Interleukin 1β-induced inhibition of gastric acid secretion involves glutamate, NO and cGMP synthesis in the brain

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 367, Issue 1, 2003, Pages 22-27

  García Zaragozá, Eugenia ^a   Hernández, Carlos ^a   Barrachina, M Dolores ^a   Esplugues, Juan V ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Brain gut axis; Central nervous system; Endotoxin; Gastric acid secretion; Glutamate; Interleukin 1 ; Nitric oxide; Soluble guanylyl cyclase

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; CYCLIC GMP; DIZOCILPINE MALEATE; ESCHERICHIA COLI ENDOTOXIN; GLUTAMIC ACID; GUANYLATE CYCLASE INHIBITOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PENTAGASTRIN; RECOMBINANT INTERLEUKIN 1BETA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CONTROLLED STUDY; DRUG EFFECT; INHIBITION KINETICS; MALE; NONHUMAN; RAT; STOMACH ACID SECRETION;

ANIMALS; BRAIN; CYCLIC GMP; GASTRIC ACID; GLUTAMIC ACID; HUMANS; INTERLEUKIN-1; MALE; NITRIC OXIDE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0037280013     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-002-0654-7     Document Type: Article

References (34)

1. Arend WP, Welgus HG, Thompson RC, Eisenberg SP (1990) Biological properties of recombinant human monocyte-derived interleukin 1 receptor antagonist. J Clin Invest 85:1694-1697
2. Beales I (1998) H. Pylori-associated hypochlorhydria. Gastroenterology 114:618-620
3. Bredt DS, Snyder SH (1989) Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc Natl Acad Sci USA 86:9030-9033
4. 2 into the central nervous system from the blood. Br J Pharmacol 66:565-572
5. Dinarello CA (1991) Interleukin-1 and Interleukin-1 antagonism. Blood 77:1627-1652
6. El Omar EM (2001) The importance of interleukin 1β in Helicobacter pylori associated disease. Gut 48:743-747
7. Eriksson C, Nobel S, Winblad B, Schultzberg M (2000) Expression of interleukin 1 alpha and beta, and interleukin 1 receptor antagonist mRNA in the rat central nervous system after peripheral administration of lipopolysaccharides. Cytokine 12:423-431
8. Esplugues JV, Barrachina MD, Calatayud S, Pique JM, Whittle BJR (1993) Nitric oxide mediates the inhibition by interleukin-1β of pentagastrin-stimulated rat gastric acid secretion. Br J Pharmacol 108:9-10
9. Esplugues JV, Martínez-Cuesta MA, Barrachina MD, Calatayud S, Whittle BJR (1994) Involvement of endogenous nitric oxide in the inhibition by endotoxin and interleukin-1β of gastric acid secretion. J Gastroenterol Hepatol 9:S45-S49
10. Esplugues JV, Barrachina MD, Beltrán B, Calatayud S, Whittle BJR, Moncada S (1996) Inhibition of gastric acid secretion by stress: a protective reflex mediated by cerebral nitric oxide. Proc Natl Acad Sci USA 93:14839-14844
11. García-Zaragozá E, Barrachina MD, Moreno L, Esplugues JV (2000) Role of central glutamate receptors, nitric oxide and soluble guanylyl cyclase in the inhibition by endotoxin of rat gastric acid secretion. Br J Pharmacol 130:1283-1288
12. Konsman JP, Kelley K, Dantzer R (1999) Temporal and spatial relationships between lipopolysaccharide-induced expression of fos, interleukin-1beta and inducible nitric oxide synthase in rat brain. Neuroscience 89:535-548
13. Konturek PC, Brzozowski T, Konturek SJ, Stachura J, Karczewska, Pajdo R, Ghiara P, Hahn EG (1999) Mouse model of Helicobacter pylori infection: studies of gastric function and ulcer healing. Aliment Pharmacol Ther 13:333-346
14. Lieberman AP, Pitha PM, Shin HS, Shin ML (1989) Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus. Proc Natl Acad Sci USA 86:6348-6352
