Synthesis of 2-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)benzimidazoles

Journal of Heterocyclic Chemistry

Volumn 40, Issue 1, 2003, Pages 37-44

  Jung, Myung Hee ^a   Park, Jung Mee ^a   Lee, Ihl Young Choi ^a   Ahn, Mija ^a  

^a Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 2 (1 METHYL 1,2,5,6 TETRAHYDROPYRIDIN 3 YL) 1H BENZIMIDAZOLE; 1,2 PHENYLENEDIAMINE; 2 (1 METHYL 1,2,5,6 TETRAHYDROPYRIDIN 3 YL) 1H BENZIMIDAZOLE; 2 (1 METHYL 1,2,5,6 TETRAHYDROPYRIDIN 3 YL)BENZIMIDAZOLE; 3 PIPERIDEINE DERIVATIVE; 5 CHLORO 1 METHYL 2 (1 METHYL 1,2,5,6 TETRAHYDROPYRIDIN 3 YL) 1H BENZIMIDAZOLE; 5 CHLORO 2 (1 METHYL 1,2,5,6 TETRAHYDROPYRIDIN 3 YL) 1H BENZIMIDAZOLE; 5 METHOXY 1 METHYL 2 (1 METHYL 1,2,5,6 TETRAHYDROPYRIDIN 3 YL) 1H BENZIMIDAZOLE; 5 METHOXY 2 (1 METHYL 1,2,5,6 TETRAHYDROPYRIDIN 3 YL) 1H BENZIMIDAZOLE; 5 NITRO 1 METHYL 2 (1 METHYL 1,2,5,6 TETRAHYDROPYRIDIN 3 YL) 1H BENZIMIDAZOLE; 5 NITRO 2 (1 METHYL 1,2,5,6 TETRAHYDROPYRIDIN 3 YL) 1H BENZIMIDAZOLE; 6 CHLORO 1 METHYL 2 (1 METHYL 1,2,5,6 TETRAHYDROPYRIDIN 3 YL) 1H BENZIMIDAZOLE; 6 METHOXY 1 METHYL 2 (1 METHYL 1,2,5,6 TETRAHYDROPYRIDIN 3 YL) 1H BENZIMIDAZOLE; 6 NITRO 1 METHYL 2 (1 METHYL 1,2,5,6 TETRAHYDROPYRIDIN 3 YL) 1H BENZIMIDAZOLE; BENZIMIDAZOLE DERIVATIVE; IODOBENZENE; METHYL IODIDE; MUSCARINIC M1 RECEPTOR AGONIST; NICOTINALDEHYDE; POTASSIUM HYDROXIDE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CYCLIZATION; DRUG SYNTHESIS; METHYLATION; OXIDATION; PROTON NUCLEAR MAGNETIC RESONANCE; REDUCTION; X RAY CRYSTALLOGRAPHY;

EID: 0037285634     PISSN: 0022152X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jhet.5570400104     Document Type: Article

References (13)

1. [a] R. Xu, M.-K. Sim and M.-L. Go, J. Med. Chem., 41, 3220 (1998);
2. [b] J. R. Prous, Cognition-enhancing drugs. In: The Year's Drug News-Therapeutic Targets, 1995 Edition, Prous Science Publishers, Barcelona, 91-113 (1995).
3. R. M. Moltzen, R. E. Pederson, K. P. Bogeso, E. Meier, K. Frederiksen, C. Sanchez and H. L. Lembol, J. Med. Chem., 37, 4085 (1994).
4. E. Toja, C. Bonetti and A. Butti, Eur. J. Med. Chem., 27, 519(1992).
5. [a] J. E. Christie, A. Shering, J. Ferguson and A. I. Glen, Br. J. Psychiatry, 138, 46 (1981);
6. [b] J. M. Palacios and R. Spiegel, Prog. Brain Res., 70, 485 (1986).
7. L. Jeppesen, P. H. Olesen, L. Hansen, M. J. Sheardown, C. Thomsen, T. Rasmussen, A. F. Jensen, M. S. Christensen, K. Rimvall, J. S. Ward, C. Whitesitt, D. O. Calligaro, F. P. Bymaster, N. W. Delapp, C. C. Felder, H. E. Shannon and P. Sauerberg, J. Med. Chem., 42, 1999 (1999).
8. [a] M. H. Jung, J.-G. Park, B.-S. Ryu and K.-W. Cho, J. Heterocyclic Chem., 36, 429 (1999);
9. [b] M. H. Jung, J.-G. Park, K.-W. Cho and H.-G. Cheon, Korean J. Med. Chem., 9, 8 (1999).
10. M. H. Jung, S.-W. Choi and K.-W. Cho, J. Heterocyclic Chem., 37, 969 (2000).
11. J. J. Baldwin, P. K. Lumma, F. C. Novello, G. S. Ponticello and J. M. Sprague, J. Med. Chem., 20, 1189 (1977).
12. L. J. Mathias and C. G. Overberger, J. Org. Chem., 43, 3526 (1978).
13. Y. Kikugawa, Synthesis, 124 (1981).