (1967). Confirmation from choline acetylase analysis of a massive cholinergic innervation to rat hippocampus. Journal of Physiology, 191: 215-224.
18. Mellgren SI & Srebro B (1973). Changes in acetylcholinesterase and distribution of degenerating fibers in the hippocampal region after septal lesions in the rat. Brain Research, 52: 19-36.
19. Dougherty KD, Salat D & Walsh TJ (1996). Intraseptal injections of the cholinergic immunotoxin 192-IgG saporin fails to disrupt latent inhibition in a conditioned test aversion paradigm. Brain Research, 736: 260-269.
20. Flicker C & Geyer MA (1982). Behavior during hippocampal microinfusions II: muscarinic locomotor activation. Brain Research, 257: 105-127.
21. Monmaur P, Sharif A & M'harzi M (1997). Involvement of septal muscarinic receptors in cholinergically mediated changes in rat rearing activity. Pharmacology, Biochemistry and Behavior, 58: 577-582.
22. Brudzynski SM, Wu M & Mogenson GJ (1988). Modulation of locomotor activity induced by injection of carbachol into the tegmental pedunculopontine nucleus and adjacent areas in the rat. Brain Research, 451: 119-125.