15. Mascarucci P, Perego C, Terrazzino S, De Simoni MG (1998) Glutamate release in the nucleus of the tractus solitarius is induced by peripheral lipopolysaccharide and interleukin-1 beta. Neuroscience 86:1285-1290
16. Oberholzer A, Oberholzer C, Moldawer LL (2000) Cytokine signalling-regulation in the immune response in normal and critically ill states. Crit Care Med 28:N3-N12
17. Opp MR, Postlethwaite AE, Seyer JM, Krueger JM (1992) Interleukin 1 receptor antagonist blocks somnogenic and pyrogenic responses to an interleukin 1 fragment. Proc Natl Acad Sci USA 89:3726-3730
18. Quan N, Stern EL, Whiteside MB, Herkenham M (1999) Induction of pro-inflamatory cytokine mRNAs in the brain after peripheral injection of subseptic doses of lipopolysaccharide in the rat. J Neuroimmunol 93:72-80
19. Robert A, Olafsson AS, Lancaster C, Zhang WR (1991) Interleukin-1 is cytoprotective, antisecretory, stimulates PGE2 synthesis by the stomach, and retards gastric emptying. Life Sci 48:123-134
20. 32P-labeled bacterial lipopolysaccharide in laboratory animals. Lancet i:366-367
21. Saperas E, Taché Y (1993) Central interleukin-1β-induced inhibition of acid secretion in rats: specificity of action. Life Sci 52:785-792
22. Saperas E, Taché Y (1994) Interleukin-1 receptor antagonist does not prevent endotoxin-induced inhibition of gastric acid secretion in rats. Dig Dis Sci 39:152-156
23. Saperas E, Yang H, Rivier C, Taché Y (1990) Central action of recombinant interleukin-1 to inhibit acid secretion in rats. Gastroenterology 99:1599-1606
24. Saperas E, Cominelli F, Taché Y (1992) Potent inhibition of gastric acid secretion by intravenous interleukin-1β and -1α in rats. Peptides 13:221-226
25. Satta MA, Jacobs RA, Kaltsas GA, Grossman AB (1998) Endotoxin induces interleukin-1β and nitric oxide synthase mRNA in rat hypothalamus and pituitary. Neuroendocrinology 67:109-116
26. Streit WJ, Semple-Rowland SL, Hurley SD, Miller RC, Popovich PG, Stokes BT (1998) Cytokine mRNA profiles in contused spinal cord and axotomized facial nucleus suggest a beneficial role for inflammation and gliosis. Exp Neurol 152:74-87
27. Suto G, Kiraly A, Taché Y (1994) Interleukin 1 beta inhibits gastric emptying in rats: mediation through prostaglandins and corticotropin-releasing factor. Gastroenterology 106:1568-1575
28. Taché Y, Saperas E (1993) Central actions of interleukin 1 on gastrointestinal function. Methods Neurosci 17:169-184
29. Turrin NP, Gayle D, Ilyn SE, Flynn MC, Langhans W, Schwartz GJ, Plata-Salaman CR (2001) Pro-inflammatory and anti-inflammatory cytokine mRNA induction in the periphery and brain following intraperitoneal administration of bacterial lipopolysaccharide. Brain Res Bull 54:443-453
30. Uehara A, Okumura T, Sekiya C, Okamura K, Takasugi Y, Namiki M (1989) Interleukin-1 inhibits the secretion of gastric acid in rats: possible involvement of prostaglandin. Biochem Biophys Res Commun 162:1578-1584
31. Uehara A, Okumura T, Kitamori S, Takasugi Y, Namiki M (1990) Interleukin-1: a cytokine that has potent antisecretory and anti-ulcer actions via the central nervous system. Biochem Biophys Res Commun 173:585-590
32. Ulich TR, Guo K, Irwin B, Remick DG, Navatelis GN (1990) Endotoxin-induced cytokine gene expression in vivo. Am J Pathol 137:1173-1185
33. Wallace JL, Cucala M, Mugridge KG, Parente L (1991) Secretagogue-specific effects of interleukin 1 on gastric acid secretion. Am J Physiol 261:G559-G564
34. Wallace JH, Keenan CM, Cucala M, Mugridge KG, Parente L (1992) Mechanisms underlying the protective effects of interlelukin 1 in experimental nonsteroideal anti-inflammatory drug gastropathy. Gastroenterology 102:1176-1185