Cardiovascular reflex responses after intrathecal ω-conotoxins or dexmedetomidine in the rabbit

Clinical and Experimental Pharmacology and Physiology

Volumn 30, Issue 1-2, 2003, Pages 82-87

  Blake, Duncan W ^a   Wright, Christine E ^a   Scott, David A ^a   Angus, James A ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

2 adrenoceptors; conotoxins; Arterial baroreflex; Haemorrhage

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; DEXMEDETOMIDINE; OMEGA CONOTOXIN; OMEGA CONOTOXIN CVID; OMEGA CONOTOXIN MVIIA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; BRADYCARDIA; CARDIOTOXICITY; CARDIOVASCULAR REFLEX; CONTROLLED STUDY; FEMALE; HEART INDEX; HEART RATE; HYPOVOLEMIA; MEAN ARTERIAL PRESSURE; NONHUMAN; RABBIT; VASOCONSTRICTION;

ANIMALS; BAROREFLEX; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; DEXMEDETOMIDINE; FEMALE; HEART RATE; HEMORRHAGE; INJECTIONS, SPINAL; OMEGA-CONOTOXINS; RABBITS; VASOCONSTRICTION;

EID: 0037280492     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1681.2003.03795.x     Document Type: Article

References (24)

1. Atanassoff PG, Hartmannsgruber MW, Thrasher J et al. Ziconotide, a new N-type calcium channel blocker, administered intrathecally for acute postoperative pain. Reg. Anesth. Pain Med. 2000; 25: 274-8.
2. Khan ZP, Ferguson CN, Jones RM. Alpha-2 and imidazoline receptor agonists. Their pharmacology and therapeutic role. Anaesthesia 1999; 54: 146-65.
3. Malmberg AB, Hedley LR, Jasper JR, Hunter JC, Basbaum AI. Contribution of alpha (2) receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidine. Br. J. Pharmacol. 2001; 132: 1827-36.
4. Wang YX, Pettus M, Gao D, Phillips C, Bowersox S. Effects of intrathecal administration of ziconotide, a selective neuronal N-type calcium channel blocker, on mechanical allodynia and heat hyperalgesia in a rat model of postoperative pain. Pain 2000; 84: 151-8.
5. Buerkle H, Yaksh TL. Pharmacological evidence for different alpha 2-adrenergic receptor sites mediating analgesia and sedation in the rat. Br. J. Anaesth. 1998; 81: 208-15.
6. + channels of dorsal root ganglion neurons in a neuropathic pain model. Brain Res. 1999; 832: 195-206.
7. Wright CE, Robertson AD, Whorlow SL, Angus JA. Cardiovascular and autonomic effects of omega-conotoxins MVIIA and CVID in conscious rabbits and isolated tissue assays. Br. J. Pharmacol. 2000; 131: 1325-36.
8. ++ channel antagonist omega-conotoxin GVIA in conscious rabbits. J. Cardiovasc. Pharmacol. 1997; 30: 392-9.
9. Blake DW, Ludbrook J, Van Leeuwen AF. Dexmedetomidine and haemodynamic responses to acute central hypovolaemia in conscious rabbits. Clin. Exp. Pharmacol. Physiol. 2000; 27: 801-9.
10. Brose WG, Gutlove DP, Luther RR, Bowersox SS, McGuire D. Use of intrathecal SNX-111, a novel, N-type, voltage-sensitive, calcium channel blocker, in the management of intractable brachial plexus avulsion pain. Clin. J. Pain 1997; 13: 256-9.
11. Lewis RJ, Nielsen KJ, Craik DJ et al. Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes. J. Biol. Chem. 2000; 275: 35335-44.
12. Ludbrook J, Potocnik SJ, Woods RL. Simulation of acute haemorrhage in unanaesthetized rabbits. Clin. Exp. Pharmacol. Physiol. 1988; 15: 575-84.
13. Scott DA, Wright CE, Angus JA. Actions of intrathecal ω-conotoxins CVID, GVIA, MVIIA, and morphine in acute and neuropathic pain in the rat. Eur. J. Pharmacol. 2002 (in press).
14. Ludbrook J. Repeated measurements and multiple comparisons in cardiovascular research. Cardiovasc. Res. 1994; 28: 303-11.
15. Taittonen MT, Kirvela OA, Aantaa R, Kanto JH. Effect of clonidine and dexmedetomidine premedication on perioperative oxygen consumption and haemodynamic state. Br. J. Anaesth. 1997; 78: 400-6.
16. Devcic A, Schmeling WT, Kampine JP, Warltier DC. Oral dexmedetomidine preserves baroreceptor function and decreases anesthetic requirements of halothane-anesthetized dogs. Anesthesiology 1994; 81: 419-30.
17. Oku S, Benson KT, Hirakawa M, Goto H. Renal sympathetic nerve activity after dexmedetomidine in nerve-intact and baroreceptor-denervated rabbits. Anesth. Analg. 1996; 83: 477-81.
18. Bowersox SS, Gadbois T, Singh T, Pettus M, Wang YX, Luther RR. Selective N-type neuronal voltage-sensitive calcium channel blocker, SNX-111, produces spinal antinociception in rat models of acute, persistent and neuropathic pain. J. Pharmacol. Exp. Ther. 1996; 279: 1243-9.
19. Hawkes AL, Angus JA, Wright CE. Omega-conotoxin GVIA and prazosin, but not felodipine, cause postural hypotension in rabbits. Clin. Exp. Pharmacol. Physiol. 1995; 22: 711-16.
20. ++ channel blockade is amplified in experimental hypertension. J. Hypertens. 2000; 18: 65-73.
21. Whorlow SL, Angus JA, Wright CE. The effects of central administration of omega-conotoxin GVIA on cardiovascular parameters and autonomic reflexes in conscious rabbits. Clin. Exp. Pharmacol. Physiol. 1994; 21: 865-73.
22. Kinsella SM, Tuckey JP. Perioperative bradycardia and asystole: Relationship to vasovagal syncope and the Bezold-Jarisch reflex. Br. J. Anaesth. 2001; 86: 859-68.
23. Van Leeuwen AF, Evans RG, Ludbrook J. Haemodynamic responses to acute blood loss. New roles for the heart, brain and endogenous opioids. Anaesth. Intens. Care 1989; 17: 312-19.
24. Schadt JC, Ludbrook J. Hemodynamic and neurohumoral responses to acute hypovolemia in conscious mammals. Am. J. Physiol. 1991; 260: H305-18.