Clinical and immunomodulatory effects of Fun-boi, an herbal medicine, on collagen-induced arthritis in vivo

Clinical and Experimental Rheumatology

Volumn 21, Issue 1, 2003, Pages 57-62

  Niizawa, A ^a   Kogure, T ^a   Hai, L X ^a   Fujinaga, H ^b   Takahashi, K ^b   Shimada, Y ^a   Terasawa, K ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b TOYAMA PREFECTURAL CENTRAL HOSPITAL   (Japan)

Author keywords

Fun boi (Stephania tetrandra); Immunomodulation; Traditional herbal (Kampo) medicine

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD40 LIGAND; CD45 ANTIGEN; CD8 ANTIGEN; COLLAGEN ANTIBODY; COLLAGEN TYPE 2; HERBACEOUS AGENT; STEPHANIA TETRANDRA EXTRACT; UNCLASSIFIED DRUG; WATER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY BLOOD LEVEL; ARTICLE; BLOOD; CELLULAR IMMUNITY; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; HERBAL MEDICINE; HUMORAL IMMUNITY; IMMUNIZATION; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; LYMPH NODE; LYMPHOCYTE SUBPOPULATION; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SCORING SYSTEM; STEPHANIA; THYMUS;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, ORAL; ANIMALS; ARTHRITIS, EXPERIMENTAL; COLLAGEN TYPE II; DISEASE MODELS, ANIMAL; DRUGS, CHINESE HERBAL; LYMPH NODES; LYMPHOCYTE SUBSETS; MALE; MICE; MICE, INBRED DBA; PHYTOTHERAPY; PLANT ROOTS; PLANTS, MEDICINAL; SEVERITY OF ILLNESS INDEX; STEPHANIA TETRANDRA; TREATMENT OUTCOME;

EID: 0037287833     PISSN: 0392856X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. CHANG DM, CHANG WY, KUO SY, CHANG ML: The effects of traditional antirheumatic herbal medicines on immune response cells. J Rheumatol 1997; 24: 436-41.
2. HO LJ, CHANG DM, LEE TC, CHANG ML, LAI JH: Plant alkaloid tetrandrine downregulates protein kinase C-dependent signaling pathway in T cells. Eur J Pharmacol 1999; 367: 389-98.
3. TAKAHASHI K, KOBAYASHI H, KOBAYASHI S, KIMURA I, TERASAWA K, KIMURA M: Antiproliferative effects of magnosalin derived from Shin'i (Flos Magnoliae), a Japanese Sino-medicine, on cultured synovial cells of MRL/1 and C57BL/6J nice. Phytother Res 1996; 10: 42-8.
4. NIIZAWA A, KOGURE T, FUJINAGA H, TAKAHASHI K, SHIMADA Y, TERASAWA K: Clinical and immunomodulatory effect of Fun-boi, an herbal medicine, in rheumatoid arthritis. J Clin Rheumatol 2000; 6: 244-9.
5. DURIE FH, FAVA RA, NOELLE RJ: Collagen-induced arthritis as a model of rheumatoid arthritis. Clin Immunol Immunopathol 1994; 73: 11-8.
6. HOLMDAHL R, JANSSON L, ANDERSSON M: Female sex hormones suppress development of collagen-induced arthritis in mice. Arthritis Rheum 1986; 29: 1501-9.
7. TRENTHAM DE, TOWNES AS, KANG AH, DAVID JR: Humoral and cellular sensitivity to collagen in type II collagen-induced arthritis in rats. J Clin Invest 1978; 61: 89-96.
8. DATTA SK, KALLED SL: CD40-CD40 ligand interaction in autoimmune disease. Arthritis Rheum 1997; 40: 1735-45.
9. MAURI C, MARS LT, LONDEI M: Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process. Nat Med 2000; 6: 673-9.
10. DURIE FH, FAVA RA, FOY TM, ARUFFO A, LEDBETTER JA, NOELLE RJ: Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40. Science 1993; 261: 1328-30.
11. MATSUNO H, MATSUSHITA I, OKADA C, et al.: Role of lymphocytes in collagen induced arthritis. J Rheumatol 1991; 18: 1344-9.
12. FENER P, BENE MC, CHEVRIER D, et al.: Lymphocyte subpopulations in an experimental model of axial and peripheral enthesiopathies. Clin Exp Rheumatol 1992; 10: 577-81.